FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022648745> ?p ?o ?g. }

• W2022648745 endingPage "11" @default.
• W2022648745 startingPage "1" @default.
• W2022648745 abstract "A skin lipid model to study barrier properties of stratum corneum has been developed. Research that led to the evolution of this model is presented along with highlights of recent findings. At normal water content of skin, the model lipid exists as a liquid crystal with only a small amount of solid crystals present. As the water content is reduced, for example by exposure to a low humidity environment, more of the solid crystal phase is found. Further X-ray diffraction studies identified the location of specific lipids in the model layered structure. Triglycerides and squalene are found in the hydrophobic methyl layer, while fatty acids, cholesterol and ceramides are located between the fatty acid chains. Water uptake was significantly enhanced when extracted stratum corneum lipids or model lipids were combined with the delipidated corneocytes, compared with water uptake of the lipids or delipidated corneocytes alone. Water uptake of the combined system was similar to that of isolated, intact stratum corneum. We determined the effect of glycerol, a well known skin moisturizer, on the model. While glycerol did not alter the water loss of the model at low relative humidity (6% RH), it maintained the liquid crystalline state of the lipid at the extreme condition; in the absence of glycerol the model showed substantial crystallization and exhibited multiple phases at 6% RH. Glycerol did not exhibit humectant behavior under these conditions. This study suggests that an alternate mechanism for moisturization may be to maintain the liquid crystalline structure under dry environmental conditions. Future studies using the model will examine the role of specific lipids and proteins in enhancing barrier properties; parameters measured will be phase behavior, water uptake/loss and alterations in diffraction patterns under different environmental conditions. Additives will be sought that improve the moisturization capacity of skin by altering biophysical properties of the lipid." @default.
• W2022648745 created "2016-06-24" @default.
• W2022648745 creator A5000330812 @default.
• W2022648745 creator A5023968347 @default.
• W2022648745 creator A5024956660 @default.
• W2022648745 creator A5036502892 @default.
• W2022648745 creator A5080173512 @default.
• W2022648745 date "1990-01-01" @default.
• W2022648745 modified "2023-09-27" @default.
• W2022648745 title "Development of a stratum corneum lipid model to study the cutaneous moisture barrier properties" @default.
• W2022648745 cites W1970078769 @default.
• W2022648745 cites W1975986537 @default.
• W2022648745 cites W1987203691 @default.
• W2022648745 cites W1990602116 @default.
• W2022648745 cites W1993709743 @default.
• W2022648745 cites W2020573304 @default.
• W2022648745 cites W2029019094 @default.
• W2022648745 cites W2034010541 @default.
• W2022648745 cites W2035866618 @default.
• W2022648745 cites W2063914080 @default.
• W2022648745 cites W2073366895 @default.
• W2022648745 cites W2081005686 @default.
• W2022648745 cites W2081294927 @default.
• W2022648745 cites W2093465273 @default.
• W2022648745 cites W2117193543 @default.
• W2022648745 cites W2303771534 @default.
• W2022648745 cites W4319053781 @default.
• W2022648745 doi "https://doi.org/10.1016/0166-6622(90)80212-m" @default.
• W2022648745 hasPublicationYear "1990" @default.
• W2022648745 type Work @default.
• W2022648745 sameAs 2022648745 @default.
• W2022648745 citedByCount "6" @default.
• W2022648745 countsByYear W20226487452013 @default.
• W2022648745 countsByYear W20226487452023 @default.
• W2022648745 crossrefType "journal-article" @default.
• W2022648745 hasAuthorship W2022648745A5000330812 @default.
• W2022648745 hasAuthorship W2022648745A5023968347 @default.
• W2022648745 hasAuthorship W2022648745A5024956660 @default.
• W2022648745 hasAuthorship W2022648745A5036502892 @default.
• W2022648745 hasAuthorship W2022648745A5080173512 @default.
• W2022648745 hasConcept C121332964 @default.
• W2022648745 hasConcept C12554922 @default.
• W2022648745 hasConcept C142724271 @default.
• W2022648745 hasConcept C158960510 @default.
• W2022648745 hasConcept C179927520 @default.
• W2022648745 hasConcept C185592680 @default.
• W2022648745 hasConcept C201268389 @default.
• W2022648745 hasConcept C2776703722 @default.
• W2022648745 hasConcept C2778370115 @default.
• W2022648745 hasConcept C2780881558 @default.
• W2022648745 hasConcept C43617362 @default.
• W2022648745 hasConcept C55493867 @default.
• W2022648745 hasConcept C71924100 @default.
• W2022648745 hasConcept C86803240 @default.
• W2022648745 hasConcept C97355855 @default.
• W2022648745 hasConceptScore W2022648745C121332964 @default.
• W2022648745 hasConceptScore W2022648745C12554922 @default.
• W2022648745 hasConceptScore W2022648745C142724271 @default.
• W2022648745 hasConceptScore W2022648745C158960510 @default.
• W2022648745 hasConceptScore W2022648745C179927520 @default.
• W2022648745 hasConceptScore W2022648745C185592680 @default.
• W2022648745 hasConceptScore W2022648745C201268389 @default.
• W2022648745 hasConceptScore W2022648745C2776703722 @default.
• W2022648745 hasConceptScore W2022648745C2778370115 @default.
• W2022648745 hasConceptScore W2022648745C2780881558 @default.
• W2022648745 hasConceptScore W2022648745C43617362 @default.
• W2022648745 hasConceptScore W2022648745C55493867 @default.
• W2022648745 hasConceptScore W2022648745C71924100 @default.
• W2022648745 hasConceptScore W2022648745C86803240 @default.
• W2022648745 hasConceptScore W2022648745C97355855 @default.
• W2022648745 hasLocation W20226487451 @default.
• W2022648745 hasOpenAccess W2022648745 @default.
• W2022648745 hasPrimaryLocation W20226487451 @default.
• W2022648745 hasRelatedWork W1543763253 @default.
• W2022648745 hasRelatedWork W1970776800 @default.
• W2022648745 hasRelatedWork W1971133824 @default.
• W2022648745 hasRelatedWork W2022648745 @default.
• W2022648745 hasRelatedWork W2039678120 @default.
• W2022648745 hasRelatedWork W2046295495 @default.
• W2022648745 hasRelatedWork W2224170824 @default.
• W2022648745 hasRelatedWork W2412442195 @default.
• W2022648745 hasRelatedWork W2940238754 @default.
• W2022648745 hasRelatedWork W4290135653 @default.
• W2022648745 hasVolume "48" @default.
• W2022648745 isParatext "false" @default.
• W2022648745 isRetracted "false" @default.
• W2022648745 magId "2022648745" @default.
• W2022648745 workType "article" @default.