Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022648905> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2022648905 endingPage "1369" @default.
- W2022648905 startingPage "1363" @default.
- W2022648905 abstract "Erythraline, isolated from the bark of Erythrina crista-galli which are used as Brazilian medicine plant for the treatment of inflammation diseases, suppressed nitric oxide (NO) production and induction of inducible nitric oxide synthase (iNOS) expression in RAW264.7 cells stimulated by lipopolysaccharide (LPS). Because of Toll-like receptor (TLR) 4 and its signal transduction are indispensable to the production of NO and iNOS expression by LPS, we investigated the effects of erythraline on TLR signaling molecules. Western blot analysis revealed that the degradation of inhibitor of nuclear factor (NF)-κB (IκB) by LPS was suppressed by erythraline. Moreover, erythraline inhibited not only LPS-induced phosphorylation of IκB kinase (Ikk) but also phosphorylation of mitogen-activated protein kinases (MAPKs). However, it showed no effect on LPS -induced phosphorylation of transforming growth factor (TGF)-β-activated kinase (TAK) 1 that exists upstream of Ikk and MAPKs, and is required for the activation of these signaling molecules on TLR signaling pathway. These results suggested that erythraline might have inhibited the kinase activity of TAK1. Furthermore, these results were supported from the inhibitory pattern of erythraline on TLR signaling molecules when the cells were stimulated by TLR2 ligand, peptidoglycan which activates the same pathway as LPS on TLR signal transduction." @default.
- W2022648905 created "2016-06-24" @default.
- W2022648905 creator A5012158843 @default.
- W2022648905 creator A5065723905 @default.
- W2022648905 creator A5066470905 @default.
- W2022648905 creator A5076930309 @default.
- W2022648905 creator A5080380140 @default.
- W2022648905 date "2013-01-01" @default.
- W2022648905 modified "2023-09-26" @default.
- W2022648905 title "Inhibitory Effect of Erythraline on Toll-Like Receptor Signaling Pathway in RAW264.7 Cells" @default.
- W2022648905 cites W1483162601 @default.
- W2022648905 cites W1519633296 @default.
- W2022648905 cites W1575383081 @default.
- W2022648905 cites W1965971815 @default.
- W2022648905 cites W1969072247 @default.
- W2022648905 cites W1994391392 @default.
- W2022648905 cites W2037368492 @default.
- W2022648905 cites W2040470926 @default.
- W2022648905 cites W2057809738 @default.
- W2022648905 cites W2089938437 @default.
- W2022648905 doi "https://doi.org/10.1248/bpb.b12-00910" @default.
- W2022648905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23902980" @default.
- W2022648905 hasPublicationYear "2013" @default.
- W2022648905 type Work @default.
- W2022648905 sameAs 2022648905 @default.
- W2022648905 citedByCount "4" @default.
- W2022648905 countsByYear W20226489052018 @default.
- W2022648905 countsByYear W20226489052019 @default.
- W2022648905 countsByYear W20226489052023 @default.
- W2022648905 crossrefType "journal-article" @default.
- W2022648905 hasAuthorship W2022648905A5012158843 @default.
- W2022648905 hasAuthorship W2022648905A5065723905 @default.
- W2022648905 hasAuthorship W2022648905A5066470905 @default.
- W2022648905 hasAuthorship W2022648905A5076930309 @default.
- W2022648905 hasAuthorship W2022648905A5080380140 @default.
- W2022648905 hasBestOaLocation W20226489051 @default.
- W2022648905 hasConcept C100175707 @default.
- W2022648905 hasConcept C11960822 @default.
- W2022648905 hasConcept C134018914 @default.
- W2022648905 hasConcept C136449434 @default.
- W2022648905 hasConcept C153911025 @default.
- W2022648905 hasConcept C170493617 @default.
- W2022648905 hasConcept C184235292 @default.
- W2022648905 hasConcept C185592680 @default.
- W2022648905 hasConcept C2776070231 @default.
- W2022648905 hasConcept C2776709828 @default.
- W2022648905 hasConcept C2777622882 @default.
- W2022648905 hasConcept C2777730290 @default.
- W2022648905 hasConcept C2779730028 @default.
- W2022648905 hasConcept C2781236682 @default.
- W2022648905 hasConcept C43929388 @default.
- W2022648905 hasConcept C519581460 @default.
- W2022648905 hasConcept C55493867 @default.
- W2022648905 hasConcept C62478195 @default.
- W2022648905 hasConcept C86803240 @default.
- W2022648905 hasConcept C95444343 @default.
- W2022648905 hasConceptScore W2022648905C100175707 @default.
- W2022648905 hasConceptScore W2022648905C11960822 @default.
- W2022648905 hasConceptScore W2022648905C134018914 @default.
- W2022648905 hasConceptScore W2022648905C136449434 @default.
- W2022648905 hasConceptScore W2022648905C153911025 @default.
- W2022648905 hasConceptScore W2022648905C170493617 @default.
- W2022648905 hasConceptScore W2022648905C184235292 @default.
- W2022648905 hasConceptScore W2022648905C185592680 @default.
- W2022648905 hasConceptScore W2022648905C2776070231 @default.
- W2022648905 hasConceptScore W2022648905C2776709828 @default.
- W2022648905 hasConceptScore W2022648905C2777622882 @default.
- W2022648905 hasConceptScore W2022648905C2777730290 @default.
- W2022648905 hasConceptScore W2022648905C2779730028 @default.
- W2022648905 hasConceptScore W2022648905C2781236682 @default.
- W2022648905 hasConceptScore W2022648905C43929388 @default.
- W2022648905 hasConceptScore W2022648905C519581460 @default.
- W2022648905 hasConceptScore W2022648905C55493867 @default.
- W2022648905 hasConceptScore W2022648905C62478195 @default.
- W2022648905 hasConceptScore W2022648905C86803240 @default.
- W2022648905 hasConceptScore W2022648905C95444343 @default.
- W2022648905 hasIssue "8" @default.
- W2022648905 hasLocation W20226489051 @default.
- W2022648905 hasLocation W20226489052 @default.
- W2022648905 hasOpenAccess W2022648905 @default.
- W2022648905 hasPrimaryLocation W20226489051 @default.
- W2022648905 hasRelatedWork W1501881225 @default.
- W2022648905 hasRelatedWork W2022648905 @default.
- W2022648905 hasRelatedWork W2054538838 @default.
- W2022648905 hasRelatedWork W2071860886 @default.
- W2022648905 hasRelatedWork W2072043467 @default.
- W2022648905 hasRelatedWork W2116766330 @default.
- W2022648905 hasRelatedWork W2132137833 @default.
- W2022648905 hasRelatedWork W2167448878 @default.
- W2022648905 hasRelatedWork W2888167848 @default.
- W2022648905 hasRelatedWork W98233594 @default.
- W2022648905 hasVolume "36" @default.
- W2022648905 isParatext "false" @default.
- W2022648905 isRetracted "false" @default.
- W2022648905 magId "2022648905" @default.
- W2022648905 workType "article" @default.