FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022649585> ?p ?o ?g. }

• W2022649585 endingPage "256" @default.
• W2022649585 startingPage "241" @default.
• W2022649585 abstract "HIV-1 infection cannot be cured due to reservoirs formed early after infection. Decreasing the massive CD4+ T cell activation that occurs at the beginning of the disease would delay reservoir seeding, providing a better prognosis for patients. CD4+ T cell activation is mediated by protein kinase C (PKC) theta (θ), which is involved in T-cell proliferation, as well as NF-κB, NF-AT, and AP-1 activation. We found that PKCθ activity increased viral replication, but also that HIV-1 induced higher activation of PKCθ in infected CD4+ T cells, creating a feedback loop. Therefore, specific inhibition of PKCθ activity could contribute to control HIV-1 replication. We tested the efficacy of seven PKCθ specific inhibitors to control HIV-1 replication in CD4+ T cells and selected two of the more potent and safer: CGX1079 and CGX0471. They reduced PKCθ phosphorylation at T538 and its translocation to the plasma membrane, which correlated with decreased HIV-1 retrotranscription through partial inhibition of SAMHD1 antiviral activity, rendering lower proviral integration. CGX1079 and CGX0471 also interfered with viral transcription, which would reduce the production of new virions, as well as the subsequent spread and infection of new targets that would increase the reservoir size. CGX1079 and CGX0471 did not completely abrogate T-cell functions such as proliferation and CD8-mediated release of IFN-γ in PBMCs from HIV-infected patients, thereby avoiding general immunosuppresion. Consequently, using PKCθ inhibitors as adjuvant of antiretroviral therapy in recently infected patients would decrease the pool of activated CD4+ T cells, thwarting proviral integration and reducing the reservoir size." @default.
• W2022649585 created "2016-06-24" @default.
• W2022649585 creator A5005329204 @default.
• W2022649585 creator A5007242104 @default.
• W2022649585 creator A5039883794 @default.
• W2022649585 creator A5042219923 @default.
• W2022649585 creator A5050753288 @default.
• W2022649585 creator A5061011421 @default.
• W2022649585 creator A5063383231 @default.
• W2022649585 creator A5065131737 @default.
• W2022649585 creator A5065885408 @default.
• W2022649585 creator A5071503448 @default.
• W2022649585 date "2015-04-01" @default.
• W2022649585 modified "2023-10-09" @default.
• W2022649585 title "Analysis of protein kinase C theta inhibitors for the control of HIV-1 replication in human CD4+ T cells reveals an effect on retrotranscription in addition to viral transcription" @default.
• W2022649585 cites W143795388 @default.
• W2022649585 cites W1481377618 @default.
• W2022649585 cites W1544564404 @default.
• W2022649585 cites W1594848307 @default.
• W2022649585 cites W1596079370 @default.
• W2022649585 cites W1659719610 @default.
• W2022649585 cites W1815763197 @default.
• W2022649585 cites W1876390333 @default.
• W2022649585 cites W1888546935 @default.
• W2022649585 cites W1970662179 @default.
• W2022649585 cites W1973844670 @default.
• W2022649585 cites W1974721104 @default.
• W2022649585 cites W1978674283 @default.
• W2022649585 cites W1983108992 @default.
• W2022649585 cites W1983466424 @default.
• W2022649585 cites W1988466211 @default.
• W2022649585 cites W1989142268 @default.
• W2022649585 cites W1992007798 @default.
• W2022649585 cites W1999041896 @default.
• W2022649585 cites W1999426828 @default.
• W2022649585 cites W2004202136 @default.
• W2022649585 cites W2005588999 @default.
• W2022649585 cites W2005709737 @default.
• W2022649585 cites W2008972159 @default.
• W2022649585 cites W2009286781 @default.
• W2022649585 cites W2011626958 @default.
• W2022649585 cites W2011952922 @default.
• W2022649585 cites W2015100470 @default.
• W2022649585 cites W2019508559 @default.
• W2022649585 cites W2019676583 @default.
• W2022649585 cites W2021905358 @default.
• W2022649585 cites W2021911222 @default.
• W2022649585 cites W2026615262 @default.
• W2022649585 cites W2026814484 @default.
• W2022649585 cites W2027915750 @default.
• W2022649585 cites W2032929697 @default.
• W2022649585 cites W2035487460 @default.
• W2022649585 cites W2037267150 @default.
• W2022649585 cites W2037343680 @default.
• W2022649585 cites W2038598840 @default.
• W2022649585 cites W2038904774 @default.
• W2022649585 cites W2039096179 @default.
• W2022649585 cites W2048364030 @default.
• W2022649585 cites W2050096299 @default.
• W2022649585 cites W2050098038 @default.
• W2022649585 cites W2054678965 @default.
• W2022649585 cites W2060829964 @default.
• W2022649585 cites W2060931470 @default.
• W2022649585 cites W2062148688 @default.
• W2022649585 cites W2064977208 @default.
• W2022649585 cites W2065608903 @default.
• W2022649585 cites W2066106215 @default.
• W2022649585 cites W2066704458 @default.
• W2022649585 cites W2067680497 @default.
• W2022649585 cites W2072901265 @default.
• W2022649585 cites W2074452851 @default.
• W2022649585 cites W2081550246 @default.
• W2022649585 cites W2085307859 @default.
• W2022649585 cites W2086137483 @default.
• W2022649585 cites W2086312582 @default.
• W2022649585 cites W2087809591 @default.
• W2022649585 cites W2088358220 @default.
• W2022649585 cites W2090320233 @default.
• W2022649585 cites W2090646713 @default.
• W2022649585 cites W2090757010 @default.
• W2022649585 cites W2093853778 @default.
• W2022649585 cites W2094583956 @default.
• W2022649585 cites W2099356858 @default.
• W2022649585 cites W2101151400 @default.
• W2022649585 cites W2105841943 @default.
• W2022649585 cites W2106224747 @default.
• W2022649585 cites W2112003322 @default.
• W2022649585 cites W2114651496 @default.
• W2022649585 cites W2124114936 @default.
• W2022649585 cites W2130560337 @default.
• W2022649585 cites W2132823255 @default.
• W2022649585 cites W2134663557 @default.
• W2022649585 cites W2135816279 @default.
• W2022649585 cites W2137154569 @default.
• W2022649585 cites W2139119391 @default.
• W2022649585 cites W2139250164 @default.
• W2022649585 cites W2140092746 @default.
• W2022649585 cites W2140381887 @default.

• next