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• W2022649785 abstract "Epidemiological studies have proposed that depression may increase the risk for Alzheimer's disease (AD), even in patients with early-onset depression. Although metabolism of amyloid β protein (Aβ) in elderly depression received attention in terms of their correlation, there is a serious heterogeneity in elderly depression in terms of age at onset of depression. Moreover, it is unknown whether early-onset major depressive disorder (MDD) has a long-term effect on the involvement of Aβ metabolism and later development of AD. Thus, we evaluated serum Aβ40 and Aβ42 levels, the Aβ40/Aβ42 ratio in 89 elderly (≥ 60 years of age) inpatients with MDD and 81 age-matched healthy controls, and compared them among patients with early-onset (< 60 years) and late-onset (≥ 60 years) MDD and controls. The results showed that the serum Aβ40/Aβ42 ratio was significantly higher in patients with both early- and late-onset MDD than in controls (early-onset, p = 0.010; late-onset, p = 0.043), and it is of great interest that the serum Aβ40/Aβ42 ratio was negatively correlated with the age at MDD onset (R = − 0.201, p = 0.032). These results suggest that an earlier onset of MDD may have a more serious abnormality in Aβ metabolism, possibly explaining a biological mechanism underlying the link between depression and AD." @default.
• W2022649785 created "2016-06-24" @default.
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• W2022649785 date "2013-06-01" @default.
• W2022649785 modified "2023-10-01" @default.
• W2022649785 title "Heterogeneity of elderly depression: Increased risk of Alzheimer's disease and Aβ protein metabolism" @default.
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• W2022649785 doi "https://doi.org/10.1016/j.pnpbp.2012.12.016" @default.
• W2022649785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23276885" @default.
• W2022649785 hasPublicationYear "2013" @default.
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