FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022650254> ?p ?o ?g. }

• W2022650254 endingPage "e666" @default.
• W2022650254 startingPage "e666" @default.
• W2022650254 abstract "Armigeres subalbatus is a natural vector of the filarial worm Brugia pahangi, but it kills Brugia malayi microfilariae by melanotic encapsulation. Because B. malayi and B. pahangi are morphologically and biologically similar, comparing Ar. subalbatus-B. pahangi susceptibility and Ar. subalbatus-B. malayi refractoriness could provide significant insight into recognition mechanisms required to mount an effective anti-filarial worm immune response in the mosquito, as well as provide considerable detail into the molecular components involved in vector competence. Previously, we assessed the transcriptional response of Ar. subalbatus to B. malayi, and now we report transcriptome profiling studies of Ar. subalbatus in relation to filarial worm infection to provide information on the molecular components involved in B. pahangi susceptibility.Utilizing microarrays, comparisons were made between mosquitoes exposed to B. pahangi, B. malayi, and uninfected bloodmeals. The time course chosen facilitated an examination of key events in the development of the parasite, beginning with the very start of filarial worm infection and spanning to well after parasites had developed to the infective stage in the mosquito. At 1, 3, 6, 12, 24 h post infection and 2-3, 5-6, 8-9, and 13-14 days post challenge there were 31, 75, 113, 76, 54, 5, 3, 13, and 2 detectable transcripts, respectively, with significant differences in transcript abundance (increase or decrease) as a result of parasite development.Herein, we demonstrate that filarial worm susceptibility in a laboratory strain of the natural vector Ar. subalbatus involves many factors of both known and unknown function that most likely are associated with filarial worm penetration through the midgut, invasion into thoracic muscle cells, and maintenance of homeostasis in the hemolymph environment. The data show that there are distinct and separate transcriptional patterns associated with filarial worm susceptibility as compared to refractoriness, and that an infection response in Ar. subalbatus can differ significantly from that observed in Ae. aegypti, a common laboratory model." @default.
• W2022650254 created "2016-06-24" @default.
• W2022650254 creator A5003468882 @default.
• W2022650254 creator A5005834522 @default.
• W2022650254 creator A5012534121 @default.
• W2022650254 creator A5026668775 @default.
• W2022650254 creator A5070697792 @default.
• W2022650254 creator A5079563722 @default.
• W2022650254 creator A5082096007 @default.
• W2022650254 date "2010-04-20" @default.
• W2022650254 modified "2023-09-23" @default.
• W2022650254 title "Mosquito Transcriptome Profiles and Filarial Worm Susceptibility in Armigeres subalbatus" @default.
• W2022650254 cites W1547074150 @default.
• W2022650254 cites W1592493077 @default.
• W2022650254 cites W1601252917 @default.
• W2022650254 cites W1968991425 @default.
• W2022650254 cites W1970156673 @default.
• W2022650254 cites W1972490957 @default.
• W2022650254 cites W1975818740 @default.
• W2022650254 cites W1977531463 @default.
• W2022650254 cites W1981389417 @default.
• W2022650254 cites W1982202219 @default.
• W2022650254 cites W1985355495 @default.
• W2022650254 cites W1994181567 @default.
• W2022650254 cites W1994429610 @default.
• W2022650254 cites W1998127022 @default.
• W2022650254 cites W1998326708 @default.
• W2022650254 cites W2006849849 @default.
• W2022650254 cites W2013385330 @default.
• W2022650254 cites W2016373666 @default.
• W2022650254 cites W2019211309 @default.
• W2022650254 cites W2023739559 @default.
• W2022650254 cites W2041259751 @default.
• W2022650254 cites W2047618439 @default.
• W2022650254 cites W2053589941 @default.
• W2022650254 cites W2054627768 @default.
• W2022650254 cites W2063838707 @default.
• W2022650254 cites W2064003574 @default.
• W2022650254 cites W2065912508 @default.
• W2022650254 cites W2067385113 @default.
• W2022650254 cites W2070581078 @default.
• W2022650254 cites W2083085665 @default.
• W2022650254 cites W2089550565 @default.
• W2022650254 cites W2089900609 @default.
• W2022650254 cites W2091075474 @default.
• W2022650254 cites W2094046337 @default.
• W2022650254 cites W2094344053 @default.
• W2022650254 cites W2096769978 @default.
• W2022650254 cites W2098429428 @default.
• W2022650254 cites W2102760505 @default.
• W2022650254 cites W2111362489 @default.
• W2022650254 cites W2118030557 @default.
• W2022650254 cites W2122000315 @default.
• W2022650254 cites W2122226340 @default.
• W2022650254 cites W2123469465 @default.
• W2022650254 cites W2127924248 @default.
• W2022650254 cites W2133723917 @default.
• W2022650254 cites W2140113867 @default.
• W2022650254 cites W2143175631 @default.
• W2022650254 cites W2156333745 @default.
• W2022650254 cites W2157460522 @default.
• W2022650254 cites W2159033700 @default.
• W2022650254 cites W2170681488 @default.
• W2022650254 cites W2170932122 @default.
• W2022650254 cites W2312537902 @default.
• W2022650254 cites W2320367390 @default.
• W2022650254 cites W2330316851 @default.
• W2022650254 cites W2343955585 @default.
• W2022650254 cites W2507269450 @default.
• W2022650254 cites W4300843792 @default.
• W2022650254 doi "https://doi.org/10.1371/journal.pntd.0000666" @default.
• W2022650254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2857672" @default.
• W2022650254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20421927" @default.
• W2022650254 hasPublicationYear "2010" @default.
• W2022650254 type Work @default.
• W2022650254 sameAs 2022650254 @default.
• W2022650254 citedByCount "37" @default.
• W2022650254 countsByYear W20226502542012 @default.
• W2022650254 countsByYear W20226502542013 @default.
• W2022650254 countsByYear W20226502542014 @default.
• W2022650254 countsByYear W20226502542015 @default.
• W2022650254 countsByYear W20226502542016 @default.
• W2022650254 countsByYear W20226502542018 @default.
• W2022650254 countsByYear W20226502542020 @default.
• W2022650254 countsByYear W20226502542021 @default.
• W2022650254 countsByYear W20226502542022 @default.
• W2022650254 countsByYear W20226502542023 @default.
• W2022650254 crossrefType "journal-article" @default.
• W2022650254 hasAuthorship W2022650254A5003468882 @default.
• W2022650254 hasAuthorship W2022650254A5005834522 @default.
• W2022650254 hasAuthorship W2022650254A5012534121 @default.
• W2022650254 hasAuthorship W2022650254A5026668775 @default.
• W2022650254 hasAuthorship W2022650254A5070697792 @default.
• W2022650254 hasAuthorship W2022650254A5079563722 @default.
• W2022650254 hasAuthorship W2022650254A5082096007 @default.
• W2022650254 hasBestOaLocation W20226502541 @default.
• W2022650254 hasConcept C104317684 @default.
• W2022650254 hasConcept C136764020 @default.

• next