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• W2022650354 abstract "Fetal-neonatal iron deficiency acutely alters hippocampal biochemistry, neural morphology, and electrophysiology accompanied by a downregulation of brain-derived neurotrophic factor (BDNF). These changes provide a cellular and molecular basis for observed short-term learning and memory impairments. However, the etiology of residual, long-term hippocampal neurotransmission abnormalities and learning impairments after treatment remain unclear. Because BDNF modulates learning and memory, we assessed its expression in 65-d-old formerly iron deficient (FID) male rats that had been iron deficient during the fetal-neonatal period and treated with iron since postnatal day 7. BDNF-III and -IV mRNAs and BDNF protein expression remained down-regulated in FID rats when compared with the always iron-sufficient rats. Expressions of BDNF activity-dependent downstream targets (3-hydroxy-3-methylglutaryl CoA reductase and immediate early genes c-fos, early growth response gene 1 and 2) were reduced in FID rats. In turn, hippocampal expressions of direct targets of early-growth response genes, including hypoxia-inducible factor 1, dual-specificity phosphatase 4, IGF 2, and myelin basic protein were also diminished in FID rats. Collectively, fetal-neonatal iron deficiency lowers hippocampal BDNF expression and function beyond the period of iron deficiency. These findings may underlie the persistence of learning deficits seen after fetal-neonatal iron deficiency." @default.
• W2022650354 created "2016-06-24" @default.
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• W2022650354 date "2009-05-01" @default.
• W2022650354 modified "2023-10-11" @default.
• W2022650354 title "Long-Term Reduction of Hippocampal Brain-Derived Neurotrophic Factor Activity After Fetal-Neonatal Iron Deficiency in Adult Rats" @default.
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• W2022650354 doi "https://doi.org/10.1203/pdr.0b013e31819d90a1" @default.
• W2022650354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2715440" @default.
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