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- W2022650388 abstract "We have developed the recombinant baculovirus pseudotyped with vesicular stomatitis virus (VSV) G protein. The VSV-G gene was under the control of the polyhedrin promoter so that it was expressed at high levels in infected insect cells but not in mammalian cells. The presence of VSV-G protein in purified baculovirus preparations was confirmed by Western analysis. This recombinant baculovirus also carried human AFP (α-fetoprotein) promoter for hepatocyte-specific gene expression. After an in vitro infection by a recombinant baculovirus carrying the luciferase gene under the control of human AFP promoter/enhancer (BacG-AFP-Luc+), the luciferase gene was expressed in AFP-producing Huh7, Hep3B, and HepG2 cell lines, but not in AFP-nonproducing cell lines. BacG-AFP-Luc+ transduced with human hepatoma cells in vitro at an efficiency about fivefold greater than the recombinant baculovirus lacking VSV-G (the virus Bac-AFP-Luc+). The utilization of the AFP promoter/enhancer in a baculovirus vector could provide benefits in gene therapy applications." @default.
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- W2022650388 date "2001-11-01" @default.
- W2022650388 modified "2023-10-17" @default.
- W2022650388 title "Hepatocyte-Specific Gene Expression by Baculovirus Pseudotyped with Vesicular Stomatitis Virus Envelope Glycoprotein" @default.
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- W2022650388 doi "https://doi.org/10.1006/bbrc.2001.6009" @default.
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