Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022651196> ?p ?o ?g. }
- W2022651196 endingPage "478" @default.
- W2022651196 startingPage "465" @default.
- W2022651196 abstract "Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-α/β and -λ. Surprisingly, patients with a defect of IRAK-4, a critical kinase downstream from TLRs, are resistant to common viruses. We show here that IFN-α/β and -λ induction via TLR-7, TLR-8, and TLR-9 was abolished in IRAK-4-deficient blood cells. In contrast, IFN-α/β and -λ were induced normally by TLR-3 and TLR-4 agonists. Moreover, IFN-β and -λ were normally induced by TLR-3 agonists and viruses in IRAK-4-deficient fibroblasts. We further show that IFN-α/β and -λ production in response to 9 of 11 viruses tested was normal or weakly affected in IRAK-4-deficient blood cells. Thus, IRAK-4-deficient patients may control viral infections by TLR-3- and TLR-4-dependent and/or TLR-independent production of IFNs. The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-α/β and -λ is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans." @default.
- W2022651196 created "2016-06-24" @default.
- W2022651196 creator A5010363328 @default.
- W2022651196 creator A5013797518 @default.
- W2022651196 creator A5015763043 @default.
- W2022651196 creator A5016649272 @default.
- W2022651196 creator A5017339200 @default.
- W2022651196 creator A5018211571 @default.
- W2022651196 creator A5019573704 @default.
- W2022651196 creator A5023101549 @default.
- W2022651196 creator A5024359434 @default.
- W2022651196 creator A5031624178 @default.
- W2022651196 creator A5035683885 @default.
- W2022651196 creator A5038677194 @default.
- W2022651196 creator A5047928635 @default.
- W2022651196 creator A5050247627 @default.
- W2022651196 creator A5062601012 @default.
- W2022651196 creator A5062885345 @default.
- W2022651196 creator A5063790935 @default.
- W2022651196 creator A5063999287 @default.
- W2022651196 creator A5069253954 @default.
- W2022651196 creator A5070931454 @default.
- W2022651196 creator A5071389917 @default.
- W2022651196 creator A5077580993 @default.
- W2022651196 creator A5081727354 @default.
- W2022651196 creator A5082174975 @default.
- W2022651196 creator A5082652348 @default.
- W2022651196 creator A5085234051 @default.
- W2022651196 creator A5086250654 @default.
- W2022651196 creator A5089202681 @default.
- W2022651196 date "2005-11-01" @default.
- W2022651196 modified "2023-10-12" @default.
- W2022651196 title "Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses" @default.
- W2022651196 cites W1502575492 @default.
- W2022651196 cites W1514540900 @default.
- W2022651196 cites W1526363252 @default.
- W2022651196 cites W1628777611 @default.
- W2022651196 cites W1676806089 @default.
- W2022651196 cites W1895807078 @default.
- W2022651196 cites W1917885467 @default.
- W2022651196 cites W1919093559 @default.
- W2022651196 cites W1955412606 @default.
- W2022651196 cites W1968336033 @default.
- W2022651196 cites W1969072247 @default.
- W2022651196 cites W1969430178 @default.
- W2022651196 cites W1972327788 @default.
- W2022651196 cites W1972776583 @default.
- W2022651196 cites W1973472843 @default.
- W2022651196 cites W1974623065 @default.
- W2022651196 cites W1977921022 @default.
- W2022651196 cites W1987293324 @default.
- W2022651196 cites W1991236592 @default.
- W2022651196 cites W1993056035 @default.
- W2022651196 cites W1994391392 @default.
- W2022651196 cites W1999869434 @default.
- W2022651196 cites W2004183112 @default.
- W2022651196 cites W2004465286 @default.
- W2022651196 cites W2009392385 @default.
- W2022651196 cites W2010508808 @default.
- W2022651196 cites W2022273444 @default.
- W2022651196 cites W2027685458 @default.
- W2022651196 cites W2030032523 @default.
- W2022651196 cites W2030611349 @default.
- W2022651196 cites W2033081825 @default.
- W2022651196 cites W2033431215 @default.
- W2022651196 cites W2034275921 @default.
- W2022651196 cites W2041521914 @default.
- W2022651196 cites W2046783872 @default.
- W2022651196 cites W2049874360 @default.
- W2022651196 cites W2052106057 @default.
- W2022651196 cites W2056107229 @default.
- W2022651196 cites W2057884259 @default.
- W2022651196 cites W2065694999 @default.
- W2022651196 cites W2069981713 @default.
- W2022651196 cites W2076361525 @default.
- W2022651196 cites W2078811876 @default.
- W2022651196 cites W2079295092 @default.
- W2022651196 cites W2084880831 @default.
- W2022651196 cites W2085237060 @default.
- W2022651196 cites W2091554591 @default.
- W2022651196 cites W2092250990 @default.
- W2022651196 cites W2104904748 @default.
- W2022651196 cites W2104957057 @default.
- W2022651196 cites W2109686486 @default.
- W2022651196 cites W2116692899 @default.
- W2022651196 cites W2120388636 @default.
- W2022651196 cites W2130421043 @default.
- W2022651196 cites W2134847649 @default.
- W2022651196 cites W2138432152 @default.
- W2022651196 cites W2138677670 @default.
- W2022651196 cites W2140375278 @default.
- W2022651196 cites W2141040025 @default.
- W2022651196 cites W2144787399 @default.
- W2022651196 cites W2157135427 @default.
- W2022651196 cites W2161208630 @default.
- W2022651196 cites W2161733562 @default.
- W2022651196 cites W2163353465 @default.
- W2022651196 cites W2168329857 @default.