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- W2022652134 abstract "Abstract Background Squamous cell carcinoma ( SCC ) in situ may be transected in a superficial biopsy, which makes it difficult to distinguish between in situ and invasive carcinoma. This study investigated the frequency of invasive SCC in transected SCC in situ referred for M ohs surgery. Methods A retrospective chart review was performed to identify subjects with biopsy‐proven, transected SCC in situ referred for M ohs surgery. The incidence of invasion, histologic variables, preoperative and intraoperative correlations, and clinical factors were determined and recorded. Results Of 51 cases identified, five (9.8%) were found to harbor invasive SCC , 15 (29.4%) showed SCC in situ , and 28 (54.9%) showed evidence of scarring, inflammation, or actinic keratosis at the prior biopsy site. Invasive lesions required significantly more stages of M ohs surgery to obtain tumor clearance but were similar with regard to patient age, symptoms, and family and personal histories of skin cancer. Preoperative lesion size and duration were greater in invasive cases, but these differences did not reach statistical significance. Conclusions A small number of transected SCC s in situ , to which the caveat “invasion cannot be ruled out” can be applied, have an invasive component that is identified during M ohs surgery. Definitive treatment choices should depend on the physician's impression, the clinical characteristics of the lesion, tumor location, patient comorbidities, and patient desires." @default.
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- W2022652134 date "2015-04-27" @default.
- W2022652134 modified "2023-10-15" @default.
- W2022652134 title "Frequency of squamous cell carcinoma (SCC) invasion in transected SCC<i>in situ</i>referred for Mohs surgery: the Dartmouth−Hitchcock experience" @default.
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- W2022652134 doi "https://doi.org/10.1111/ijd.12867" @default.
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