Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022652364> ?p ?o ?g. }
- W2022652364 endingPage "12" @default.
- W2022652364 startingPage "1" @default.
- W2022652364 abstract "As cellular models for in vitro liver cancer and toxicity studies, HepG2 and Hep3B are the two most frequently used liver cancer cell lines. Because of their similarities they are often treated as the same in experimental studies. However, there are many differences that have been largely over-sighted or ignored between them. In this review, we summarize the differences between HepG2 and Hep3B cell lines that can be found in the literature based on PubMed search. We particularly focus on the differential gene expression, differential drug responses (chemosensitivity, cell cycle and growth inhibition, and gene induction), signaling pathways associated with these differences, as well as the factors in governing these differences between HepG2 and Hep3B cell lines. Based on our analyses of the available data, we suggest that neither HBx nor p53 may be the crucial factor to determine the differences between HepG2 and Hep3B cell lines although HBx regulates the expression of the majority of genes that are differentially expressed between HepG2 and Hep3B. Instead, the different maturation stages in cancer development of the original specimen between HepG2 and Hep3B may be responsible for the differences between them. This review provides insight into the molecular mechanisms underlying the differences between HepG2 and Hep3B and help investigators especially the beginners in the areas of liver cancer research and drug metabolism to fully understand, and thus better use and interpret the data from these two cell lines in their studies." @default.
- W2022652364 created "2016-06-24" @default.
- W2022652364 creator A5007170702 @default.
- W2022652364 creator A5016031839 @default.
- W2022652364 creator A5022427493 @default.
- W2022652364 creator A5033632697 @default.
- W2022652364 creator A5062320569 @default.
- W2022652364 creator A5076494252 @default.
- W2022652364 date "2014-07-08" @default.
- W2022652364 modified "2023-10-02" @default.
- W2022652364 title "Distinctive pharmacological differences between liver cancer cell lines HepG2 and Hep3B" @default.
- W2022652364 cites W1507923077 @default.
- W2022652364 cites W158638529 @default.
- W2022652364 cites W1838206574 @default.
- W2022652364 cites W1840646292 @default.
- W2022652364 cites W1924035549 @default.
- W2022652364 cites W1964647119 @default.
- W2022652364 cites W1967173409 @default.
- W2022652364 cites W1967822239 @default.
- W2022652364 cites W1972934590 @default.
- W2022652364 cites W1973615601 @default.
- W2022652364 cites W1978272694 @default.
- W2022652364 cites W1985239808 @default.
- W2022652364 cites W1985795036 @default.
- W2022652364 cites W1986049089 @default.
- W2022652364 cites W1988254502 @default.
- W2022652364 cites W1989312510 @default.
- W2022652364 cites W1990849031 @default.
- W2022652364 cites W1991961027 @default.
- W2022652364 cites W1992230103 @default.
- W2022652364 cites W2001158436 @default.
- W2022652364 cites W2001817269 @default.
- W2022652364 cites W2003992176 @default.
- W2022652364 cites W2004869810 @default.
- W2022652364 cites W2008365696 @default.
- W2022652364 cites W2008791994 @default.
- W2022652364 cites W2008902243 @default.
- W2022652364 cites W2011257176 @default.
- W2022652364 cites W2011566383 @default.
- W2022652364 cites W2013951470 @default.
- W2022652364 cites W2014857894 @default.
- W2022652364 cites W2015702695 @default.
- W2022652364 cites W2016079394 @default.
- W2022652364 cites W2016360721 @default.
- W2022652364 cites W2020002352 @default.
- W2022652364 cites W2021938834 @default.
- W2022652364 cites W2023623233 @default.
- W2022652364 cites W2025958629 @default.
- W2022652364 cites W2026581504 @default.
- W2022652364 cites W2030142625 @default.
- W2022652364 cites W2032114319 @default.
- W2022652364 cites W2032222439 @default.
- W2022652364 cites W2035312783 @default.
- W2022652364 cites W2040613440 @default.
- W2022652364 cites W2044227221 @default.
- W2022652364 cites W2045091103 @default.
- W2022652364 cites W2045463981 @default.
- W2022652364 cites W2047141741 @default.
- W2022652364 cites W2047929370 @default.
- W2022652364 cites W2047957855 @default.
- W2022652364 cites W2056096759 @default.
- W2022652364 cites W2057211093 @default.
- W2022652364 cites W2060576011 @default.
- W2022652364 cites W2060869819 @default.
- W2022652364 cites W2065676091 @default.
- W2022652364 cites W2067224679 @default.
- W2022652364 cites W2067831243 @default.
- W2022652364 cites W2071572727 @default.
- W2022652364 cites W2072585523 @default.
- W2022652364 cites W2073372353 @default.
- W2022652364 cites W2076486071 @default.
- W2022652364 cites W2076785899 @default.
- W2022652364 cites W2077623588 @default.
- W2022652364 cites W2082390138 @default.
- W2022652364 cites W2082580788 @default.
- W2022652364 cites W2085543458 @default.
- W2022652364 cites W2093157637 @default.
- W2022652364 cites W2093490162 @default.
- W2022652364 cites W2097246559 @default.
- W2022652364 cites W2099215442 @default.
- W2022652364 cites W2099322971 @default.
- W2022652364 cites W2111714805 @default.
- W2022652364 cites W2127163321 @default.
- W2022652364 cites W2128670495 @default.
- W2022652364 cites W2128839685 @default.
- W2022652364 cites W2128871289 @default.
- W2022652364 cites W2132221280 @default.
- W2022652364 cites W2133568527 @default.
- W2022652364 cites W2134355392 @default.
- W2022652364 cites W2140551998 @default.
- W2022652364 cites W2143369248 @default.
- W2022652364 cites W2153558905 @default.
- W2022652364 cites W2165500094 @default.
- W2022652364 cites W2167460988 @default.
- W2022652364 cites W2314837988 @default.
- W2022652364 cites W2334013452 @default.
- W2022652364 cites W408517226 @default.
- W2022652364 cites W4211067702 @default.