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- W2022654192 abstract "Complexes of tretinoin with β-cyclodextrin, hydroxypropyl β-cyclodextrin and dimethyl β-cyclodextrin were prepared by dissolving the products in suitable organo-aqueous solvents under nitrogen and sheltered from light and then stirred for 8 days. The solvents were then evaporated, the free tretinoin eliminated and the complexes dried. Characterization of the products was carried out by electron scanning microscopy, differential scanning calorimetry, IR spectrophotometry, X-ray analysis and 1H-NMR study, which confirmed the existence of an inclusion compound but with weak affinity between tretinoin and the different cyclodextrins. Tretinoin solubility was dramatically enhanced by inclusion, especially in dimethyl β-cyclodextrin. However, in every case, the dissolved products dissociated more or less rapidly leading to reprecipitation of free tretinoin." @default.
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- W2022654192 date "1997-07-30" @default.
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- W2022654192 title "Inclusion complexes of tretinoin with cyclodextrins" @default.
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- W2022654192 doi "https://doi.org/10.1016/s0378-5173(97)00104-x" @default.
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