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- W2022656546 abstract "Growth retardation has long been known to be a major characteristic in selenium-intoxicated animals. As selenium is known to accumulate in the anterior pituitary, especially in the secretory granules of the somatotroph, we have investigated the GH secretion after GH-releasing factor 40 stimulation and the somatomedin C secretion in young male rats exposed to 15 mg sodium selenite/liter drinking water. The immediate output to 900 ± 120 ng/ml GH in control animals was reduced to 200 ± 69.4 ng/ml in selenium-treated animals. The somatomedin C level was reduced from 720 ± 16 ng/ml in control to 119 ± 17 ng/ml in selenium-treated animals. Both differences were highly significant. These findings suggest that growth retardation in selenium-treated rats could be mediated by reduced GH and somatomedin C production. (Endocrinology120: 659–663,1987)" @default.
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- W2022656546 date "1987-02-01" @default.
- W2022656546 modified "2023-09-27" @default.
- W2022656546 title "Evidence that Selenium Induces Growth Retardation through Reduced Growth Hormone and Somatomedin C Production*" @default.
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- W2022656546 doi "https://doi.org/10.1210/endo-120-2-659" @default.
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