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• W2022657319 endingPage "424" @default.
• W2022657319 startingPage "420" @default.
• W2022657319 abstract "The present study investigated the binding interaction between an antiviral drug, valacyclovir and calf thymus DNA (CT-DNA) using emission, absorption, circular dichroism, viscosity and DNA melting studies. In fluorimetric studies, thermodynamic enhancement constant (K(D)) and bimolecular enhancement constant (K(B)) were calculated at different temperatures and demonstrated that fluorescence enhancement is not initiated by a dynamic process, but instead by a static process that involves complex DNA formation in the ground state. Further, the enthalpy and entropy of the reaction between the drug and CT-DNA showed that the reaction is exothermic and enthalpy-favored. In addition, detectable changes in the circular dichroism spectrum of CT-DNA in the presence of valacyclovir indicated conformational changes in the DNA double helix following interaction with the drug. All these results prove that this antiviral drug interacts with CT-DNA via an intercalative mode of binding." @default.
• W2022657319 created "2016-06-24" @default.
• W2022657319 creator A5013813835 @default.
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• W2022657319 creator A5017588599 @default.
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• W2022657319 creator A5079776344 @default.
• W2022657319 date "2011-12-01" @default.
• W2022657319 modified "2023-10-16" @default.
• W2022657319 title "Multispectroscopic studies of the interaction of calf thymus DNA with the anti-viral drug, valacyclovir" @default.
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• W2022657319 doi "https://doi.org/10.1016/j.saa.2011.08.056" @default.
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