Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022659284> ?p ?o ?g. }
- W2022659284 endingPage "e1000976" @default.
- W2022659284 startingPage "e1000976" @default.
- W2022659284 abstract "We report a computational approach that integrates structural bioinformatics, molecular modelling and systems biology to construct a drug-target network on a structural proteome-wide scale. The approach has been applied to the genome of Mycobacterium tuberculosis (M.tb), the causative agent of one of today's most widely spread infectious diseases. The resulting drug-target interaction network for all structurally characterized approved drugs bound to putative M.tb receptors, we refer to as the ‘TB-drugome’. The TB-drugome reveals that approximately one-third of the drugs examined have the potential to be repositioned to treat tuberculosis and that many currently unexploited M.tb receptors may be chemically druggable and could serve as novel anti-tubercular targets. Furthermore, a detailed analysis of the TB-drugome has shed new light on the controversial issues surrounding drug-target networks [1]–[3]. Indeed, our results support the idea that drug-target networks are inherently modular, and further that any observed randomness is mainly caused by biased target coverage. The TB-drugome (http://funsite.sdsc.edu/drugome/TB) has the potential to be a valuable resource in the development of safe and efficient anti-tubercular drugs. More generally the methodology may be applied to other pathogens of interest with results improving as more of their structural proteomes are determined through the continued efforts of structural biology/genomics." @default.
- W2022659284 created "2016-06-24" @default.
- W2022659284 creator A5006217473 @default.
- W2022659284 creator A5015550435 @default.
- W2022659284 creator A5030652794 @default.
- W2022659284 creator A5051041953 @default.
- W2022659284 creator A5066245750 @default.
- W2022659284 creator A5079981881 @default.
- W2022659284 date "2010-11-04" @default.
- W2022659284 modified "2023-10-07" @default.
- W2022659284 title "The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications" @default.
- W2022659284 cites W1504533062 @default.
- W2022659284 cites W1544009106 @default.
- W2022659284 cites W1556758605 @default.
- W2022659284 cites W1839665474 @default.
- W2022659284 cites W1895993106 @default.
- W2022659284 cites W1966342871 @default.
- W2022659284 cites W1968531209 @default.
- W2022659284 cites W1970927928 @default.
- W2022659284 cites W1971192547 @default.
- W2022659284 cites W1972821149 @default.
- W2022659284 cites W1976239530 @default.
- W2022659284 cites W1976402681 @default.
- W2022659284 cites W1976855067 @default.
- W2022659284 cites W1977859620 @default.
- W2022659284 cites W1982554150 @default.
- W2022659284 cites W1983181721 @default.
- W2022659284 cites W1983202741 @default.
- W2022659284 cites W1985755631 @default.
- W2022659284 cites W1986087295 @default.
- W2022659284 cites W1990495809 @default.
- W2022659284 cites W1992578437 @default.
- W2022659284 cites W1992583240 @default.
- W2022659284 cites W1993795323 @default.
- W2022659284 cites W1995498227 @default.
- W2022659284 cites W1998495168 @default.
- W2022659284 cites W2003806043 @default.
- W2022659284 cites W2005861260 @default.
- W2022659284 cites W2007184315 @default.
- W2022659284 cites W2008374286 @default.
- W2022659284 cites W2009010596 @default.
- W2022659284 cites W2009313526 @default.
- W2022659284 cites W2010421805 @default.
- W2022659284 cites W2015147525 @default.
- W2022659284 cites W2016401253 @default.
- W2022659284 cites W2018408116 @default.
- W2022659284 cites W2023184347 @default.
- W2022659284 cites W2024908724 @default.
- W2022659284 cites W2025742642 @default.
- W2022659284 cites W2029980980 @default.
- W2022659284 cites W2033591223 @default.
- W2022659284 cites W2037575546 @default.
- W2022659284 cites W2044172420 @default.
- W2022659284 cites W2048080607 @default.
- W2022659284 cites W2051068375 @default.
- W2022659284 cites W2052262181 @default.
- W2022659284 cites W2059546521 @default.
- W2022659284 cites W2062173234 @default.
- W2022659284 cites W2065394359 @default.
- W2022659284 cites W2074192927 @default.
- W2022659284 cites W2075000963 @default.
- W2022659284 cites W2076764146 @default.
- W2022659284 cites W2079530723 @default.
- W2022659284 cites W2081306806 @default.
- W2022659284 cites W2093313266 @default.
- W2022659284 cites W2095533132 @default.
- W2022659284 cites W2097642323 @default.
- W2022659284 cites W2103101707 @default.
- W2022659284 cites W2113201746 @default.
- W2022659284 cites W2115076532 @default.
- W2022659284 cites W2116117181 @default.
- W2022659284 cites W2116249365 @default.
- W2022659284 cites W2117112680 @default.
- W2022659284 cites W2119069290 @default.
- W2022659284 cites W2121175754 @default.
- W2022659284 cites W2121604817 @default.
- W2022659284 cites W2124817994 @default.
- W2022659284 cites W2125112523 @default.
- W2022659284 cites W2126236256 @default.
- W2022659284 cites W2127257007 @default.
- W2022659284 cites W2128482141 @default.
- W2022659284 cites W2130479394 @default.
- W2022659284 cites W2132473872 @default.
- W2022659284 cites W2133035849 @default.
- W2022659284 cites W2133114049 @default.
- W2022659284 cites W2138512826 @default.
- W2022659284 cites W2140354550 @default.
- W2022659284 cites W2142907906 @default.
- W2022659284 cites W2144477832 @default.
- W2022659284 cites W2146839864 @default.
- W2022659284 cites W2153838454 @default.
- W2022659284 cites W2154896031 @default.
- W2022659284 cites W2154975605 @default.
- W2022659284 cites W2158789571 @default.
- W2022659284 cites W2162011385 @default.
- W2022659284 cites W2166550586 @default.
- W2022659284 cites W2170146596 @default.
- W2022659284 cites W3103786587 @default.