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- W2022665654 abstract "All mammalian cells depend on polyamines for normal growth and proliferation, but the exact roles of polyamines at the molecular level remain largely unknown. The RNA-binding protein HuR modulates the stability and translation of many target mRNAs. Here, we show that in rat intestinal epithelial cells (IECs), polyamines enhanced HuR association with the 3'-untranslated region of the c-Myc mRNA by increasing HuR phosphorylation by Chk2, in turn promoting c-Myc translation. Depletion of cellular polyamines inhibited Chk2 and reduced the affinity of HuR for c-Myc mRNA; these effects were completely reversed by addition of the polyamine putrescine or by Chk2 overexpression. In cells with high content of cellular polyamines, HuR silencing or Chk2 silencing reduced c-Myc translation and c-Myc expression levels. Our findings demonstrate that polyamines regulate c-Myc translation in IECs through HuR phosphorylation by Chk2 and provide new insight into the molecular functions of cellular polyamines." @default.
- W2022665654 created "2016-06-24" @default.
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- W2022665654 date "2009-12-01" @default.
- W2022665654 modified "2023-10-12" @default.
- W2022665654 title "Polyamines Regulate c-Myc Translation through Chk2-dependent HuR Phosphorylation" @default.
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- W2022665654 doi "https://doi.org/10.1091/mbc.e09-07-0550" @default.
- W2022665654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2785732" @default.
- W2022665654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19812253" @default.
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