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• W2022666564 endingPage "312" @default.
• W2022666564 startingPage "289" @default.
• W2022666564 abstract "The development of a cell-culture system for the cloning and clonal differentiation of different types of blood cell has made it possible to identify: (i), the proteins that regulate growth and differentiation of different cell lineages in normal and leukaemic blood cells; (ii), the molecular basis of normal and abnormal control of cell development in blood-forming tissue; and (iii), how to suppress malignancy in leukaemic cells. By using myeloid blood cells as a model system, it has been shown that normal blood cells require different proteins to induce cell viability and multiplication (growth-inducers) and differentiation (differentiation-inducers), that there is a hierarchy of growth-inducers which act at various stages of cell development, and that a growth-inducer can switch on production of a differentiation-inducer. Gene cloning has established a multigene family for these proteins. Identification of these proteins and their interaction has shown how growth and differentiation are regulated in normal development and demonstrated the mechanisms that uncouple growth and differentiation so as to produce malignant cells. Normal cells require an external source of growth-inducing protein for cell viability and multiplication. Cells can become leukaemic by genetically changing this normal requirement for growth without blocking response to normal differentiation-inducers. The mature cells induced by adding these normal protein-inducers are then no longer malignant. Other genetic changes which inhibit differentiation by the normal blood-cell regulatory proteins can occur in the evolution of leukaemia. But even these leukaemic cells may still be induced to differentiate by other compounds that can induce differentiation by alternative pathways. The differentiation of leukaemic to mature cells, which stops the cells from multiplying, results in the suppression of malignancy by bypassing genetic changes that produce the malignant phenotype. The activity of blood-cell growth- and differentiation-inducing proteins has been shown in culture and in the body. They can, therefore, be clinically useful to correct defects in the development of normal and leukaemic blood cells." @default.
• W2022666564 created "2016-06-24" @default.
• W2022666564 creator A5057501504 @default.
• W2022666564 date "1987-08-21" @default.
• W2022666564 modified "2023-10-12" @default.
• W2022666564 title "The Wellcome Foundation Lecture, 1986 - The molecular regulators of normal and leukaemic blood cells" @default.
• W2022666564 cites W1588060236 @default.
• W2022666564 cites W166477881 @default.
• W2022666564 cites W1891238929 @default.
• W2022666564 cites W1964600284 @default.
• W2022666564 cites W1964717161 @default.
• W2022666564 cites W1964846497 @default.
• W2022666564 cites W1966730043 @default.
• W2022666564 cites W1967157525 @default.
• W2022666564 cites W1968028322 @default.
• W2022666564 cites W1969659046 @default.
• W2022666564 cites W1971724505 @default.
• W2022666564 cites W1971869828 @default.
• W2022666564 cites W1974220772 @default.
• W2022666564 cites W1976566529 @default.
• W2022666564 cites W1980561488 @default.
• W2022666564 cites W1981589031 @default.
• W2022666564 cites W1981712014 @default.
• W2022666564 cites W1982020713 @default.
• W2022666564 cites W1982657915 @default.
• W2022666564 cites W1983816528 @default.
• W2022666564 cites W1984646339 @default.
• W2022666564 cites W1988088718 @default.
• W2022666564 cites W1988096912 @default.
• W2022666564 cites W1993717700 @default.
• W2022666564 cites W1994005628 @default.
• W2022666564 cites W1994204734 @default.
• W2022666564 cites W1994716946 @default.
• W2022666564 cites W1995802882 @default.
• W2022666564 cites W1997844178 @default.
• W2022666564 cites W1998456494 @default.
• W2022666564 cites W1999243294 @default.
• W2022666564 cites W2002680426 @default.
• W2022666564 cites W2003654984 @default.
• W2022666564 cites W2006907494 @default.
• W2022666564 cites W2007960302 @default.
• W2022666564 cites W2008027444 @default.
• W2022666564 cites W2009141646 @default.
• W2022666564 cites W2011052042 @default.
• W2022666564 cites W2011093832 @default.
• W2022666564 cites W2016568386 @default.
• W2022666564 cites W2017060505 @default.
• W2022666564 cites W2020181699 @default.
• W2022666564 cites W2021869571 @default.
• W2022666564 cites W2024508570 @default.
• W2022666564 cites W2025302333 @default.
• W2022666564 cites W2025529909 @default.
• W2022666564 cites W2030003326 @default.
• W2022666564 cites W2030810117 @default.
• W2022666564 cites W2031321924 @default.
• W2022666564 cites W2036631709 @default.
• W2022666564 cites W2042310908 @default.
• W2022666564 cites W2042662552 @default.
• W2022666564 cites W2042686811 @default.
• W2022666564 cites W2046428819 @default.
• W2022666564 cites W2046442258 @default.
• W2022666564 cites W2047101291 @default.
• W2022666564 cites W2047985797 @default.
• W2022666564 cites W2048104971 @default.
• W2022666564 cites W2048659444 @default.
• W2022666564 cites W2049944399 @default.
• W2022666564 cites W2050118032 @default.
• W2022666564 cites W2052214958 @default.
• W2022666564 cites W2052881406 @default.
• W2022666564 cites W2053900502 @default.
• W2022666564 cites W2055765936 @default.
• W2022666564 cites W2060943242 @default.
• W2022666564 cites W2063759625 @default.
• W2022666564 cites W2064722960 @default.
• W2022666564 cites W2065521063 @default.
• W2022666564 cites W2069408330 @default.
• W2022666564 cites W2070201938 @default.
• W2022666564 cites W2071713417 @default.
• W2022666564 cites W2073857478 @default.
• W2022666564 cites W2075853330 @default.
• W2022666564 cites W2077627078 @default.
• W2022666564 cites W2078448496 @default.
• W2022666564 cites W2078554949 @default.
• W2022666564 cites W2079489860 @default.
• W2022666564 cites W2081250302 @default.
• W2022666564 cites W2082256831 @default.
• W2022666564 cites W2084359308 @default.
• W2022666564 cites W2088560606 @default.
• W2022666564 cites W2092368843 @default.
• W2022666564 cites W2105559291 @default.
• W2022666564 cites W2110275443 @default.
• W2022666564 cites W2117243657 @default.
• W2022666564 cites W2117403513 @default.
• W2022666564 cites W2161184440 @default.
• W2022666564 cites W2161315957 @default.
• W2022666564 cites W2182453948 @default.
• W2022666564 cites W2190219227 @default.
• W2022666564 cites W2415736433 @default.

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