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- W2022668129 abstract "Abstract The great mass of experimental and clinical data which has accumulated since Huggins' work in 1939 has substantiated his original claim that in all but a very few instances of prostatic carcinoma “significant improvement” occurs in the clinical condition of patients with far advanced prostatic cancer subjected to castration or the administration of estrogens. Castration should be performed initially if the patient cannot be relied upon to take his estrogens, has troublesome mastitis from the estrogens, or if local growth or pain is not significantly improved after a suitable period of estrogen therapy. Our experience suggests that many patients with carcinoma of the prostate have two separate and distinct periods of clinical regression of both the primary lesion and the metastatic deposits. The first occurs with the administration of estrogens and may be brief or prolonged. The second occurs when orchiectomy is performed in an attempt to control the “secondary” reactivation of the malignant process. We have also injected radioactive isotopes into the primary lesion in almost 100 patients, and have performed bilateral adrenalectomy in eight patients and hypophysectomy in two. Recently we have activated bony metastatic lesions which were progressive and then administered intravenous radioactive sodium phosphate with relief of pain and temporary improvement. These latter measures are not a part of this discussion, but are mentioned to show that the final step in the treatment of prostatic malignancy is yet to come." @default.
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- W2022668129 title "Bilateral orchiectomy in the treatment of carcinoma of the prostate" @default.
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