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• W2022668553 abstract "Stroke is a multifactorial disease that may be associated with aberrant DNA methylation profiles. We investigated epigenetic dysregulation for the methylenetetrahydrofolate reductase ( MTHFR ) gene among ischemic stroke patients. Cases and controls were recruited after obtaining signed written informed consents following a screening process against the inclusion/exclusion criteria. Serum vitamin profiles (folate, vitamin B 12 , and homocysteine) were determined using immunoassays. Methylation profiles for CpGs A and B in the MTHFR gene were determined using a bisulfite-pyrosequencing method. Methylation of MTHFR significantly increased the susceptibility risk for ischemic stroke. In particular, CpG A outperformed CpG B in mediating serum folate and vitamin B 12 levels to increase ischemic stroke susceptibility risks by 4.73-fold. However, both CpGs A and B were not associated with serum homocysteine levels or ischemic stroke severity. CpG A is a potential epigenetic marker in mediating serum folate and vitamin B 12 to contribute to ischemic stroke." @default.
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• W2022668553 date "2015-01-01" @default.
• W2022668553 modified "2023-10-12" @default.
• W2022668553 title "A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B₁₂Levels Contributes to the Risk of Ischemic Stroke" @default.
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• W2022668553 doi "https://doi.org/10.1155/2015/167976" @default.
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