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- W2022671981 abstract "We examined the effect of 1‐palmitoyl‐2‐linoleoylglycerol (PLG), PLG hydroxide (PLG‐OH), and PLG hydroperoxide (PLG‐OOH) on the release of superoxide anion from human PMNs monitored by the chemiluminescence generated by the superoxide anion‐sensitive reagent, 2‐methyl‐6‐( p ‐methoxyphenyl)‐3,7‐dihydroimidazo[1,2‐ a ]pyrazin‐3‐one (MCLA). PLG‐OOH at low micromolar concentrations stimulated human PMNs whereas PLG and PLG‐OH did not. 1,3‐Dilinoleoylglycerol hydroperoxide, 1‐palmitoyl‐2‐linoleoylphosphatidylcholine hydroperoxide, and linoleic acid hydroperoxide were much less efficient in stimulating human PMNs than PLG‐OOH. The PKC inhibitors, chelerythrine chloride and staurosporine, inhibited the stimulation of PMNs. Possible pathophysiological role of 1,2‐diacylglycerol hydroperoxides is discussed." @default.
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- W2022671981 date "1997-08-04" @default.
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- W2022671981 title "1,2‐Diacylglycerol hydroperoxides induce the generation and release of superoxide anion from human polymorphonuclear leukocytes" @default.
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- W2022671981 doi "https://doi.org/10.1016/s0014-5793(97)00823-5" @default.
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