FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022672181> ?p ?o ?g. }

• W2022672181 abstract "Hyperhomocysteinemia is an established risk factor for atherosclerosis, thrombosis and other vascular diseases. Homocysteine auto-oxidation is considered to be crucially involved in the pathogenesis of these diseases. However, the question remains to be elucidated whether vitamin deficiency and homocysteine accumulation are causal for disease development or rather comprise a secondary phenomenon. Most diseases accompanied by hyperhomocysteinemia are also associated with ongoing activation of the immune system. In vitro experiments show homocysteine to accumulate in stimulated peripheral blood mononuclear cells. In patients with coronary heart disease, with rheumatoid arthritis and in patients with dementia, an association between cellular immune activation and homocysteine metabolism is found. Homocysteine concentrations not only correlate inversely with folate concentrations, they also show a positive relationship with concentrations of immune activation markers like neopterin. Moreover, in patients with various kinds of dementia, increased concentrations of serum peroxides, homocysteine and neopterin correlate with each other. Studies support a role of immune system activation in the development of hyperhomocysteinemia. Stimulation and proliferation of immune cells may lead to the production of reactive oxygen species that may oxidize antioxidants and oxidation-sensitive B-vitamins. An enhanced demand for antioxidants as well as folate and vitamin B12 may develop, together with hyperhomocysteinemia, despite sufficient dietary intake." @default.
• W2022672181 created "2016-06-24" @default.
• W2022672181 creator A5028165343 @default.
• W2022672181 creator A5051503017 @default.
• W2022672181 creator A5066705591 @default.
• W2022672181 creator A5071476152 @default.
• W2022672181 creator A5071873982 @default.
• W2022672181 creator A5081156604 @default.
• W2022672181 date "2003-01-17" @default.
• W2022672181 modified "2023-09-27" @default.
• W2022672181 title "Hyperhomocysteinemia and Immune Activation" @default.
• W2022672181 cites W1846391066 @default.
• W2022672181 cites W1847805508 @default.
• W2022672181 cites W1963740601 @default.
• W2022672181 cites W1968143482 @default.
• W2022672181 cites W1974630582 @default.
• W2022672181 cites W1980940682 @default.
• W2022672181 cites W1983722372 @default.
• W2022672181 cites W2010761547 @default.
• W2022672181 cites W2015540532 @default.
• W2022672181 cites W2020649932 @default.
• W2022672181 cites W2020821116 @default.
• W2022672181 cites W2027665192 @default.
• W2022672181 cites W2032317904 @default.
• W2022672181 cites W2035065247 @default.
• W2022672181 cites W2048357248 @default.
• W2022672181 cites W2049087791 @default.
• W2022672181 cites W2053130249 @default.
• W2022672181 cites W2054508440 @default.
• W2022672181 cites W2055703366 @default.
• W2022672181 cites W2068054589 @default.
• W2022672181 cites W2071922368 @default.
• W2022672181 cites W2073295417 @default.
• W2022672181 cites W2079217524 @default.
• W2022672181 cites W2159495338 @default.
• W2022672181 cites W2165885906 @default.
• W2022672181 cites W2166920740 @default.
• W2022672181 cites W2170435800 @default.
• W2022672181 cites W2332958520 @default.
• W2022672181 cites W4256578596 @default.
• W2022672181 cites W7172295 @default.
• W2022672181 doi "https://doi.org/10.1515/cclm.2003.221" @default.
• W2022672181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14656023" @default.
• W2022672181 hasPublicationYear "2003" @default.
• W2022672181 type Work @default.
• W2022672181 sameAs 2022672181 @default.
• W2022672181 citedByCount "44" @default.
• W2022672181 countsByYear W20226721812012 @default.
• W2022672181 countsByYear W20226721812013 @default.
• W2022672181 countsByYear W20226721812014 @default.
• W2022672181 countsByYear W20226721812015 @default.
• W2022672181 countsByYear W20226721812016 @default.
• W2022672181 countsByYear W20226721812017 @default.
• W2022672181 countsByYear W20226721812018 @default.
• W2022672181 countsByYear W20226721812019 @default.
• W2022672181 countsByYear W20226721812020 @default.
• W2022672181 countsByYear W20226721812021 @default.
• W2022672181 countsByYear W20226721812022 @default.
• W2022672181 crossrefType "journal-article" @default.
• W2022672181 hasAuthorship W2022672181A5028165343 @default.
• W2022672181 hasAuthorship W2022672181A5051503017 @default.
• W2022672181 hasAuthorship W2022672181A5066705591 @default.
• W2022672181 hasAuthorship W2022672181A5071476152 @default.
• W2022672181 hasAuthorship W2022672181A5071873982 @default.
• W2022672181 hasAuthorship W2022672181A5081156604 @default.
• W2022672181 hasConcept C126322002 @default.
• W2022672181 hasConcept C134018914 @default.
• W2022672181 hasConcept C203014093 @default.
• W2022672181 hasConcept C2776523773 @default.
• W2022672181 hasConcept C2776603314 @default.
• W2022672181 hasConcept C2777090595 @default.
• W2022672181 hasConcept C2779750884 @default.
• W2022672181 hasConcept C2780942790 @default.
• W2022672181 hasConcept C3020471959 @default.
• W2022672181 hasConcept C71924100 @default.
• W2022672181 hasConcept C8891405 @default.
• W2022672181 hasConceptScore W2022672181C126322002 @default.
• W2022672181 hasConceptScore W2022672181C134018914 @default.
• W2022672181 hasConceptScore W2022672181C203014093 @default.
• W2022672181 hasConceptScore W2022672181C2776523773 @default.
• W2022672181 hasConceptScore W2022672181C2776603314 @default.
• W2022672181 hasConceptScore W2022672181C2777090595 @default.
• W2022672181 hasConceptScore W2022672181C2779750884 @default.
• W2022672181 hasConceptScore W2022672181C2780942790 @default.
• W2022672181 hasConceptScore W2022672181C3020471959 @default.
• W2022672181 hasConceptScore W2022672181C71924100 @default.
• W2022672181 hasConceptScore W2022672181C8891405 @default.
• W2022672181 hasIssue "11" @default.
• W2022672181 hasLocation W20226721811 @default.
• W2022672181 hasLocation W20226721812 @default.
• W2022672181 hasOpenAccess W2022672181 @default.
• W2022672181 hasPrimaryLocation W20226721811 @default.
• W2022672181 hasRelatedWork W1590346643 @default.
• W2022672181 hasRelatedWork W1996283706 @default.
• W2022672181 hasRelatedWork W2022672181 @default.
• W2022672181 hasRelatedWork W2048654257 @default.
• W2022672181 hasRelatedWork W2079217524 @default.
• W2022672181 hasRelatedWork W2111586190 @default.
• W2022672181 hasRelatedWork W2154242075 @default.
• W2022672181 hasRelatedWork W2156278372 @default.

• next