Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022673879> ?p ?o ?g. }
- W2022673879 endingPage "97" @default.
- W2022673879 startingPage "81" @default.
- W2022673879 abstract "The monoamine hypothesis has been the prevailing hypothesis of depression over the last several decades. It states that depression is associated with reduced monoamine function. Hence efforts to increase monoamine transmission by inhibiting serotonin (5-HT) and norepinephrine (NE) transporters has been a central theme in depression research since the 1960s. The selective 5-HT reuptake inhibitors (SSRIs) and 5-HT and NE reuptake inhibitors (SNRIs) that have emerged from this line of research are currently first line treatment options for major depressive disorder (MDD). One of the recent trends in antidepressant research has been to refine monoaminergic mechanisms by targeting monoaminergic receptors and additional transporters (e.g. with multimodal drugs and triple re-uptake inhibitors) or by adding atypical antipsychotics to SSRI or SNRI treatment. In addition, several other hypotheses of depression have been brought forward in pre-clinical and clinical research based on biological hallmarks of the disease and efficacy of pharmacological interventions. A central strategy has been to target glutamate receptors (for example, with intravenous infusions of the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine). Other strategies have been based on modulation of cholinergic and γ-aminobutyric acid (GABA)ergic transmission, neuronal plasticity, stress/hypothalamic pituitary adrenal(HPA)-axis, the reward system and neuroinflammation. Here we review the pharmacological profiles of compounds that derived from these strategies and have been recently tested in clinical trials with published results. In addition, we discuss putative treatments for depression that are being investigated at the preclinical level and outline future directions for antidepressant research." @default.
- W2022673879 created "2016-06-24" @default.
- W2022673879 creator A5018662511 @default.
- W2022673879 creator A5084511552 @default.
- W2022673879 creator A5091492982 @default.
- W2022673879 date "2015-05-01" @default.
- W2022673879 modified "2023-10-16" @default.
- W2022673879 title "Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs" @default.
- W2022673879 cites W120655898 @default.
- W2022673879 cites W1490282579 @default.
- W2022673879 cites W1515310007 @default.
- W2022673879 cites W1519701208 @default.
- W2022673879 cites W1546718520 @default.
- W2022673879 cites W1570504112 @default.
- W2022673879 cites W184284683 @default.
- W2022673879 cites W1894568551 @default.
- W2022673879 cites W1914381346 @default.
- W2022673879 cites W1963753958 @default.
- W2022673879 cites W1965879244 @default.
- W2022673879 cites W1965972184 @default.
- W2022673879 cites W1967017538 @default.
- W2022673879 cites W1968758743 @default.
- W2022673879 cites W1970755410 @default.
- W2022673879 cites W1971355892 @default.
- W2022673879 cites W1972396616 @default.
- W2022673879 cites W1972676417 @default.
- W2022673879 cites W1974109816 @default.
- W2022673879 cites W1975566368 @default.
- W2022673879 cites W1976044410 @default.
- W2022673879 cites W1976392245 @default.
- W2022673879 cites W1976582031 @default.
- W2022673879 cites W1977708183 @default.
- W2022673879 cites W1977856078 @default.
- W2022673879 cites W1981097208 @default.
- W2022673879 cites W1981363848 @default.
- W2022673879 cites W1982429100 @default.
- W2022673879 cites W1983176528 @default.
- W2022673879 cites W1984036736 @default.
- W2022673879 cites W1985438873 @default.
- W2022673879 cites W1986777050 @default.
- W2022673879 cites W1987230615 @default.
- W2022673879 cites W1987514922 @default.
- W2022673879 cites W1988262692 @default.
- W2022673879 cites W1988616499 @default.
- W2022673879 cites W1992962221 @default.
- W2022673879 cites W1995461188 @default.
- W2022673879 cites W1997632825 @default.
- W2022673879 cites W1998894503 @default.
- W2022673879 cites W2002176890 @default.
- W2022673879 cites W2002580140 @default.
- W2022673879 cites W2003665363 @default.
- W2022673879 cites W2006117977 @default.
- W2022673879 cites W2006352405 @default.
- W2022673879 cites W2006460397 @default.
- W2022673879 cites W2006781975 @default.
- W2022673879 cites W2009334465 @default.
- W2022673879 cites W2010226712 @default.
- W2022673879 cites W2011355421 @default.
- W2022673879 cites W2011606125 @default.
- W2022673879 cites W2012424074 @default.
- W2022673879 cites W2012655610 @default.
- W2022673879 cites W2013958954 @default.
- W2022673879 cites W2014192652 @default.
- W2022673879 cites W2014236381 @default.
- W2022673879 cites W2014799344 @default.
- W2022673879 cites W2018008180 @default.
- W2022673879 cites W2018809236 @default.
- W2022673879 cites W2018927341 @default.
- W2022673879 cites W2020739757 @default.
- W2022673879 cites W2022994360 @default.
- W2022673879 cites W2023081218 @default.
- W2022673879 cites W2023748980 @default.
- W2022673879 cites W2024942419 @default.
- W2022673879 cites W2024987400 @default.
- W2022673879 cites W2025725983 @default.
- W2022673879 cites W2026977189 @default.
- W2022673879 cites W2028195884 @default.
- W2022673879 cites W2028423021 @default.
- W2022673879 cites W2028679671 @default.
- W2022673879 cites W2029584624 @default.
- W2022673879 cites W2029732660 @default.
- W2022673879 cites W2032055122 @default.
- W2022673879 cites W2034767261 @default.
- W2022673879 cites W2036812642 @default.
- W2022673879 cites W2037409999 @default.
- W2022673879 cites W2038751380 @default.
- W2022673879 cites W2045030807 @default.
- W2022673879 cites W2045406986 @default.
- W2022673879 cites W2045614420 @default.
- W2022673879 cites W2046299939 @default.
- W2022673879 cites W2047397795 @default.
- W2022673879 cites W2048026164 @default.
- W2022673879 cites W2049808835 @default.
- W2022673879 cites W2050291077 @default.
- W2022673879 cites W2050682860 @default.
- W2022673879 cites W2051770438 @default.
- W2022673879 cites W2053472601 @default.
- W2022673879 cites W2053956493 @default.