FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022674528> ?p ?o ?g. }

• W2022674528 endingPage "75" @default.
• W2022674528 startingPage "65" @default.
• W2022674528 abstract "Previously, we found pulmonary gas trapping to be a rapid, simple and objective measure of methacholine-induced airway obstruction in naïve mice. In this study we extended that finding by using methacholine-induced pulmonary gas trapping to differentiate airway responses of ovalbumin-sensitized, ovalbumin-exposed (Positive Control) and ovalbumin-sensitized, sodium chloride-exposed (Negative Control) mice. Additionally, pulmonary gas trapping and enhanced pause were compared following methacholine exposure in sensitized and nonsensitized mice. Finally, we examined by nose-only inhalation the ability of the glucocorticosteroid budesonide and the peroxisome proliferator-activated receptor-γ agonist ciglitazone to modify methacholine-induced airway responses in ovalbumin-sensitized mice. Positive Controls exhibited a 7.8-fold increase in sensitivity and a 2.4-fold enhancement in the maximal airway obstruction to methacholine versus Negative Controls. Following methacholine, individual Positive and Negative Control mouse enhanced pause values overlapped in 9 of 9 studies, whereas individual Positive and Negative Control mouse excised lung gas volume values overlapped in only 1 of 9 studies, and log[excised lung gas volume] correlated (P = 0.023) with in vivo log[enhanced pause] in nonsensitized mice. Finally, budesonide (100.0 or 1000.0 μg/kg) reduced methacholine-mediated airway responses and eosinophils and neutrophils, whereas ciglitazone (1000.0 μg/kg) had no effect on methacholine-induced pulmonary gas trapping, but reduced eosinophils. In conclusion, pulmonary gas trapping is a more reproducible measure of methacholine-mediated airway responses in ovalbumin-sensitized mice than enhanced pause. Also, excised lung gas volume changes can be used to monitor drug interventions like budesonide. Finally, this study highlights the importance of running a positive comparator when examining novel treatments like ciglitazone." @default.
• W2022674528 created "2016-06-24" @default.
• W2022674528 creator A5008386067 @default.
• W2022674528 creator A5041883185 @default.
• W2022674528 creator A5064788120 @default.
• W2022674528 creator A5071007161 @default.
• W2022674528 creator A5071448765 @default.
• W2022674528 date "2008-01-01" @default.
• W2022674528 modified "2023-10-16" @default.
• W2022674528 title "Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: Effect of inhaled budesonide and ciglitazone" @default.
• W2022674528 cites W1807635121 @default.
• W2022674528 cites W1864307347 @default.
• W2022674528 cites W1942109201 @default.
• W2022674528 cites W1965675027 @default.
• W2022674528 cites W1965731027 @default.
• W2022674528 cites W1971254063 @default.
• W2022674528 cites W1978582808 @default.
• W2022674528 cites W1980074639 @default.
• W2022674528 cites W1987921995 @default.
• W2022674528 cites W1993997407 @default.
• W2022674528 cites W1994460379 @default.
• W2022674528 cites W2000498772 @default.
• W2022674528 cites W2008074433 @default.
• W2022674528 cites W2009618593 @default.
• W2022674528 cites W2012269490 @default.
• W2022674528 cites W2016157758 @default.
• W2022674528 cites W2019485286 @default.
• W2022674528 cites W2024732378 @default.
• W2022674528 cites W2024844751 @default.
• W2022674528 cites W2031388659 @default.
• W2022674528 cites W2041162884 @default.
• W2022674528 cites W2041836753 @default.
• W2022674528 cites W2068847178 @default.
• W2022674528 cites W2079751830 @default.
• W2022674528 cites W2113536628 @default.
• W2022674528 cites W2114770406 @default.
• W2022674528 cites W2121804671 @default.
• W2022674528 cites W2126118351 @default.
• W2022674528 cites W2126452444 @default.
• W2022674528 cites W2133342524 @default.
• W2022674528 cites W2136204115 @default.
• W2022674528 cites W2149742688 @default.
• W2022674528 cites W2150230220 @default.
• W2022674528 cites W2151920252 @default.
• W2022674528 cites W2153231621 @default.
• W2022674528 cites W2153657940 @default.
• W2022674528 cites W2155345300 @default.
• W2022674528 cites W2159069967 @default.
• W2022674528 cites W2159638894 @default.
• W2022674528 cites W2160854440 @default.
• W2022674528 cites W2165283316 @default.
• W2022674528 cites W2167691893 @default.
• W2022674528 cites W2265803435 @default.
• W2022674528 cites W2398079669 @default.
• W2022674528 doi "https://doi.org/10.1016/j.ejphar.2007.08.040" @default.
• W2022674528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17900559" @default.
• W2022674528 hasPublicationYear "2008" @default.
• W2022674528 type Work @default.
• W2022674528 sameAs 2022674528 @default.
• W2022674528 citedByCount "3" @default.
• W2022674528 countsByYear W20226745282014 @default.
• W2022674528 countsByYear W20226745282018 @default.
• W2022674528 countsByYear W20226745282022 @default.
• W2022674528 crossrefType "journal-article" @default.
• W2022674528 hasAuthorship W2022674528A5008386067 @default.
• W2022674528 hasAuthorship W2022674528A5041883185 @default.
• W2022674528 hasAuthorship W2022674528A5064788120 @default.
• W2022674528 hasAuthorship W2022674528A5071007161 @default.
• W2022674528 hasAuthorship W2022674528A5071448765 @default.
• W2022674528 hasConcept C105922876 @default.
• W2022674528 hasConcept C126322002 @default.
• W2022674528 hasConcept C185592680 @default.
• W2022674528 hasConcept C203014093 @default.
• W2022674528 hasConcept C2776042228 @default.
• W2022674528 hasConcept C2776136866 @default.
• W2022674528 hasConcept C2776178081 @default.
• W2022674528 hasConcept C2776946954 @default.
• W2022674528 hasConcept C2776954882 @default.
• W2022674528 hasConcept C2777714996 @default.
• W2022674528 hasConcept C2781260171 @default.
• W2022674528 hasConcept C42219234 @default.
• W2022674528 hasConcept C71924100 @default.
• W2022674528 hasConcept C8891405 @default.
• W2022674528 hasConceptScore W2022674528C105922876 @default.
• W2022674528 hasConceptScore W2022674528C126322002 @default.
• W2022674528 hasConceptScore W2022674528C185592680 @default.
• W2022674528 hasConceptScore W2022674528C203014093 @default.
• W2022674528 hasConceptScore W2022674528C2776042228 @default.
• W2022674528 hasConceptScore W2022674528C2776136866 @default.
• W2022674528 hasConceptScore W2022674528C2776178081 @default.
• W2022674528 hasConceptScore W2022674528C2776946954 @default.
• W2022674528 hasConceptScore W2022674528C2776954882 @default.
• W2022674528 hasConceptScore W2022674528C2777714996 @default.
• W2022674528 hasConceptScore W2022674528C2781260171 @default.
• W2022674528 hasConceptScore W2022674528C42219234 @default.
• W2022674528 hasConceptScore W2022674528C71924100 @default.
• W2022674528 hasConceptScore W2022674528C8891405 @default.
• W2022674528 hasIssue "1" @default.

• next