Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022676069> ?p ?o ?g. }
- W2022676069 endingPage "2291" @default.
- W2022676069 startingPage "2283" @default.
- W2022676069 abstract "Compounds able to interfere with amino acid biosynthesis have the potential to inhibit cell growth. In both prokaryotic and eukaryotic microorganisms, unless an ornithine cyclodeaminase is present, the activity of δ1-pyrroline-5-carboxylate (P5C) reductase is mandatory to proline production, and the enzyme inhibition should result in amino acid starvation, blocking in turn protein synthesis. The ability of some substituted derivatives of aminomethylenebisphosphonic acid and its analogues to interfere with the activity of the enzyme from the human pathogen Streptococcus pyogenes was investigated. Several compounds were able to suppress activity in the micromolar range of concentrations, with a mechanism of uncompetitive type with respect to the substrate P5C and non-competitive with respect to the electron donor NAD(P)H. The actual occurrence of enzyme inhibition in vivo was supported by the effects of the most active derivatives upon bacterial growth and free amino acid content." @default.
- W2022676069 created "2016-06-24" @default.
- W2022676069 creator A5011576853 @default.
- W2022676069 creator A5015893701 @default.
- W2022676069 creator A5018336018 @default.
- W2022676069 creator A5035705547 @default.
- W2022676069 creator A5040590261 @default.
- W2022676069 creator A5046603104 @default.
- W2022676069 creator A5047110362 @default.
- W2022676069 creator A5063684833 @default.
- W2022676069 date "2011-07-09" @default.
- W2022676069 modified "2023-09-23" @default.
- W2022676069 title "δ1-Pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo" @default.
- W2022676069 cites W133864078 @default.
- W2022676069 cites W1507483557 @default.
- W2022676069 cites W1964365246 @default.
- W2022676069 cites W1966629013 @default.
- W2022676069 cites W1970367921 @default.
- W2022676069 cites W1970798262 @default.
- W2022676069 cites W1977150791 @default.
- W2022676069 cites W1991641043 @default.
- W2022676069 cites W1997278297 @default.
- W2022676069 cites W2000863036 @default.
- W2022676069 cites W2007628622 @default.
- W2022676069 cites W2008715595 @default.
- W2022676069 cites W2026573534 @default.
- W2022676069 cites W2033799632 @default.
- W2022676069 cites W2041216801 @default.
- W2022676069 cites W2042496213 @default.
- W2022676069 cites W2043917282 @default.
- W2022676069 cites W2056966276 @default.
- W2022676069 cites W2074660845 @default.
- W2022676069 cites W2086208676 @default.
- W2022676069 cites W2088987512 @default.
- W2022676069 cites W2089981034 @default.
- W2022676069 cites W2100892769 @default.
- W2022676069 cites W2104023491 @default.
- W2022676069 cites W2104717964 @default.
- W2022676069 cites W2105680863 @default.
- W2022676069 cites W2125934521 @default.
- W2022676069 cites W2133401524 @default.
- W2022676069 cites W2144192914 @default.
- W2022676069 cites W2144760185 @default.
- W2022676069 cites W2169281758 @default.
- W2022676069 cites W2171044702 @default.
- W2022676069 cites W4238430183 @default.
- W2022676069 cites W4293247451 @default.
- W2022676069 doi "https://doi.org/10.1007/s00726-011-0970-7" @default.
- W2022676069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3836680" @default.
- W2022676069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21744012" @default.
- W2022676069 hasPublicationYear "2011" @default.
- W2022676069 type Work @default.
- W2022676069 sameAs 2022676069 @default.
- W2022676069 citedByCount "18" @default.
- W2022676069 countsByYear W20226760692012 @default.
- W2022676069 countsByYear W20226760692013 @default.
- W2022676069 countsByYear W20226760692014 @default.
- W2022676069 countsByYear W20226760692015 @default.
- W2022676069 countsByYear W20226760692016 @default.
- W2022676069 countsByYear W20226760692017 @default.
- W2022676069 countsByYear W20226760692020 @default.
- W2022676069 countsByYear W20226760692021 @default.
- W2022676069 countsByYear W20226760692022 @default.
- W2022676069 crossrefType "journal-article" @default.
- W2022676069 hasAuthorship W2022676069A5011576853 @default.
- W2022676069 hasAuthorship W2022676069A5015893701 @default.
- W2022676069 hasAuthorship W2022676069A5018336018 @default.
- W2022676069 hasAuthorship W2022676069A5035705547 @default.
- W2022676069 hasAuthorship W2022676069A5040590261 @default.
- W2022676069 hasAuthorship W2022676069A5046603104 @default.
- W2022676069 hasAuthorship W2022676069A5047110362 @default.
- W2022676069 hasAuthorship W2022676069A5063684833 @default.
- W2022676069 hasBestOaLocation W20226760692 @default.
- W2022676069 hasConcept C134651460 @default.
- W2022676069 hasConcept C150757390 @default.
- W2022676069 hasConcept C150903083 @default.
- W2022676069 hasConcept C181199279 @default.
- W2022676069 hasConcept C185592680 @default.
- W2022676069 hasConcept C202751555 @default.
- W2022676069 hasConcept C207001950 @default.
- W2022676069 hasConcept C2776796294 @default.
- W2022676069 hasConcept C2777468819 @default.
- W2022676069 hasConcept C2779306812 @default.
- W2022676069 hasConcept C2779489039 @default.
- W2022676069 hasConcept C2779707156 @default.
- W2022676069 hasConcept C2779815552 @default.
- W2022676069 hasConcept C2781017228 @default.
- W2022676069 hasConcept C28212737 @default.
- W2022676069 hasConcept C515207424 @default.
- W2022676069 hasConcept C523546767 @default.
- W2022676069 hasConcept C54355233 @default.
- W2022676069 hasConcept C553450214 @default.
- W2022676069 hasConcept C55493867 @default.
- W2022676069 hasConcept C75520062 @default.
- W2022676069 hasConcept C86803240 @default.
- W2022676069 hasConceptScore W2022676069C134651460 @default.
- W2022676069 hasConceptScore W2022676069C150757390 @default.
- W2022676069 hasConceptScore W2022676069C150903083 @default.