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- W2022676277 abstract "Significance Mutations of p53 occur in approximately 50% of human cancer. p53 missense mutations exhibit gain-of-function activities. In this study, we discovered a previously unidentified mechanism of mutant p53 gain-of-function in osteosarcoma and mammary tumors. Our data indicate that mutant p53 binds to E26 transformation-specific motifs in the Pla2g16 phospholipase promoter to induce its expression, which leads to more aggressive and metastatic phenotypes. Thus, the study implicates mutant p53 regulation of lipid metabolism in cancer cells to confer its gain-of-function. The study suggests new therapeutic options for patients with mutant p53." @default.
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- W2022676277 date "2014-07-14" @default.
- W2022676277 modified "2023-10-17" @default.
- W2022676277 title "Pla2g16 phospholipase mediates gain-of-function activities of mutant p53" @default.
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- W2022676277 doi "https://doi.org/10.1073/pnas.1404139111" @default.
- W2022676277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4121829" @default.
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