Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022677577> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2022677577 endingPage "297" @default.
- W2022677577 startingPage "295" @default.
- W2022677577 abstract "About 50% of alcoholic patients relapse within 3 months of treatment. Previous studies have suggested that disulfiram may help to prevent such relapse. The aim of our study was to assess the efficacy and safety of long-term disulfiram treatment in alcohol dependence of adolescents. In this double-blind, placebo-controlled study we recruited 26 adolescents, aged 16–19 years, with chronic or episodic alcohol dependence. Patients were allocated treatment randomly with disulfiram (200 mg daily) or placebo for 90 days. Patients were assessed on the day treatment started and on days 30 and 90 by interview, self-report, questionnaire and laboratory screening. Patients were classified as abstinent, relapsing or non-attending. Time to first treatment failure (relapse or non-attendance) was the primary outcome measure. The disulfiram (n = 13) and placebo (n= 13) groups were well matched in terms of baseline demographic and alcohol-related variables. Thirteen disulfiram-treated and 13 placebo-treated patients completed the treatment phase; seven (1 vs. 6) relapsed, five (3 vs. 2) refused to continue treatment, three (1 vs. 2) had concurrent illness and two (1 vs. 1) had adverse side effects. At the end of treatment, seven disulfiram-treated and two placebo-treated patients had been abstinent continuously (p = 0.0063). Mean cumulative abstinence duration was significantly greater in the disulfiram group than in the placebo group [68.5 (SD 37.5) vs. 29.7 (19.0) days; p = 0.012]. Apart from occasional diarrhoea, there was no difference in side effects between groups. In some cases, disulfiram may be an effective and well-tolerated pharmacological adjunct to psychosocial and behavioural treatment programmes for treatment of adolescent alcohol-dependent patients." @default.
- W2022677577 created "2016-06-24" @default.
- W2022677577 creator A5025878691 @default.
- W2022677577 creator A5089282424 @default.
- W2022677577 date "2003-09-01" @default.
- W2022677577 modified "2023-10-11" @default.
- W2022677577 title "Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents" @default.
- W2022677577 cites W140784171 @default.
- W2022677577 cites W1965755830 @default.
- W2022677577 cites W1976126176 @default.
- W2022677577 cites W1985180181 @default.
- W2022677577 cites W2014242672 @default.
- W2022677577 cites W2022650028 @default.
- W2022677577 cites W2050538748 @default.
- W2022677577 cites W2068611457 @default.
- W2022677577 cites W2093559862 @default.
- W2022677577 cites W2104538950 @default.
- W2022677577 cites W2125077339 @default.
- W2022677577 cites W2141778647 @default.
- W2022677577 cites W2150602253 @default.
- W2022677577 cites W2164937642 @default.
- W2022677577 cites W2275832530 @default.
- W2022677577 cites W2501609791 @default.
- W2022677577 doi "https://doi.org/10.1080/0959523031000154436" @default.
- W2022677577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15385223" @default.
- W2022677577 hasPublicationYear "2003" @default.
- W2022677577 type Work @default.
- W2022677577 sameAs 2022677577 @default.
- W2022677577 citedByCount "59" @default.
- W2022677577 countsByYear W20226775772012 @default.
- W2022677577 countsByYear W20226775772013 @default.
- W2022677577 countsByYear W20226775772014 @default.
- W2022677577 countsByYear W20226775772015 @default.
- W2022677577 countsByYear W20226775772016 @default.
- W2022677577 countsByYear W20226775772018 @default.
- W2022677577 countsByYear W20226775772019 @default.
- W2022677577 countsByYear W20226775772020 @default.
- W2022677577 countsByYear W20226775772021 @default.
- W2022677577 countsByYear W20226775772022 @default.
- W2022677577 countsByYear W20226775772023 @default.
- W2022677577 crossrefType "journal-article" @default.
- W2022677577 hasAuthorship W2022677577A5025878691 @default.
- W2022677577 hasAuthorship W2022677577A5089282424 @default.
- W2022677577 hasConcept C118552586 @default.
- W2022677577 hasConcept C126322002 @default.
- W2022677577 hasConcept C142724271 @default.
- W2022677577 hasConcept C185592680 @default.
- W2022677577 hasConcept C197934379 @default.
- W2022677577 hasConcept C204787440 @default.
- W2022677577 hasConcept C27081682 @default.
- W2022677577 hasConcept C2778523461 @default.
- W2022677577 hasConcept C2779436514 @default.
- W2022677577 hasConcept C2780687700 @default.
- W2022677577 hasConcept C2781066024 @default.
- W2022677577 hasConcept C2781089641 @default.
- W2022677577 hasConcept C55493867 @default.
- W2022677577 hasConcept C71924100 @default.
- W2022677577 hasConcept C98274493 @default.
- W2022677577 hasConceptScore W2022677577C118552586 @default.
- W2022677577 hasConceptScore W2022677577C126322002 @default.
- W2022677577 hasConceptScore W2022677577C142724271 @default.
- W2022677577 hasConceptScore W2022677577C185592680 @default.
- W2022677577 hasConceptScore W2022677577C197934379 @default.
- W2022677577 hasConceptScore W2022677577C204787440 @default.
- W2022677577 hasConceptScore W2022677577C27081682 @default.
- W2022677577 hasConceptScore W2022677577C2778523461 @default.
- W2022677577 hasConceptScore W2022677577C2779436514 @default.
- W2022677577 hasConceptScore W2022677577C2780687700 @default.
- W2022677577 hasConceptScore W2022677577C2781066024 @default.
- W2022677577 hasConceptScore W2022677577C2781089641 @default.
- W2022677577 hasConceptScore W2022677577C55493867 @default.
- W2022677577 hasConceptScore W2022677577C71924100 @default.
- W2022677577 hasConceptScore W2022677577C98274493 @default.
- W2022677577 hasIssue "3" @default.
- W2022677577 hasLocation W20226775771 @default.
- W2022677577 hasLocation W20226775772 @default.
- W2022677577 hasOpenAccess W2022677577 @default.
- W2022677577 hasPrimaryLocation W20226775771 @default.
- W2022677577 hasRelatedWork W1986329842 @default.
- W2022677577 hasRelatedWork W2078531620 @default.
- W2022677577 hasRelatedWork W2079399994 @default.
- W2022677577 hasRelatedWork W2144494266 @default.
- W2022677577 hasRelatedWork W2197706699 @default.
- W2022677577 hasRelatedWork W2244080671 @default.
- W2022677577 hasRelatedWork W2334910609 @default.
- W2022677577 hasRelatedWork W3027683458 @default.
- W2022677577 hasRelatedWork W4236852867 @default.
- W2022677577 hasRelatedWork W2155959339 @default.
- W2022677577 hasVolume "22" @default.
- W2022677577 isParatext "false" @default.
- W2022677577 isRetracted "false" @default.
- W2022677577 magId "2022677577" @default.
- W2022677577 workType "article" @default.