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- W2022677758 abstract "There has been a steady rise in the number of patients suffering from Alzheimer's disease (AD) all over the world. Alzheimer's disease is a genetically heterogeneous neurodegenerative disorder, which is slow in onset but relentless in progress. It is the most common form of onset of adult dementia and attention deficit disorders. Newer drugs are continually introduced into the market with little efficacy. Hence it is worthwhile to explore the utility of traditional medicines in treatment of cognitive disorders. The Indian system of medicine, Ayurveda has been in practice since 5000 years. The main goal of the studies reported here is to investigate the cerebro-protective and memory improving potentials of PHYLLSARONE-2H. β-amyloid, scopolamine, ibotenic acid, CO2and aging induced amnesia, KCN and Carotid artery ligation-induced hypoxia were the experimental models. Basal forebrain lesion induced decrease in cerebral Ach and ChAT activity were assessed, Concentrations of Norepinerphrine, Epinephrine, Dopamine, 5-HT in cerebral cortex, cerebellum, hypothalamus, hippocampus, pons and corpus striatum were measured by HPLC analysis. Neuromorphology, contents of MDA, NO, activities of SOA and CAT were also Measured. Exteroceptive models such as Water maze, Hebb william's maze, Radial arm maze were used to assess acquistion and retention. Neuromorphology, contents of MDA, NO, activities of SOA and CAT were Measured which indicated that PHYLLSARONE-2H significantly protected the experimental animals from hypoxia, stress, amnesia and neurodegeneration. They inhibited KCN and Carotid artery ligation induced hypoxia, reversed amnesia and neurodegeneration induced by β-amyloid, scopolamine, ibotenic acid, CO2and brain aging, produced normalizing action on discrete regions of brain and controlled alterations in neurotransmitter levels due to neurodegeneration. They also decreased ChAT activity in the parietal cortex and inhibited decrease in Ach levels in both parietal and frontal cortex in amnesic rats.Neurohistochemistry revealed that both PHYLLSARONE-2H profoundly reduced the neurodegeneration in the experimental animals. It also improved acquistion and retention capacities of the animals. PHYLLSARONE-2H, profoundly reduced the neurodegeneration, improved learning and memory in the experimental animals. Hence PHYLLSARONE-2H can be of beneficial in the treatment of dementia of Alzheimer's type and other neurodegenerative disorders." @default.
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- W2022677758 date "2008-07-01" @default.
- W2022677758 modified "2023-09-27" @default.
- W2022677758 title "P4-304: Therapeutic effects of a novel phytochemical formulation phyllsarone: 2H in animal models relevant to Alzheimer's disease" @default.
- W2022677758 doi "https://doi.org/10.1016/j.jalz.2008.05.2374" @default.
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