FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022678326> ?p ?o ?g. }

• W2022678326 endingPage "699" @default.
• W2022678326 startingPage "691" @default.
• W2022678326 abstract "The single-dose pharmacokinetics of oral ciprofloxacin 750 mg were evaluated in six subjects with cystic fibrosis (CF subjects) and six age, sex and approximate weight-matched control subjects (controls). In addition, the effect of concurrently administered oral pancreatic enzyme replacement on the pharmacokinetics of ciprofloxacin was studied in 12 CF subjects. Ciprofloxacin t1/2, VssF, CLF, and CLR in the matched CF subjects averaged 4.5 hours, 2.8 L/kg, 2.73 mL/min/kg and 5.7 mL/min/kg, respectively. Forty-two percent of the ciprofloxacin dose was excreted in the urine (0–48 hours) as the parent compound. No statistically significant differences in these ciprofloxacin pharmacokinetic parameter estimates were observed between CF and control subjects. In three CF subjects and two controls, the urinary excretion of ciprofloxacin and four of its metabolites were similar. In contrast, CF subjects demonstrated a prolonged tmax (2.3 versus 1.3 hours P <.05) though ciprofloxacin Cmax was similar (4.7 versus 3.8 mg/L, NS). The concurrent administration of oral pancreatic enzyme replacement had no effect on the pharmacokinetics of ciprofloxacin. Apparent ciprofloxacin pharmacokinetic parameters in sputum were similar to those observed in serum. Sputum ciprofloxacin concentrations lagged behind serum concentrations but, on average, exceeded serum concentrations for 20 hours of the 24-hour sampling period. These sputum ciprofloxacin concentrations exceeded the reported MIC90 for Pseudomonas aeruginosa for approximately 15 hours. These data suggest an oral ciprofloxacin dose of 750 mg administered q8h to promote accumulation and maintenance of sputum drug concentrations well above pathogen MICs for the majority of a dosing interval in patients with CF." @default.
• W2022678326 created "2016-06-24" @default.
• W2022678326 creator A5009402781 @default.
• W2022678326 creator A5011241944 @default.
• W2022678326 creator A5057749716 @default.
• W2022678326 creator A5061924855 @default.
• W2022678326 creator A5076260458 @default.
• W2022678326 date "1988-08-01" @default.
• W2022678326 modified "2023-10-11" @default.
• W2022678326 title "Lack of Unique Ciprofloxacin Pharmacokinetic Characteristics in Patients with Cystic Fibrosis" @default.
• W2022678326 cites W170657596 @default.
• W2022678326 cites W186641811 @default.
• W2022678326 cites W1966848282 @default.
• W2022678326 cites W1969427484 @default.
• W2022678326 cites W1974843386 @default.
• W2022678326 cites W1981212896 @default.
• W2022678326 cites W1982624023 @default.
• W2022678326 cites W1983876157 @default.
• W2022678326 cites W2004403704 @default.
• W2022678326 cites W2027014550 @default.
• W2022678326 cites W2028566024 @default.
• W2022678326 cites W2030593141 @default.
• W2022678326 cites W2030795178 @default.
• W2022678326 cites W2033213467 @default.
• W2022678326 cites W2033379900 @default.
• W2022678326 cites W2036439754 @default.
• W2022678326 cites W2036526333 @default.
• W2022678326 cites W2057691179 @default.
• W2022678326 cites W2063374918 @default.
• W2022678326 cites W2067469709 @default.
• W2022678326 cites W2076664327 @default.
• W2022678326 cites W2085453211 @default.
• W2022678326 cites W2090000999 @default.
• W2022678326 cites W2094495187 @default.
• W2022678326 cites W2099261044 @default.
• W2022678326 cites W2121416492 @default.
• W2022678326 cites W2138927620 @default.
• W2022678326 cites W2143666148 @default.
• W2022678326 cites W2154281938 @default.
• W2022678326 cites W2165317171 @default.
• W2022678326 cites W2166430098 @default.
• W2022678326 cites W2340525737 @default.
• W2022678326 cites W2502670554 @default.
• W2022678326 cites W4317523487 @default.
• W2022678326 doi "https://doi.org/10.1002/j.1552-4604.1988.tb03202.x" @default.
• W2022678326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3216035" @default.
• W2022678326 hasPublicationYear "1988" @default.
• W2022678326 type Work @default.
• W2022678326 sameAs 2022678326 @default.
• W2022678326 citedByCount "31" @default.
• W2022678326 countsByYear W20226783262012 @default.
• W2022678326 countsByYear W20226783262013 @default.
• W2022678326 countsByYear W20226783262015 @default.
• W2022678326 countsByYear W20226783262018 @default.
• W2022678326 countsByYear W20226783262019 @default.
• W2022678326 countsByYear W20226783262020 @default.
• W2022678326 countsByYear W20226783262021 @default.
• W2022678326 crossrefType "journal-article" @default.
• W2022678326 hasAuthorship W2022678326A5009402781 @default.
• W2022678326 hasAuthorship W2022678326A5011241944 @default.
• W2022678326 hasAuthorship W2022678326A5057749716 @default.
• W2022678326 hasAuthorship W2022678326A5061924855 @default.
• W2022678326 hasAuthorship W2022678326A5076260458 @default.
• W2022678326 hasConcept C10146269 @default.
• W2022678326 hasConcept C112705442 @default.
• W2022678326 hasConcept C126322002 @default.
• W2022678326 hasConcept C142724271 @default.
• W2022678326 hasConcept C22979827 @default.
• W2022678326 hasConcept C2776301714 @default.
• W2022678326 hasConcept C2776938444 @default.
• W2022678326 hasConcept C2777056448 @default.
• W2022678326 hasConcept C2778512257 @default.
• W2022678326 hasConcept C2780026642 @default.
• W2022678326 hasConcept C2781069245 @default.
• W2022678326 hasConcept C3019249092 @default.
• W2022678326 hasConcept C501593827 @default.
• W2022678326 hasConcept C71924100 @default.
• W2022678326 hasConcept C86803240 @default.
• W2022678326 hasConcept C89423630 @default.
• W2022678326 hasConcept C90924648 @default.
• W2022678326 hasConcept C98274493 @default.
• W2022678326 hasConceptScore W2022678326C10146269 @default.
• W2022678326 hasConceptScore W2022678326C112705442 @default.
• W2022678326 hasConceptScore W2022678326C126322002 @default.
• W2022678326 hasConceptScore W2022678326C142724271 @default.
• W2022678326 hasConceptScore W2022678326C22979827 @default.
• W2022678326 hasConceptScore W2022678326C2776301714 @default.
• W2022678326 hasConceptScore W2022678326C2776938444 @default.
• W2022678326 hasConceptScore W2022678326C2777056448 @default.
• W2022678326 hasConceptScore W2022678326C2778512257 @default.
• W2022678326 hasConceptScore W2022678326C2780026642 @default.
• W2022678326 hasConceptScore W2022678326C2781069245 @default.
• W2022678326 hasConceptScore W2022678326C3019249092 @default.
• W2022678326 hasConceptScore W2022678326C501593827 @default.
• W2022678326 hasConceptScore W2022678326C71924100 @default.
• W2022678326 hasConceptScore W2022678326C86803240 @default.
• W2022678326 hasConceptScore W2022678326C89423630 @default.
• W2022678326 hasConceptScore W2022678326C90924648 @default.

• next