FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022678344> ?p ?o ?g. }

• W2022678344 endingPage "589" @default.
• W2022678344 startingPage "582" @default.
• W2022678344 abstract "Ganoderma lucidum (Lingzhi) is traditionally drug, which has been traditionally effective used in the treatment of chronic hepatopathy, hypertension, hyperglycemia and cancer. THP-1 and HL-60 apoptosis induced by active lipids of Ganoderma lucidum spores was quantified by flow cytometry using FITC-conjugated annexin V and PI; MAPK and Akt were measured by Western blot, and caspase-3, -8 and -9 activities were also detected by spectrophotometric assay. Our results showed that active lipids of Ganoderma lucidum spores decreased phosphorylation-ERK1/2 (P-ERK1/2), P-Akt and increased P-JNK1/2, but did not affect expressions of P-p38 MAPK in THP-1 cells. Moreover, treatment of THP-1 cells with active lipids of Ganoderma lucidum spores resulted in activation of caspase-3, -8 and -9. Furthermore, LY294002 (Akt inhibitor) or PD98059 (ERK1/2 inhibitor) significantly enhanced active lipids of Ganoderma lucidum spores-induced apoptosis in THP-1 cells, whereas caspase inhibitors or SP600125 (JNK inhibitor), decreased apoptosis in THP-1 cells. Taken together, our study for the first time suggests that active lipids of Ganoderma lucidum spores is able to enhance apoptosis in THP-1 cells, at least in part, through inhibition of ERK1/2, Akt and activation of JNK1/2 signaling pathways. Moreover, it also triggers caspase-3, -8 and -9 activation mediated apoptotic induction." @default.
• W2022678344 created "2016-06-24" @default.
• W2022678344 creator A5009249209 @default.
• W2022678344 creator A5031813793 @default.
• W2022678344 creator A5044879362 @default.
• W2022678344 creator A5074140059 @default.
• W2022678344 creator A5089489848 @default.
• W2022678344 date "2012-01-01" @default.
• W2022678344 modified "2023-10-01" @default.
• W2022678344 title "Active lipids of Ganoderma lucidum spores-induced apoptosis in human leukemia THP-1 cells via MAPK and PI3K pathways" @default.
• W2022678344 cites W1512072225 @default.
• W2022678344 cites W1571757308 @default.
• W2022678344 cites W1744321256 @default.
• W2022678344 cites W1942214720 @default.
• W2022678344 cites W1975700065 @default.
• W2022678344 cites W1976994092 @default.
• W2022678344 cites W1977871132 @default.
• W2022678344 cites W1982214865 @default.
• W2022678344 cites W1986425474 @default.
• W2022678344 cites W1994880478 @default.
• W2022678344 cites W1996405087 @default.
• W2022678344 cites W2000537144 @default.
• W2022678344 cites W2008376266 @default.
• W2022678344 cites W2009233043 @default.
• W2022678344 cites W2009587884 @default.
• W2022678344 cites W2018069818 @default.
• W2022678344 cites W2034872549 @default.
• W2022678344 cites W2035343958 @default.
• W2022678344 cites W2037235124 @default.
• W2022678344 cites W2042193211 @default.
• W2022678344 cites W2054182074 @default.
• W2022678344 cites W2054605167 @default.
• W2022678344 cites W2056735643 @default.
• W2022678344 cites W2058516486 @default.
• W2022678344 cites W2069798744 @default.
• W2022678344 cites W2082793006 @default.
• W2022678344 cites W2084981004 @default.
• W2022678344 cites W2097996208 @default.
• W2022678344 cites W2126533485 @default.
• W2022678344 cites W2139366028 @default.
• W2022678344 cites W2143944971 @default.
• W2022678344 cites W2155124532 @default.
• W2022678344 cites W2164801366 @default.
• W2022678344 cites W2328028977 @default.
• W2022678344 cites W4293775696 @default.
• W2022678344 doi "https://doi.org/10.1016/j.jep.2011.11.055" @default.
• W2022678344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22172327" @default.
• W2022678344 hasPublicationYear "2012" @default.
• W2022678344 type Work @default.
• W2022678344 sameAs 2022678344 @default.
• W2022678344 citedByCount "13" @default.
• W2022678344 countsByYear W20226783442012 @default.
• W2022678344 countsByYear W20226783442015 @default.
• W2022678344 countsByYear W20226783442016 @default.
• W2022678344 countsByYear W20226783442017 @default.
• W2022678344 countsByYear W20226783442018 @default.
• W2022678344 countsByYear W20226783442019 @default.
• W2022678344 countsByYear W20226783442023 @default.
• W2022678344 crossrefType "journal-article" @default.
• W2022678344 hasAuthorship W2022678344A5009249209 @default.
• W2022678344 hasAuthorship W2022678344A5031813793 @default.
• W2022678344 hasAuthorship W2022678344A5044879362 @default.
• W2022678344 hasAuthorship W2022678344A5074140059 @default.
• W2022678344 hasAuthorship W2022678344A5089489848 @default.
• W2022678344 hasConcept C185592680 @default.
• W2022678344 hasConcept C190283241 @default.
• W2022678344 hasConcept C204258353 @default.
• W2022678344 hasConcept C2776618520 @default.
• W2022678344 hasConcept C2776912716 @default.
• W2022678344 hasConcept C2992468417 @default.
• W2022678344 hasConcept C51551487 @default.
• W2022678344 hasConcept C54355233 @default.
• W2022678344 hasConcept C55493867 @default.
• W2022678344 hasConcept C556039675 @default.
• W2022678344 hasConcept C57074206 @default.
• W2022678344 hasConcept C62478195 @default.
• W2022678344 hasConcept C71924100 @default.
• W2022678344 hasConcept C75217442 @default.
• W2022678344 hasConcept C81885089 @default.
• W2022678344 hasConcept C86554907 @default.
• W2022678344 hasConcept C86803240 @default.
• W2022678344 hasConcept C88634738 @default.
• W2022678344 hasConceptScore W2022678344C185592680 @default.
• W2022678344 hasConceptScore W2022678344C190283241 @default.
• W2022678344 hasConceptScore W2022678344C204258353 @default.
• W2022678344 hasConceptScore W2022678344C2776618520 @default.
• W2022678344 hasConceptScore W2022678344C2776912716 @default.
• W2022678344 hasConceptScore W2022678344C2992468417 @default.
• W2022678344 hasConceptScore W2022678344C51551487 @default.
• W2022678344 hasConceptScore W2022678344C54355233 @default.
• W2022678344 hasConceptScore W2022678344C55493867 @default.
• W2022678344 hasConceptScore W2022678344C556039675 @default.
• W2022678344 hasConceptScore W2022678344C57074206 @default.
• W2022678344 hasConceptScore W2022678344C62478195 @default.
• W2022678344 hasConceptScore W2022678344C71924100 @default.
• W2022678344 hasConceptScore W2022678344C75217442 @default.
• W2022678344 hasConceptScore W2022678344C81885089 @default.
• W2022678344 hasConceptScore W2022678344C86554907 @default.

• next