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- W2022678745 abstract "The interaural time difference (ITD) is the primary cue for sound localization; yet many basic questions about the biophysical mechanisms remain. In the mammalian auditory system, neurons in the medial superior olive (MSO) are tuned to ITD as well as frequency. In this study, the effects of key parameters in MSO models, such as the membrane time constants and the number and strength of synaptic inputs on ITD sensitivity to pure tones, were explored with particular attention to the best-frequency dependence of these parameters. Results show that ITD tuning is dependent on neuron membrane characteristics (i.e., the shape and time constant of the membrane response), on the strength of individual synaptic inputs, and on stimulus properties such as frequency and intensity. Models with slow response times and weak synaptic inputs show good ITD sensitivity for low-frequency tones, whereas models with fast response times and strong synaptic inputs exhibit good ITD tuning for high-frequency tones. This dependence of ITD sensitivity on membrane properties in the model suggests that parameters important for ITD tuning depend on the best frequency of the neurons, in contrast to the view that the binaural mechanism is homogeneous along the tonotopic axis." @default.
- W2022678745 created "2016-06-24" @default.
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- W2022678745 date "2010-03-01" @default.
- W2022678745 modified "2023-09-26" @default.
- W2022678745 title "Tonotopic gradients in neural interaural time difference processing: A modeling study of the medial superior olive." @default.
- W2022678745 doi "https://doi.org/10.1121/1.3385142" @default.
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