FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022678865> ?p ?o ?g. }

• W2022678865 endingPage "13468" @default.
• W2022678865 startingPage "13468" @default.
• W2022678865 abstract "A detailed knowledge of the capsid assembly pathways of viruses from their coat protein building blocks is required to devise novel therapeutic strategies to inhibit such assembly. In the quest for understanding how assembly of single-stranded RNA viruses is achieved at the molecular level, HDX-MS has been used to locate regions of a coat protein dimer that exhibit conformational/dynamical changes, and hence changes in their HDX kinetics, upon binding to a genomic RNA stem-loop known to trigger assembly initiation. The HDX-MS data highlight specific areas within the coat protein dimer that alter their exchange kinetics in the presence of the RNA. These include the known RNA-binding sites, β-strands E and G, which have a lower susceptibility to HDX when ligand-bound, as may have been expected. In contrast, several exposed regions are unaffected by ligand binding. Significantly in this example, the loop between β-strands F and G exhibits reduced HDX propensity when the RNA is bound, consistent with previous inferences from NMR and normal mode analysis that suggested a local conformational change at this loop induced by dynamic allostery. These results demonstrate the potential utility of HDX to probe conformational and dynamical changes within non-covalently bound protein–ligand complexes which are of widespread importance in many biomolecular systems." @default.
• W2022678865 created "2016-06-24" @default.
• W2022678865 creator A5012624193 @default.
• W2022678865 creator A5012659242 @default.
• W2022678865 creator A5038102009 @default.
• W2022678865 creator A5052008920 @default.
• W2022678865 creator A5073277649 @default.
• W2022678865 creator A5089380565 @default.
• W2022678865 date "2010-01-01" @default.
• W2022678865 modified "2023-10-17" @default.
• W2022678865 title "RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry" @default.
• W2022678865 cites W1963600084 @default.
• W2022678865 cites W1998266346 @default.
• W2022678865 cites W2003896402 @default.
• W2022678865 cites W2004114526 @default.
• W2022678865 cites W2008818819 @default.
• W2022678865 cites W2012697441 @default.
• W2022678865 cites W2019303898 @default.
• W2022678865 cites W2027864165 @default.
• W2022678865 cites W2042223001 @default.
• W2022678865 cites W2062617571 @default.
• W2022678865 cites W2063811186 @default.
• W2022678865 cites W2073474141 @default.
• W2022678865 cites W2078053008 @default.
• W2022678865 cites W2078507839 @default.
• W2022678865 cites W2083897259 @default.
• W2022678865 cites W2086100460 @default.
• W2022678865 cites W2094225182 @default.
• W2022678865 cites W2114320763 @default.
• W2022678865 cites W2115530019 @default.
• W2022678865 cites W2119134320 @default.
• W2022678865 cites W2126251028 @default.
• W2022678865 cites W2146963696 @default.
• W2022678865 cites W2170979586 @default.
• W2022678865 cites W2985636467 @default.
• W2022678865 doi "https://doi.org/10.1039/c0cp00817f" @default.
• W2022678865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4782220" @default.
• W2022678865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20877857" @default.
• W2022678865 hasPublicationYear "2010" @default.
• W2022678865 type Work @default.
• W2022678865 sameAs 2022678865 @default.
• W2022678865 citedByCount "18" @default.
• W2022678865 countsByYear W20226788652012 @default.
• W2022678865 countsByYear W20226788652013 @default.
• W2022678865 countsByYear W20226788652014 @default.
• W2022678865 countsByYear W20226788652015 @default.
• W2022678865 countsByYear W20226788652016 @default.
• W2022678865 countsByYear W20226788652019 @default.
• W2022678865 countsByYear W20226788652020 @default.
• W2022678865 countsByYear W20226788652023 @default.
• W2022678865 crossrefType "journal-article" @default.
• W2022678865 hasAuthorship W2022678865A5012624193 @default.
• W2022678865 hasAuthorship W2022678865A5012659242 @default.
• W2022678865 hasAuthorship W2022678865A5038102009 @default.
• W2022678865 hasAuthorship W2022678865A5052008920 @default.
• W2022678865 hasAuthorship W2022678865A5073277649 @default.
• W2022678865 hasAuthorship W2022678865A5089380565 @default.
• W2022678865 hasBestOaLocation W20226788652 @default.
• W2022678865 hasConcept C104317684 @default.
• W2022678865 hasConcept C116569031 @default.
• W2022678865 hasConcept C12554922 @default.
• W2022678865 hasConcept C162356407 @default.
• W2022678865 hasConcept C167569220 @default.
• W2022678865 hasConcept C170493617 @default.
• W2022678865 hasConcept C178790620 @default.
• W2022678865 hasConcept C185592680 @default.
• W2022678865 hasConcept C191120209 @default.
• W2022678865 hasConcept C202878990 @default.
• W2022678865 hasConcept C2777339483 @default.
• W2022678865 hasConcept C2779546866 @default.
• W2022678865 hasConcept C43617362 @default.
• W2022678865 hasConcept C55493867 @default.
• W2022678865 hasConcept C67705224 @default.
• W2022678865 hasConcept C8010536 @default.
• W2022678865 hasConcept C86803240 @default.
• W2022678865 hasConceptScore W2022678865C104317684 @default.
• W2022678865 hasConceptScore W2022678865C116569031 @default.
• W2022678865 hasConceptScore W2022678865C12554922 @default.
• W2022678865 hasConceptScore W2022678865C162356407 @default.
• W2022678865 hasConceptScore W2022678865C167569220 @default.
• W2022678865 hasConceptScore W2022678865C170493617 @default.
• W2022678865 hasConceptScore W2022678865C178790620 @default.
• W2022678865 hasConceptScore W2022678865C185592680 @default.
• W2022678865 hasConceptScore W2022678865C191120209 @default.
• W2022678865 hasConceptScore W2022678865C202878990 @default.
• W2022678865 hasConceptScore W2022678865C2777339483 @default.
• W2022678865 hasConceptScore W2022678865C2779546866 @default.
• W2022678865 hasConceptScore W2022678865C43617362 @default.
• W2022678865 hasConceptScore W2022678865C55493867 @default.
• W2022678865 hasConceptScore W2022678865C67705224 @default.
• W2022678865 hasConceptScore W2022678865C8010536 @default.
• W2022678865 hasConceptScore W2022678865C86803240 @default.
• W2022678865 hasIssue "41" @default.
• W2022678865 hasLocation W20226788651 @default.
• W2022678865 hasLocation W20226788652 @default.
• W2022678865 hasLocation W20226788653 @default.
• W2022678865 hasLocation W20226788654 @default.
• W2022678865 hasOpenAccess W2022678865 @default.

• next