Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022679581> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2022679581 abstract "Dectin-1 and Mannose Receptor (MR) are carbohydrate polymer receptors on human monocytes and polymorphonucleocytes (PMN); both are involved in host defence against microbial pathogens through recognition of carbohydrate polymers found in abundance in the cell walls of fungal and bacterial pathogens. The carbohydrate polymers beta-glucan and alpha-mannan are ligands for Dectin-1 and MR, respectively, and have been shown to be immunoactive in numerous studies. The nature and diversity of immune cell responses to immunoactive carbohydrate polymers, as well as the structural variety of the polymers themselves, confound efforts to define structure-activity relationships.[1] This report delineates unique compositional and structural characteristics of carbohydrate polymers found in five fungal-derived commercial natural products sold by prescription or as dietary supplements, and relates these to in vitro biological effects on human monocyte and granulocyte phagocytosis activity. Each product analyzed contains carbohydrate polymers in concentrations ranging from 24.7% –94.1% composed primarily of beta-glucan in configurations unique in terms of pyranose diversity and ratio as well as linkage traits. In ex vivo testing of blood from five healthy human donors, these products were shown to promote phagocytic activity in human monocytes and polymorphonucleocytes to differing degrees. Degree of bioactivity for each product is related to carbohydrate concentration and to percent of (1,4)- and (1,3)-glucan. These results contribute to elucidation of beta-glucan structure function relationships, elaborate on surrogate markers of biological activity for use in quality control efforts of manufacturers, and may help to inform product selection for clinical trials assessing immunomodulating activities of beta-glucan containing natural products." @default.
- W2022679581 created "2016-06-24" @default.
- W2022679581 creator A5009873397 @default.
- W2022679581 creator A5011767092 @default.
- W2022679581 creator A5015463246 @default.
- W2022679581 creator A5027949538 @default.
- W2022679581 creator A5031026263 @default.
- W2022679581 creator A5064997582 @default.
- W2022679581 creator A5066085893 @default.
- W2022679581 creator A5089712764 @default.
- W2022679581 date "2008-07-01" @default.
- W2022679581 modified "2023-09-26" @default.
- W2022679581 title "Phagocytic activity is related to total polysaccharide concentration and percent (1,3), (1,4)-glucan in commercial mushroom extracts" @default.
- W2022679581 doi "https://doi.org/10.1055/s-0028-1084093" @default.
- W2022679581 hasPublicationYear "2008" @default.
- W2022679581 type Work @default.
- W2022679581 sameAs 2022679581 @default.
- W2022679581 citedByCount "0" @default.
- W2022679581 crossrefType "journal-article" @default.
- W2022679581 hasAuthorship W2022679581A5009873397 @default.
- W2022679581 hasAuthorship W2022679581A5011767092 @default.
- W2022679581 hasAuthorship W2022679581A5015463246 @default.
- W2022679581 hasAuthorship W2022679581A5027949538 @default.
- W2022679581 hasAuthorship W2022679581A5031026263 @default.
- W2022679581 hasAuthorship W2022679581A5064997582 @default.
- W2022679581 hasAuthorship W2022679581A5066085893 @default.
- W2022679581 hasAuthorship W2022679581A5089712764 @default.
- W2022679581 hasConcept C100817775 @default.
- W2022679581 hasConcept C170493617 @default.
- W2022679581 hasConcept C185592680 @default.
- W2022679581 hasConcept C203014093 @default.
- W2022679581 hasConcept C2776123893 @default.
- W2022679581 hasConcept C2778977261 @default.
- W2022679581 hasConcept C2779719659 @default.
- W2022679581 hasConcept C2779929572 @default.
- W2022679581 hasConcept C55493867 @default.
- W2022679581 hasConcept C86803240 @default.
- W2022679581 hasConcept C8891405 @default.
- W2022679581 hasConcept C89423630 @default.
- W2022679581 hasConceptScore W2022679581C100817775 @default.
- W2022679581 hasConceptScore W2022679581C170493617 @default.
- W2022679581 hasConceptScore W2022679581C185592680 @default.
- W2022679581 hasConceptScore W2022679581C203014093 @default.
- W2022679581 hasConceptScore W2022679581C2776123893 @default.
- W2022679581 hasConceptScore W2022679581C2778977261 @default.
- W2022679581 hasConceptScore W2022679581C2779719659 @default.
- W2022679581 hasConceptScore W2022679581C2779929572 @default.
- W2022679581 hasConceptScore W2022679581C55493867 @default.
- W2022679581 hasConceptScore W2022679581C86803240 @default.
- W2022679581 hasConceptScore W2022679581C8891405 @default.
- W2022679581 hasConceptScore W2022679581C89423630 @default.
- W2022679581 hasIssue "09" @default.
- W2022679581 hasLocation W20226795811 @default.
- W2022679581 hasOpenAccess W2022679581 @default.
- W2022679581 hasPrimaryLocation W20226795811 @default.
- W2022679581 hasRelatedWork W1571598163 @default.
- W2022679581 hasRelatedWork W1979520689 @default.
- W2022679581 hasRelatedWork W2000456140 @default.
- W2022679581 hasRelatedWork W2002444796 @default.
- W2022679581 hasRelatedWork W2008344062 @default.
- W2022679581 hasRelatedWork W2025956213 @default.
- W2022679581 hasRelatedWork W2028003579 @default.
- W2022679581 hasRelatedWork W3090631589 @default.
- W2022679581 hasRelatedWork W654139485 @default.
- W2022679581 hasRelatedWork W2157478613 @default.
- W2022679581 hasVolume "74" @default.
- W2022679581 isParatext "false" @default.
- W2022679581 isRetracted "false" @default.
- W2022679581 magId "2022679581" @default.
- W2022679581 workType "article" @default.