FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022681912> ?p ?o ?g. }

• W2022681912 endingPage "811" @default.
• W2022681912 startingPage "809" @default.
• W2022681912 abstract "CURRENTLY, transplantation is the best treatment for patients with end-stage organ disease. However, organ shortage severely limits the number of patients who can be treated this way and leads to increased mortality on organ waiting lists. On the other hand, appropriate animals are considered limitless alternative organ sources for such patients. Accordingly, intensive research is underway at many centers to overcome the biological barriers which currently stand in the way of organ acceptance between species. Hyperacute rejection is invariably seen after discordant xenotransplantations with immediate vascular reconstruction. Various strategies have been proposed to solve this problem. Apart from the considerable success achieved with transfection of recipient complement regulatory genes to the donor, no satisfactory progress has been made in overcoming or eliminating this type of rejection. Immunologic tolerance induction against nonself tissues is an attractive means of achieving total or partial acceptance of transplanted organs. The best-known attempts regarding tolerance induction have involved the administration of donor-specific antigens (DSA) (ie, donor-specific cells [DSCs] or, rarely, donor-specific cell-free extracts [DCFE] to the recipient through various routes, with or without concomitant immunosuppression. It has been demonstrated that donor-specific transfusion (DST), or the administration of DSA via various routes to the recipient prior to allotransplantations, generally evokes a certain tolerance status and prolongs allograft survival. Similar attempts at DSA administration have been made recently in xenotransplantation models, but, contrary to the outcome in allogenic models, these resulted in increased sensitivity against, not tolerance to, donor organs. As has been demonstrated repeatedly, the response of the immune system varies according to the antigen administration route. The immune response to antigen administered via the portal vein or oral route is less vigorous than that resulting from the systemic venous route. In order to study xenotolerance, we planned to administer either DCFE or DSCs in a discordant xenotransplant combination. This initial study reports the results of guinea pig-specific DCFE administration to recipient rats without any additional pretreatment. We have chosen DCFE because, as has been suggested, this option is free of the undesirable possibility of graft-vs-host disease and is easier to handle and obtain than DSCs." @default.
• W2022681912 created "2016-06-24" @default.
• W2022681912 creator A5014087215 @default.
• W2022681912 creator A5058356256 @default.
• W2022681912 creator A5083671230 @default.
• W2022681912 date "1998-05-01" @default.
• W2022681912 modified "2023-09-27" @default.
• W2022681912 title "Effects of Various Routes of Donor-Specific Antigen Administration on Graft Survival in a Model of Discordant Heart Xenotransplantation" @default.
• W2022681912 cites W1553215445 @default.
• W2022681912 cites W1626276030 @default.
• W2022681912 cites W1965866471 @default.
• W2022681912 cites W1967702267 @default.
• W2022681912 cites W2005547926 @default.
• W2022681912 cites W2006393457 @default.
• W2022681912 cites W2028537846 @default.
• W2022681912 cites W2049898095 @default.
• W2022681912 cites W2059629634 @default.
• W2022681912 cites W2060373504 @default.
• W2022681912 cites W2088763689 @default.
• W2022681912 cites W4313310729 @default.
• W2022681912 doi "https://doi.org/10.1016/s0041-1345(98)00058-x" @default.
• W2022681912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9595108" @default.
• W2022681912 hasPublicationYear "1998" @default.
• W2022681912 type Work @default.
• W2022681912 sameAs 2022681912 @default.
• W2022681912 citedByCount "0" @default.
• W2022681912 crossrefType "journal-article" @default.
• W2022681912 hasAuthorship W2022681912A5014087215 @default.
• W2022681912 hasAuthorship W2022681912A5058356256 @default.
• W2022681912 hasAuthorship W2022681912A5083671230 @default.
• W2022681912 hasConcept C141071460 @default.
• W2022681912 hasConcept C147483822 @default.
• W2022681912 hasConcept C17744445 @default.
• W2022681912 hasConcept C199539241 @default.
• W2022681912 hasConcept C203014093 @default.
• W2022681912 hasConcept C2778442404 @default.
• W2022681912 hasConcept C2778849806 @default.
• W2022681912 hasConcept C2780765947 @default.
• W2022681912 hasConcept C2911091166 @default.
• W2022681912 hasConcept C71924100 @default.
• W2022681912 hasConceptScore W2022681912C141071460 @default.
• W2022681912 hasConceptScore W2022681912C147483822 @default.
• W2022681912 hasConceptScore W2022681912C17744445 @default.
• W2022681912 hasConceptScore W2022681912C199539241 @default.
• W2022681912 hasConceptScore W2022681912C203014093 @default.
• W2022681912 hasConceptScore W2022681912C2778442404 @default.
• W2022681912 hasConceptScore W2022681912C2778849806 @default.
• W2022681912 hasConceptScore W2022681912C2780765947 @default.
• W2022681912 hasConceptScore W2022681912C2911091166 @default.
• W2022681912 hasConceptScore W2022681912C71924100 @default.
• W2022681912 hasIssue "3" @default.
• W2022681912 hasLocation W20226819121 @default.
• W2022681912 hasLocation W20226819122 @default.
• W2022681912 hasOpenAccess W2022681912 @default.
• W2022681912 hasPrimaryLocation W20226819121 @default.
• W2022681912 hasRelatedWork W2015480977 @default.
• W2022681912 hasRelatedWork W2156440486 @default.
• W2022681912 hasRelatedWork W2291026999 @default.
• W2022681912 hasRelatedWork W2365345400 @default.
• W2022681912 hasRelatedWork W2437832493 @default.
• W2022681912 hasRelatedWork W2906993663 @default.
• W2022681912 hasRelatedWork W3085867863 @default.
• W2022681912 hasRelatedWork W4283452363 @default.
• W2022681912 hasRelatedWork W95730889 @default.
• W2022681912 hasRelatedWork W2395053571 @default.
• W2022681912 hasVolume "30" @default.
• W2022681912 isParatext "false" @default.
• W2022681912 isRetracted "false" @default.
• W2022681912 magId "2022681912" @default.
• W2022681912 workType "article" @default.