Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022682389> ?p ?o ?g. }
- W2022682389 endingPage "6374" @default.
- W2022682389 startingPage "6361" @default.
- W2022682389 abstract "The presence of immortal cell populations with an up-regulated telomere maintenance mechanism (TMM) is an almost universal characteristic of cancers, whereas normal somatic cells are unable to prevent proliferation-associated telomere shortening and have a limited proliferative potential. TMMs and related aspects of telomere structure and function therefore appear to be ideal targets for the development of anticancer therapeutics. Such treatments would be targeted to a specific cancer-related molecular abnormality, and also be broad-spectrum in that they would be expected to be potentially applicable to most cancers. However, the telomere biology of normal and malignant human cells is a relatively young research field with large numbers of unanswered questions, so the optimal design of TMM-targeted therapeutic approaches remains unclear. This review outlines the opportunities and challenges presented by telomeres and TMMs for clinical management of cancer. Keywords: Alternative lengthening of telomeres, cancer, diagnosis, prognosis, telomerase, telomeres, therapy." @default.
- W2022682389 created "2016-06-24" @default.
- W2022682389 creator A5022046476 @default.
- W2022682389 date "2014-10-14" @default.
- W2022682389 modified "2023-10-16" @default.
- W2022682389 title "Telomere Maintenance Mechanisms in Cancer: Clinical Implications" @default.
- W2022682389 cites W1223729236 @default.
- W2022682389 cites W1497143641 @default.
- W2022682389 cites W1500304643 @default.
- W2022682389 cites W1514514999 @default.
- W2022682389 cites W1543500873 @default.
- W2022682389 cites W1545080826 @default.
- W2022682389 cites W1547608553 @default.
- W2022682389 cites W1562677361 @default.
- W2022682389 cites W1600373583 @default.
- W2022682389 cites W1751954544 @default.
- W2022682389 cites W1921809757 @default.
- W2022682389 cites W1947454248 @default.
- W2022682389 cites W1966028695 @default.
- W2022682389 cites W1966346464 @default.
- W2022682389 cites W1968875341 @default.
- W2022682389 cites W1971236130 @default.
- W2022682389 cites W1971361148 @default.
- W2022682389 cites W1974556701 @default.
- W2022682389 cites W1977488724 @default.
- W2022682389 cites W1978631361 @default.
- W2022682389 cites W1979590032 @default.
- W2022682389 cites W1979708010 @default.
- W2022682389 cites W1982199027 @default.
- W2022682389 cites W1982280907 @default.
- W2022682389 cites W1983673827 @default.
- W2022682389 cites W1986009297 @default.
- W2022682389 cites W1989300604 @default.
- W2022682389 cites W1991098068 @default.
- W2022682389 cites W1991124252 @default.
- W2022682389 cites W1993198796 @default.
- W2022682389 cites W1998335196 @default.
- W2022682389 cites W1998371493 @default.
- W2022682389 cites W1998760884 @default.
- W2022682389 cites W1998951941 @default.
- W2022682389 cites W1999240181 @default.
- W2022682389 cites W1999626396 @default.
- W2022682389 cites W2000971601 @default.
- W2022682389 cites W2001258600 @default.
- W2022682389 cites W2001828972 @default.
- W2022682389 cites W2002883144 @default.
- W2022682389 cites W2004314923 @default.
- W2022682389 cites W2009448733 @default.
- W2022682389 cites W2009846227 @default.
- W2022682389 cites W2010882280 @default.
- W2022682389 cites W2010947710 @default.
- W2022682389 cites W2013073993 @default.
- W2022682389 cites W2014414194 @default.
- W2022682389 cites W2014482493 @default.
- W2022682389 cites W2017948235 @default.
- W2022682389 cites W2019958076 @default.
- W2022682389 cites W2020329784 @default.
- W2022682389 cites W2021489383 @default.
- W2022682389 cites W2022013301 @default.
- W2022682389 cites W2024462771 @default.
- W2022682389 cites W2026506163 @default.
- W2022682389 cites W2026781445 @default.
- W2022682389 cites W2026851128 @default.
- W2022682389 cites W2028270913 @default.
- W2022682389 cites W2028643362 @default.
- W2022682389 cites W2029964573 @default.
- W2022682389 cites W2030209169 @default.
- W2022682389 cites W2030976397 @default.
- W2022682389 cites W2032407757 @default.
- W2022682389 cites W2033494613 @default.
- W2022682389 cites W2033673317 @default.
- W2022682389 cites W2033993988 @default.
- W2022682389 cites W2034269086 @default.
- W2022682389 cites W2035898058 @default.
- W2022682389 cites W2037146644 @default.
- W2022682389 cites W2039355301 @default.
- W2022682389 cites W2042377388 @default.
- W2022682389 cites W2042395157 @default.
- W2022682389 cites W2042441290 @default.
- W2022682389 cites W2044606083 @default.
- W2022682389 cites W2045702252 @default.
- W2022682389 cites W2046191561 @default.
- W2022682389 cites W2046268297 @default.
- W2022682389 cites W2046461941 @default.
- W2022682389 cites W2047330128 @default.
- W2022682389 cites W2052370215 @default.
- W2022682389 cites W2054461612 @default.
- W2022682389 cites W2055434716 @default.
- W2022682389 cites W2057969865 @default.
- W2022682389 cites W2058286861 @default.
- W2022682389 cites W2060896826 @default.
- W2022682389 cites W2060955969 @default.
- W2022682389 cites W2062955305 @default.
- W2022682389 cites W2062989155 @default.
- W2022682389 cites W2063794672 @default.
- W2022682389 cites W2064507032 @default.
- W2022682389 cites W2066591425 @default.
- W2022682389 cites W2067733484 @default.