FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022682918> ?p ?o ?g. }

• W2022682918 endingPage "1498" @default.
• W2022682918 startingPage "1494" @default.
• W2022682918 abstract "Many actin binding proteins have a modular architecture, and calponin-homology (CH) domains are one such structurally conserved module found in numerous proteins that interact with F-actin. The manner in which CH-domains bind F-actin has been controversial. Using cryo-EM and a single-particle approach to helical reconstruction, we have generated 12-A-resolution maps of F-actin alone and F-actin decorated with a fragment of human fimbrin (L-plastin) containing tandem CH-domains. The high resolution allows an unambiguous fit of the crystal structure of fimbrin into the map. The interaction between fimbrin ABD2 (actin binding domain 2) and F-actin is different from any interaction previously observed or proposed for tandem CH-domain proteins, showing that the structural conservation of the CH-domains does not lead to a conserved mode of interaction with F-actin. Both the stapling of adjacent actin protomers and the additional closure of the nucleotide binding cleft in F-actin when the fimbrin fragment binds may explain how fimbrin can stabilize actin filaments. A mechanism is proposed where ABD1 of fimbrin becomes activated for binding a second actin filament after ABD2 is bound to a first filament, and this can explain how mutations of residues buried in the interface between ABD2 and ABD1 can rescue temperature-sensitive defects in actin." @default.
• W2022682918 created "2016-06-24" @default.
• W2022682918 creator A5014879094 @default.
• W2022682918 creator A5015343365 @default.
• W2022682918 creator A5054885812 @default.
• W2022682918 creator A5061780801 @default.
• W2022682918 creator A5063231310 @default.
• W2022682918 date "2008-02-05" @default.
• W2022682918 modified "2023-10-10" @default.
• W2022682918 title "High-resolution cryo-EM structure of the F-actin–fimbrin/plastin ABD2 complex" @default.
• W2022682918 cites W1921408963 @default.
• W2022682918 cites W1967471059 @default.
• W2022682918 cites W1972945264 @default.
• W2022682918 cites W1989171342 @default.
• W2022682918 cites W2002343966 @default.
• W2022682918 cites W2003078914 @default.
• W2022682918 cites W2006158980 @default.
• W2022682918 cites W2010147661 @default.
• W2022682918 cites W2010590930 @default.
• W2022682918 cites W2011498709 @default.
• W2022682918 cites W2022297521 @default.
• W2022682918 cites W2026064166 @default.
• W2022682918 cites W2033061682 @default.
• W2022682918 cites W2043316605 @default.
• W2022682918 cites W2043664506 @default.
• W2022682918 cites W2045621376 @default.
• W2022682918 cites W2046314964 @default.
• W2022682918 cites W2048982317 @default.
• W2022682918 cites W2053261565 @default.
• W2022682918 cites W2054174721 @default.
• W2022682918 cites W2057644632 @default.
• W2022682918 cites W2061679830 @default.
• W2022682918 cites W2061758631 @default.
• W2022682918 cites W2064412762 @default.
• W2022682918 cites W2067644355 @default.
• W2022682918 cites W2072089764 @default.
• W2022682918 cites W2074570334 @default.
• W2022682918 cites W2074737006 @default.
• W2022682918 cites W2077353456 @default.
• W2022682918 cites W2084233338 @default.
• W2022682918 cites W2084314403 @default.
• W2022682918 cites W2086004883 @default.
• W2022682918 cites W2087649503 @default.
• W2022682918 cites W2090010970 @default.
• W2022682918 cites W2090847463 @default.
• W2022682918 cites W2091846412 @default.
• W2022682918 cites W2112484783 @default.
• W2022682918 cites W2114178648 @default.
• W2022682918 cites W2115423638 @default.
• W2022682918 cites W2120911894 @default.
• W2022682918 cites W2130108891 @default.
• W2022682918 cites W2130900200 @default.
• W2022682918 cites W2132236474 @default.
• W2022682918 cites W2132629607 @default.
• W2022682918 cites W2159778631 @default.
• W2022682918 cites W2161192962 @default.
• W2022682918 doi "https://doi.org/10.1073/pnas.0708667105" @default.
• W2022682918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2234172" @default.
• W2022682918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18234857" @default.
• W2022682918 hasPublicationYear "2008" @default.
• W2022682918 type Work @default.
• W2022682918 sameAs 2022682918 @default.
• W2022682918 citedByCount "105" @default.
• W2022682918 countsByYear W20226829182012 @default.
• W2022682918 countsByYear W20226829182013 @default.
• W2022682918 countsByYear W20226829182014 @default.
• W2022682918 countsByYear W20226829182015 @default.
• W2022682918 countsByYear W20226829182016 @default.
• W2022682918 countsByYear W20226829182017 @default.
• W2022682918 countsByYear W20226829182018 @default.
• W2022682918 countsByYear W20226829182019 @default.
• W2022682918 countsByYear W20226829182020 @default.
• W2022682918 countsByYear W20226829182021 @default.
• W2022682918 countsByYear W20226829182022 @default.
• W2022682918 countsByYear W20226829182023 @default.
• W2022682918 crossrefType "journal-article" @default.
• W2022682918 hasAuthorship W2022682918A5014879094 @default.
• W2022682918 hasAuthorship W2022682918A5015343365 @default.
• W2022682918 hasAuthorship W2022682918A5054885812 @default.
• W2022682918 hasAuthorship W2022682918A5061780801 @default.
• W2022682918 hasAuthorship W2022682918A5063231310 @default.
• W2022682918 hasBestOaLocation W20226829182 @default.
• W2022682918 hasConcept C12554922 @default.
• W2022682918 hasConcept C125705527 @default.
• W2022682918 hasConcept C130861313 @default.
• W2022682918 hasConcept C14228908 @default.
• W2022682918 hasConcept C142669718 @default.
• W2022682918 hasConcept C1491633281 @default.
• W2022682918 hasConcept C185592680 @default.
• W2022682918 hasConcept C2781122658 @default.
• W2022682918 hasConcept C2993400109 @default.
• W2022682918 hasConcept C53195969 @default.
• W2022682918 hasConcept C55493867 @default.
• W2022682918 hasConcept C86803240 @default.
• W2022682918 hasConcept C95444343 @default.
• W2022682918 hasConceptScore W2022682918C12554922 @default.
• W2022682918 hasConceptScore W2022682918C125705527 @default.
• W2022682918 hasConceptScore W2022682918C130861313 @default.

• next