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- W2022683188 abstract "During the early clinical trials, Abraham, Florey and their associates, 1 investigating the various routes of administration of penicillin, tried the oral route and found that the substance was rapidly destroyed by the hydrochloric acid of the stomach. Their attempts to raise the P h of the gastric contents by the use of sodium bicarbonate were not particularly successful. While they failed to obtain adequate concentrations in the blood after administering solutions of penicillin orally, they were able to recover satisfactory antibacterial amounts in the urine and by this means successfully treated a urinary tract infection in a 6 month old infant. They suggested the use of capsules, but after unsuccessful attempts with phenyl salicylate coated vehicles, abandoned this method. Rammelkamp and Keefer 2 corroborated the previous work of Florey and others 1 in demonstrating the inactivation of penicillin by hydrochloric acid. These investigators administered penicillin by the oral, duodenal" @default.
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- W2022683188 date "1945-05-12" @default.
- W2022683188 modified "2023-10-18" @default.
- W2022683188 title "ORAL ADMINISTRATION OF PENICILLIN" @default.
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- W2022683188 doi "https://doi.org/10.1001/jama.1945.02860190019005" @default.
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