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- W2022683487 endingPage "1056" @default.
- W2022683487 startingPage "1039" @default.
- W2022683487 abstract "To examine the functions of the Arf-like protein, Arl1p, in Saccharomyces cerevisiae, a null allele, arl1delta::HIS3, was constructed in two strains. In one background only, loss of ARL1 resulted in temperature-sensitive (ts) growth (suppressed on high-osmolarity media). Allelic variation at the SSD1 locus accounted for differences between strains. Strains lacking ARL1 exhibited several defects in membrane traffic. First, arl1delta strains secreted less protein as measured by TCA-precipitable radioactivity found in the media of [(35)S]-labelled cells. A portion of newly synthesized carboxypeptidase Y (CPY) was secreted rather than correctly targeted to the vacuole. Uptake of the fluid-phase marker, lucifer yellow, was reduced. All these phenotypes were exacerbated in an ssd1 background. The ts phenotype of the arl1deltassd1 strain was suppressed by YPT1, the yeast Rab1a homologue, suggesting that ARL1 and YPT1 have partially overlapping functions. These findings demonstrate that ARL1 encodes a regulator of membrane traffic." @default.
- W2022683487 created "2016-06-24" @default.
- W2022683487 creator A5018767538 @default.
- W2022683487 creator A5024451170 @default.
- W2022683487 creator A5041909415 @default.
- W2022683487 creator A5052211061 @default.
- W2022683487 creator A5054013035 @default.
- W2022683487 creator A5072106446 @default.
- W2022683487 creator A5087110070 @default.
- W2022683487 creator A5088936289 @default.
- W2022683487 date "2002-01-01" @default.
- W2022683487 modified "2023-10-13" @default.
- W2022683487 title "ARL1 and membrane traffic inSaccharomyces cerevisiae" @default.
- W2022683487 cites W1493142885 @default.
- W2022683487 cites W1503746610 @default.
- W2022683487 cites W1504892441 @default.
- W2022683487 cites W1535587662 @default.
- W2022683487 cites W1537356627 @default.
- W2022683487 cites W1577648891 @default.
- W2022683487 cites W158539957 @default.
- W2022683487 cites W1597352920 @default.
- W2022683487 cites W1747506719 @default.
- W2022683487 cites W1756179169 @default.
- W2022683487 cites W1769996142 @default.
- W2022683487 cites W1773057883 @default.
- W2022683487 cites W1798150371 @default.
- W2022683487 cites W1805781434 @default.
- W2022683487 cites W1811811248 @default.
- W2022683487 cites W1880291900 @default.
- W2022683487 cites W1899541567 @default.
- W2022683487 cites W1911091942 @default.
- W2022683487 cites W1932331203 @default.
- W2022683487 cites W1954259260 @default.
- W2022683487 cites W1965889779 @default.
- W2022683487 cites W1968643238 @default.
- W2022683487 cites W1973691380 @default.
- W2022683487 cites W1973749261 @default.
- W2022683487 cites W1973782344 @default.
- W2022683487 cites W1975777484 @default.
- W2022683487 cites W1976731691 @default.
- W2022683487 cites W1979945257 @default.
- W2022683487 cites W1982988172 @default.
- W2022683487 cites W1985700603 @default.
- W2022683487 cites W1986324000 @default.
- W2022683487 cites W1992674867 @default.
- W2022683487 cites W1995645000 @default.
- W2022683487 cites W1996031986 @default.
- W2022683487 cites W1996147548 @default.
- W2022683487 cites W2006165666 @default.
- W2022683487 cites W2008009726 @default.
- W2022683487 cites W2008046589 @default.
- W2022683487 cites W2008597859 @default.
- W2022683487 cites W2015031589 @default.
- W2022683487 cites W2019126938 @default.
- W2022683487 cites W2019348717 @default.
- W2022683487 cites W2020358132 @default.
- W2022683487 cites W2028000816 @default.
- W2022683487 cites W2038454505 @default.
- W2022683487 cites W2039964610 @default.
- W2022683487 cites W2040649045 @default.
- W2022683487 cites W2041044055 @default.
- W2022683487 cites W2046240394 @default.
- W2022683487 cites W2046533896 @default.
- W2022683487 cites W2052562460 @default.
- W2022683487 cites W2063813586 @default.
- W2022683487 cites W2066221480 @default.
- W2022683487 cites W2066791280 @default.
- W2022683487 cites W2072066861 @default.
- W2022683487 cites W2078959581 @default.
- W2022683487 cites W2080408951 @default.
- W2022683487 cites W2081196990 @default.
- W2022683487 cites W2084753912 @default.
- W2022683487 cites W2086815711 @default.
- W2022683487 cites W2088129156 @default.
- W2022683487 cites W2089697430 @default.
- W2022683487 cites W2094503700 @default.
- W2022683487 cites W2098911116 @default.
- W2022683487 cites W2100837269 @default.
- W2022683487 cites W2102131116 @default.
- W2022683487 cites W2103111390 @default.
- W2022683487 cites W2105717034 @default.
- W2022683487 cites W2108053853 @default.
- W2022683487 cites W2111612340 @default.
- W2022683487 cites W2112830343 @default.
- W2022683487 cites W2113853566 @default.
- W2022683487 cites W2113883578 @default.
- W2022683487 cites W2115073295 @default.
- W2022683487 cites W2124330643 @default.
- W2022683487 cites W2132460046 @default.
- W2022683487 cites W2139868649 @default.
- W2022683487 cites W2140292029 @default.
- W2022683487 cites W2145120474 @default.
- W2022683487 cites W2149177779 @default.
- W2022683487 cites W2151702365 @default.
- W2022683487 cites W2163597027 @default.
- W2022683487 cites W2169333620 @default.
- W2022683487 cites W2170298918 @default.
- W2022683487 cites W2170678054 @default.