Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022684732> ?p ?o ?g. }
- W2022684732 endingPage "658" @default.
- W2022684732 startingPage "646" @default.
- W2022684732 abstract "The neuroprotective effects of basic fibroblast growth factor (bFGF) on the long-term survival of axotomized retinal ganglion cells (RGCs) were studied in the frog Rana pipiens. Cell loss was quantified in different regions of the ganglion cell layer using Nissl staining and tetramethylrhodamine dextran amine backfilling. All regions of the retina showed a significant decrease (32–66%) in RGC numbers between 4 and 16 weeks after axotomy. Some cells showed morphological and biochemical signs of apoptosis. A single application of bFGF to the optic nerve stump at the time of axotomy protected many of the cells 6 weeks after the injury, but this effect was lost by 12 weeks. A second application of bFGF, 6 weeks after the injury, rescued many RGCs at 12 weeks. In contrast, single or double injections of bFGF into the eyeball had no effect on RGC survival. Axotomized RGCs were significantly enlarged and elongated after axotomy, and these morphological changes were increased by bFGF treatment. In the normal retina and optic nerve, immunocytochemical staining showed bFGF-like immunoreactivity (-LI) in the pigment epithelial layer, in the outer segments of photoreceptors, and in occasional RGCs. Strong bFGF-LI was present in Müller cells and in optic nerve astrocytes and oligodendrocytes. FGF receptor-LI was present in photoreceptors, outer plexiform layer, retinal ganglion cell axons, and Müller cells. FGF receptor-LI was also observed in optic nerve glia. J. Comp. Neurol. 423:646–658, 2000. © 2000 Wiley-Liss, Inc." @default.
- W2022684732 created "2016-06-24" @default.
- W2022684732 creator A5013860928 @default.
- W2022684732 creator A5037571952 @default.
- W2022684732 creator A5086597169 @default.
- W2022684732 creator A5087681684 @default.
- W2022684732 date "2000-01-01" @default.
- W2022684732 modified "2023-10-16" @default.
- W2022684732 title "Basic fibroblast growth factor applied to the optic nerve after injury increases long-term cell survival in the frog retina" @default.
- W2022684732 cites W1591839575 @default.
- W2022684732 cites W1601004977 @default.
- W2022684732 cites W1826049628 @default.
- W2022684732 cites W1942388090 @default.
- W2022684732 cites W19429020 @default.
- W2022684732 cites W1964629878 @default.
- W2022684732 cites W1967239011 @default.
- W2022684732 cites W1971320724 @default.
- W2022684732 cites W1971931626 @default.
- W2022684732 cites W1971969664 @default.
- W2022684732 cites W1972056157 @default.
- W2022684732 cites W1974697050 @default.
- W2022684732 cites W1980146517 @default.
- W2022684732 cites W1982248825 @default.
- W2022684732 cites W1982784171 @default.
- W2022684732 cites W1986857435 @default.
- W2022684732 cites W2001511366 @default.
- W2022684732 cites W2003632139 @default.
- W2022684732 cites W2007835476 @default.
- W2022684732 cites W2010247968 @default.
- W2022684732 cites W2012439343 @default.
- W2022684732 cites W2020333978 @default.
- W2022684732 cites W2024753181 @default.
- W2022684732 cites W2024884108 @default.
- W2022684732 cites W2025064586 @default.
- W2022684732 cites W2026431513 @default.
- W2022684732 cites W2027724538 @default.
- W2022684732 cites W2028527748 @default.
- W2022684732 cites W2032322421 @default.
- W2022684732 cites W2033705784 @default.
- W2022684732 cites W2034866347 @default.
- W2022684732 cites W2038262878 @default.
- W2022684732 cites W2043522730 @default.
- W2022684732 cites W2047432057 @default.
- W2022684732 cites W2051417917 @default.
- W2022684732 cites W2055164554 @default.
- W2022684732 cites W2060333628 @default.
- W2022684732 cites W2067522949 @default.
- W2022684732 cites W2078264842 @default.
- W2022684732 cites W2083845304 @default.
- W2022684732 cites W2087651921 @default.
- W2022684732 cites W2090852187 @default.
- W2022684732 cites W2091008509 @default.
- W2022684732 cites W2095609662 @default.
- W2022684732 cites W2097955186 @default.
- W2022684732 cites W2114757694 @default.
- W2022684732 cites W2117097628 @default.
- W2022684732 cites W2123823223 @default.
- W2022684732 cites W2127810698 @default.
- W2022684732 cites W2133685524 @default.
- W2022684732 cites W2135406143 @default.
- W2022684732 cites W2143691192 @default.
- W2022684732 cites W2145426294 @default.
- W2022684732 cites W2155907187 @default.
- W2022684732 cites W2156945415 @default.
- W2022684732 cites W2168737191 @default.
- W2022684732 cites W2571295596 @default.
- W2022684732 cites W4323238131 @default.
- W2022684732 doi "https://doi.org/10.1002/1096-9861(20000807)423:4<646::aid-cne9>3.0.co;2-u" @default.
- W2022684732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10880994" @default.
- W2022684732 hasPublicationYear "2000" @default.
- W2022684732 type Work @default.
- W2022684732 sameAs 2022684732 @default.
- W2022684732 citedByCount "43" @default.
- W2022684732 countsByYear W20226847322012 @default.
- W2022684732 countsByYear W20226847322013 @default.
- W2022684732 countsByYear W20226847322015 @default.
- W2022684732 countsByYear W20226847322016 @default.
- W2022684732 countsByYear W20226847322017 @default.
- W2022684732 countsByYear W20226847322018 @default.
- W2022684732 countsByYear W20226847322019 @default.
- W2022684732 countsByYear W20226847322021 @default.
- W2022684732 countsByYear W20226847322023 @default.
- W2022684732 crossrefType "journal-article" @default.
- W2022684732 hasAuthorship W2022684732A5013860928 @default.
- W2022684732 hasAuthorship W2022684732A5037571952 @default.
- W2022684732 hasAuthorship W2022684732A5086597169 @default.
- W2022684732 hasAuthorship W2022684732A5087681684 @default.
- W2022684732 hasConcept C105702510 @default.
- W2022684732 hasConcept C160539049 @default.
- W2022684732 hasConcept C169760540 @default.
- W2022684732 hasConcept C170493617 @default.
- W2022684732 hasConcept C171056886 @default.
- W2022684732 hasConcept C2775960820 @default.
- W2022684732 hasConcept C2777093970 @default.
- W2022684732 hasConcept C2777506830 @default.
- W2022684732 hasConcept C2777587049 @default.
- W2022684732 hasConcept C2777624874 @default.
- W2022684732 hasConcept C2779683492 @default.