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- W2022685000 abstract "Interference in immunoassay caused by endogenous immunoglobulin is a cause of incorrect laboratory results that can drastically affect patient management. Two cases of immunoglobulin interference in serum follicle-stimulating hormone (FSH) assays are presented. These cases illustrate two common mechanisms for false-positive interference in two-site (sandwich) immunoassays. The first case describes a circulating autoimmune FSH immunoglobulin complex (‘macro’-FSH), which has not been previously described for FSH, and the second a cross-linking antibody directed against the assay reagents. Immunoglobulin interference was detected and characterized using a combination of method comparison, immunosubtraction and size exclusion chromatography." @default.
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- W2022685000 date "2010-05-28" @default.
- W2022685000 modified "2023-09-25" @default.
- W2022685000 title "Immunoglobulin interference in serum follicle-stimulating hormone assays: autoimmune and heterophilic antibody interference" @default.
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- W2022685000 doi "https://doi.org/10.1258/acb.2010.010044" @default.
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