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- W2022687118 abstract "Abstract: The metabolism of p-tert.-butyltoluene (TBT) was studied in the rat and guinea pig. Both the methyl and the tert.-butyl group were oxidized to alcohol and carboxylic acid derivatives in these species. The major urinary metabolites in rats were p-tert.-butylbenzoic acid and its alcohol derivative 2-(p-carboxyphenyl)-2-methylpropan-1-ol whereas p-tert.-butylbenzoylglycine was the most prominent metabolite in guinea pig urine. No significant differences in metabolism were found when TBT was given intragastrically or by inhalation. The intragastric administration of 14C-TBT to rats showed that the bulk of the excretion of radioactivity occurred within three days. A recovery of 83% was achieved and the ratio of urinary/faecal radioactivity was roughly 3.5:1." @default.
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- W2022687118 date "2009-03-13" @default.
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- W2022687118 title "Metabolism of p-tert.-Butyltoluene in the Rat and Guinea Pig" @default.
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- W2022687118 doi "https://doi.org/10.1111/j.1600-0773.1983.tb01868.x" @default.
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