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- W2022688738 abstract "CARDIOVASCULAR DISEASES (CVD) and, in particular, coronary heart disease (CHD) remain the leading cause of death and disability in the western world. 1 Elevated plasma low-density lipoprotein cholesterol (LDL-C) and reduced high-density lipoprotein cholesterol (HDL-C) levels are among the most important risk factors for these diseases. 2 Hydroxymethylglutaryl coenzyme A reductase inhibitors (HMG-CoA-RI), bile acid sequestrants, and nicotinic acid are the major classes of drugs identified for the reduction of elevated total and LDL-C levels in the Adult Treatment Panel II Report. 3 Although highly effective, two of these (bile acid sequestrants and nicotinic acid) have substantial side effects and two (bile acid sequestrants and HMG-CoA-RI) have substantial cost. Nicotinic acid has the greatest HDL-raising effect of any agent used to date 4 ; lesser effects have been observed with gemfibrozil 5 and HMG-CoA-RI. 6 Independent benefit on CVD or CHD risk by increasing plasma levels of HDL has not been" @default.
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- W2022688738 date "1994-07-25" @default.
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- W2022688738 title "Nicotinic Acid as a Lipoprotein-Altering Agent" @default.
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- W2022688738 doi "https://doi.org/10.1001/archinte.1994.00420140015002" @default.
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