FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022690356> ?p ?o ?g. }

• W2022690356 endingPage "120" @default.
• W2022690356 startingPage "113" @default.
• W2022690356 abstract "Podophyllum hexandrum, a herb thriving in Himalayas has already been reported to exhibit antitumor and radioprotective properties. Present study was undertaken to unravel the possible mechanism responsible for the cytotoxic and radioprotective properties of REC-2001, a fraction isolated from the rhizome of P. hexandrum using murine peritoneal macrophages and plasmid DNA as model systems. Cell death, levels of intracellular reactive oxygen species (ROS) and apoptosis were studied employing trypan blue exclusion assay, dichlorofluorescein diacetate and DNA fragmentation assay, respectively. Superoxide anions, hydroxyl radicals and DNA damage were estimated following nitroblue tetrazolium, 2-deoxyribose degradation and plasmid DNA relaxation assays, respectively. Pre-irradiation administration of REC-2001 to peritoneal macrophages in the concentration range of 25-200μg/ml significantly reduced radiation induced ROS generation, DNA damage, apoptosis and cell killing in comparison to radiation control group indicating radioprotective potential. Studies with plasmid DNA indicated the ability of REC-2001 to inhibit 20Gy induced single and double strand breaks further supporting the antioxidative potential. However, REC-2001 in a dose-dependent fashion induced cell death, ROS and DNA fragmentation indicating the cytotoxic nature. REC-2001, in presence of 100μM copper sulfate, generated significant amount of hydroxyl radicals and superoxide anions indicating ability to act as a pro-oxidant in presence of metal ions. The superoxide anion generation was found to be sensitive to metal chelators like EDTA and deferoxamine mesylate (DFR). These results suggest that the ability of REC-2001 to act as a pro-oxidant in presence of metal ions and antioxidant in presence of free radicals might be responsible for cytotoxic and radioprotective properties." @default.
• W2022690356 created "2016-06-24" @default.
• W2022690356 creator A5014686890 @default.
• W2022690356 creator A5016782395 @default.
• W2022690356 creator A5022441636 @default.
• W2022690356 creator A5035505017 @default.
• W2022690356 creator A5041601360 @default.
• W2022690356 creator A5073535477 @default.
• W2022690356 creator A5082386396 @default.
• W2022690356 date "2006-07-01" @default.
• W2022690356 modified "2023-09-26" @default.
• W2022690356 title "Cytotoxic and radioprotective effects of Podophyllum hexandrum" @default.
• W2022690356 cites W13193923 @default.
• W2022690356 cites W1541649582 @default.
• W2022690356 cites W1560590968 @default.
• W2022690356 cites W1745634660 @default.
• W2022690356 cites W190583630 @default.
• W2022690356 cites W1964507340 @default.
• W2022690356 cites W1973101427 @default.
• W2022690356 cites W1973993998 @default.
• W2022690356 cites W1975070995 @default.
• W2022690356 cites W1982591694 @default.
• W2022690356 cites W2025551360 @default.
• W2022690356 cites W2038665226 @default.
• W2022690356 cites W2048622327 @default.
• W2022690356 cites W2086753528 @default.
• W2022690356 cites W2093826154 @default.
• W2022690356 cites W2094188966 @default.
• W2022690356 cites W2109672125 @default.
• W2022690356 cites W2112514832 @default.
• W2022690356 cites W2113999888 @default.
• W2022690356 cites W2132499165 @default.
• W2022690356 cites W2135378138 @default.
• W2022690356 cites W2143952085 @default.
• W2022690356 cites W2155122627 @default.
• W2022690356 cites W2313507339 @default.
• W2022690356 cites W4252582034 @default.
• W2022690356 doi "https://doi.org/10.1016/j.etap.2006.01.001" @default.
• W2022690356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21783696" @default.
• W2022690356 hasPublicationYear "2006" @default.
• W2022690356 type Work @default.
• W2022690356 sameAs 2022690356 @default.
• W2022690356 citedByCount "12" @default.
• W2022690356 countsByYear W20226903562013 @default.
• W2022690356 countsByYear W20226903562014 @default.
• W2022690356 countsByYear W20226903562015 @default.
• W2022690356 countsByYear W20226903562016 @default.
• W2022690356 countsByYear W20226903562020 @default.
• W2022690356 countsByYear W20226903562021 @default.
• W2022690356 countsByYear W20226903562022 @default.
• W2022690356 countsByYear W20226903562023 @default.
• W2022690356 crossrefType "journal-article" @default.
• W2022690356 hasAuthorship W2022690356A5014686890 @default.
• W2022690356 hasAuthorship W2022690356A5016782395 @default.
• W2022690356 hasAuthorship W2022690356A5022441636 @default.
• W2022690356 hasAuthorship W2022690356A5035505017 @default.
• W2022690356 hasAuthorship W2022690356A5041601360 @default.
• W2022690356 hasAuthorship W2022690356A5073535477 @default.
• W2022690356 hasAuthorship W2022690356A5082386396 @default.
• W2022690356 hasConcept C139066938 @default.
• W2022690356 hasConcept C143425029 @default.
• W2022690356 hasConcept C153911025 @default.
• W2022690356 hasConcept C181199279 @default.
• W2022690356 hasConcept C185592680 @default.
• W2022690356 hasConcept C18903297 @default.
• W2022690356 hasConcept C190283241 @default.
• W2022690356 hasConcept C191015642 @default.
• W2022690356 hasConcept C2776778087 @default.
• W2022690356 hasConcept C2778143360 @default.
• W2022690356 hasConcept C2778312706 @default.
• W2022690356 hasConcept C2779964046 @default.
• W2022690356 hasConcept C2780070996 @default.
• W2022690356 hasConcept C2780795997 @default.
• W2022690356 hasConcept C31573885 @default.
• W2022690356 hasConcept C43759708 @default.
• W2022690356 hasConcept C48349386 @default.
• W2022690356 hasConcept C552990157 @default.
• W2022690356 hasConcept C55493867 @default.
• W2022690356 hasConcept C71240020 @default.
• W2022690356 hasConcept C86803240 @default.
• W2022690356 hasConceptScore W2022690356C139066938 @default.
• W2022690356 hasConceptScore W2022690356C143425029 @default.
• W2022690356 hasConceptScore W2022690356C153911025 @default.
• W2022690356 hasConceptScore W2022690356C181199279 @default.
• W2022690356 hasConceptScore W2022690356C185592680 @default.
• W2022690356 hasConceptScore W2022690356C18903297 @default.
• W2022690356 hasConceptScore W2022690356C190283241 @default.
• W2022690356 hasConceptScore W2022690356C191015642 @default.
• W2022690356 hasConceptScore W2022690356C2776778087 @default.
• W2022690356 hasConceptScore W2022690356C2778143360 @default.
• W2022690356 hasConceptScore W2022690356C2778312706 @default.
• W2022690356 hasConceptScore W2022690356C2779964046 @default.
• W2022690356 hasConceptScore W2022690356C2780070996 @default.
• W2022690356 hasConceptScore W2022690356C2780795997 @default.
• W2022690356 hasConceptScore W2022690356C31573885 @default.
• W2022690356 hasConceptScore W2022690356C43759708 @default.
• W2022690356 hasConceptScore W2022690356C48349386 @default.
• W2022690356 hasConceptScore W2022690356C552990157 @default.

• next