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- W2022690443 abstract "S234 INTRODUCTION: The bispectral index (BIS) is closely related to the hypnotic effects of anesthetics [1,2]. We hypothesized that BIS is linked to the stages of spontaneous sleep, which is physiological hypnotic phenomenon. To test the hypothesis, we investigated the changes in BIS during spontaneous sleep in healthy volunteers. METHODS: Following institutional approval, eight healthy men were studied. Each volunteer had routine dinner at 19:00 and went to bet in a temperature-controlled (22[degree sign]C) quiet room at 23:00, when the light was turned off. Frontal-temporal BIS monitoring was performed using an Aspect A-1050 EEG monitor from 23:00 to the time of waking up. The volunteers did not take a bath and any drugs including alcohol during the experimental period. The BIS values sampled at 10 minintervals were used for statistical analysis. RESULTS: The BIS before sleep was 96.4 +/- 1.3 (mean +/- SD). Then, the BIS immediately dropped and changes periodically during sleep (Figure 1). The average of BIS was 71.4 +/- 4.8 (mean +/- SD) in the whole recording period. The minimum value of BIS was 37.5 +/- 6.4 (mean +/- SD). When the volunteers woke up, the BIS was 93.4 +/- 3.3 (mean +/- SD). Total sleep time was 444 +/- 91 min (mean +/- SD).Figure 1: BIS during spontaneous sleep in 8 volunteers. Symbols represent individual values of each 10 min.DISCUSSION: It is well known that the depth of sleep varies cyclically. The present study showed that BIS altered periodically during spontaneous sleep. These results suggest that BIS may represent the conscious level in also the physiological condition." @default.
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- W2022690443 date "1998-02-01" @default.
- W2022690443 modified "2023-10-14" @default.
- W2022690443 title "BISPECTRAL INDEX PERIODICALLY CHANGES DURING SPONTANEOUS SLEEP IN MAN" @default.
- W2022690443 doi "https://doi.org/10.1097/00000539-199802001-00232" @default.
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