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- W2022691480 endingPage "473" @default.
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- W2022691480 abstract "Background Cue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that promote voluntary (self-imposed) abstinence. We also determined the effect of the novel metabotropic glutamate receptor 2 positive allosteric modulator, AZD8529, on incubation of methamphetamine craving after forced or voluntary abstinence. Methods We trained rats to self-administer palatable food (6 sessions) and then to self-administer methamphetamine under two conditions: 12 sessions (9 hours/day) or 50 sessions (3 hours/day). We then assessed cue-induced methamphetamine seeking in extinction tests after 1 or 21 abstinence days. Between tests, the rats underwent either forced abstinence (no access to the food- or drug-paired levers) or voluntary abstinence (achieved via a discrete choice procedure between methamphetamine and palatable food; 20 trials per day) for 19 days. We also determined the effect of subcutaneous injections of AZD8529 (20 and 40 mg/kg) on cue-induced methamphetamine seeking 1 day or 21 days after forced or voluntary abstinence. Results Under both training and abstinence conditions, cue-induced methamphetamine seeking in the extinction tests was higher after 21 abstinence days than after 1 day (incubation of methamphetamine craving). AZD8529 decreased cue-induced methamphetamine seeking on day 21 but not day 1 of forced or voluntary abstinence. Conclusions We introduce a novel animal model to study incubation of drug craving and cue-induced drug seeking after prolonged voluntary abstinence, mimicking the human condition of relapse after successful contingency management treatment. Our data suggest that positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention." @default.
- W2022691480 created "2016-06-24" @default.
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- W2022691480 date "2015-10-01" @default.
- W2022691480 modified "2023-10-14" @default.
- W2022691480 title "Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model" @default.
- W2022691480 cites W1605427252 @default.
- W2022691480 cites W1932011703 @default.
- W2022691480 cites W1941428045 @default.
- W2022691480 cites W1967135019 @default.
- W2022691480 cites W1967292256 @default.
- W2022691480 cites W1967562077 @default.
- W2022691480 cites W1968193935 @default.
- W2022691480 cites W1974215173 @default.
- W2022691480 cites W1978686840 @default.
- W2022691480 cites W1980297985 @default.
- W2022691480 cites W1981763442 @default.
- W2022691480 cites W1983801525 @default.
- W2022691480 cites W1986528761 @default.
- W2022691480 cites W1987096743 @default.
- W2022691480 cites W1990355775 @default.
- W2022691480 cites W1991007482 @default.
- W2022691480 cites W1991857327 @default.
- W2022691480 cites W1992208327 @default.
- W2022691480 cites W1996790468 @default.
- W2022691480 cites W1998645186 @default.
- W2022691480 cites W1999494250 @default.
- W2022691480 cites W1999989514 @default.
- W2022691480 cites W2005921391 @default.
- W2022691480 cites W2007202349 @default.
- W2022691480 cites W2012170184 @default.
- W2022691480 cites W2020406157 @default.
- W2022691480 cites W2023643911 @default.
- W2022691480 cites W2026098772 @default.
- W2022691480 cites W2027931582 @default.
- W2022691480 cites W2032488758 @default.
- W2022691480 cites W2033291340 @default.
- W2022691480 cites W2036512797 @default.
- W2022691480 cites W2037711350 @default.
- W2022691480 cites W2038672096 @default.
- W2022691480 cites W2039839260 @default.
- W2022691480 cites W2040140851 @default.
- W2022691480 cites W2047422895 @default.
- W2022691480 cites W2047783720 @default.
- W2022691480 cites W2047831967 @default.
- W2022691480 cites W2052532655 @default.
- W2022691480 cites W2053058520 @default.
- W2022691480 cites W2053414348 @default.
- W2022691480 cites W2056397792 @default.
- W2022691480 cites W2057753838 @default.
- W2022691480 cites W2057787621 @default.
- W2022691480 cites W2059180163 @default.
- W2022691480 cites W2061922039 @default.
- W2022691480 cites W2062332308 @default.
- W2022691480 cites W2064184606 @default.
- W2022691480 cites W2065940220 @default.
- W2022691480 cites W2068098109 @default.
- W2022691480 cites W2070609048 @default.
- W2022691480 cites W2072292207 @default.
- W2022691480 cites W2074494634 @default.
- W2022691480 cites W2078017910 @default.
- W2022691480 cites W2078805296 @default.
- W2022691480 cites W2080189678 @default.
- W2022691480 cites W2080895561 @default.
- W2022691480 cites W2083683504 @default.
- W2022691480 cites W2085477113 @default.
- W2022691480 cites W2086313373 @default.
- W2022691480 cites W2087309661 @default.
- W2022691480 cites W2087657646 @default.
- W2022691480 cites W2089262034 @default.
- W2022691480 cites W2090618383 @default.
- W2022691480 cites W2093157685 @default.
- W2022691480 cites W2102027938 @default.
- W2022691480 cites W2102167851 @default.
- W2022691480 cites W2104303748 @default.
- W2022691480 cites W2107248076 @default.
- W2022691480 cites W2112323466 @default.
- W2022691480 cites W2112643649 @default.
- W2022691480 cites W2114779627 @default.
- W2022691480 cites W2123946759 @default.
- W2022691480 cites W2125007512 @default.
- W2022691480 cites W2128591343 @default.
- W2022691480 cites W2132259245 @default.
- W2022691480 cites W2136550122 @default.
- W2022691480 cites W2147197593 @default.
- W2022691480 cites W2150585994 @default.
- W2022691480 cites W2152377180 @default.
- W2022691480 cites W2154538414 @default.