Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022692023> ?p ?o ?g. }
- W2022692023 endingPage "1976" @default.
- W2022692023 startingPage "1970" @default.
- W2022692023 abstract "The zinc(II)-dependent matrix metalloproteinases (MMPs) are associated with a variety of diseases. Development of inhibitors to modulate MMP activity has been an active area of investigation for therapeutic development. Hydroxypyrones and hydroxythiopyrones are alternative zinc-binding groups (ZBGs) that, when combined with peptidomimetic backbones, comprise a novel class of MMP inhibitors (MMPi). In this report, a series of hydroxypyrone- and hydroxythiopyrone-based MMPi with aryl backbones at the 2-, 5-, and 6-positions of the hydroxypyrone ring have been synthesized. Synthetic routes for developing inhibitors with substituents at two of these positions (so-called double-handed inhibitors) are also explored. The MMP inhibition profiles and structure–activity relationship of synthesized hydroxypyrones and hydroxythiopyrones have been analyzed. The results here show that the ZBG, the position of the backbone on the ZBG, and the nature of the linker between the ZBG and backbone are critical for MMPi activities." @default.
- W2022692023 created "2016-06-24" @default.
- W2022692023 creator A5015838808 @default.
- W2022692023 creator A5028132671 @default.
- W2022692023 creator A5045012711 @default.
- W2022692023 creator A5059560682 @default.
- W2022692023 date "2009-04-01" @default.
- W2022692023 modified "2023-10-18" @default.
- W2022692023 title "Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: Developing a structure–activity relationship" @default.
- W2022692023 cites W126120635 @default.
- W2022692023 cites W1964499725 @default.
- W2022692023 cites W1967687744 @default.
- W2022692023 cites W1974592901 @default.
- W2022692023 cites W1978320672 @default.
- W2022692023 cites W1985014387 @default.
- W2022692023 cites W1996666690 @default.
- W2022692023 cites W1997619284 @default.
- W2022692023 cites W2001937812 @default.
- W2022692023 cites W2006250045 @default.
- W2022692023 cites W2013363167 @default.
- W2022692023 cites W2019772287 @default.
- W2022692023 cites W2022194542 @default.
- W2022692023 cites W2029004298 @default.
- W2022692023 cites W2032108914 @default.
- W2022692023 cites W2047396221 @default.
- W2022692023 cites W2049375854 @default.
- W2022692023 cites W2055758035 @default.
- W2022692023 cites W2059024219 @default.
- W2022692023 cites W2076407107 @default.
- W2022692023 cites W2085912574 @default.
- W2022692023 cites W2098076093 @default.
- W2022692023 cites W2108121893 @default.
- W2022692023 cites W2127178472 @default.
- W2022692023 cites W2136407689 @default.
- W2022692023 cites W2137272233 @default.
- W2022692023 cites W2143013358 @default.
- W2022692023 cites W2150260451 @default.
- W2022692023 cites W2152207101 @default.
- W2022692023 cites W2154576017 @default.
- W2022692023 doi "https://doi.org/10.1016/j.bmcl.2009.02.044" @default.
- W2022692023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2833267" @default.
- W2022692023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19261472" @default.
- W2022692023 hasPublicationYear "2009" @default.
- W2022692023 type Work @default.
- W2022692023 sameAs 2022692023 @default.
- W2022692023 citedByCount "23" @default.
- W2022692023 countsByYear W20226920232012 @default.
- W2022692023 countsByYear W20226920232013 @default.
- W2022692023 countsByYear W20226920232015 @default.
- W2022692023 countsByYear W20226920232016 @default.
- W2022692023 countsByYear W20226920232017 @default.
- W2022692023 countsByYear W20226920232019 @default.
- W2022692023 countsByYear W20226920232020 @default.
- W2022692023 countsByYear W20226920232021 @default.
- W2022692023 countsByYear W20226920232022 @default.
- W2022692023 crossrefType "journal-article" @default.
- W2022692023 hasAuthorship W2022692023A5015838808 @default.
- W2022692023 hasAuthorship W2022692023A5028132671 @default.
- W2022692023 hasAuthorship W2022692023A5045012711 @default.
- W2022692023 hasAuthorship W2022692023A5059560682 @default.
- W2022692023 hasBestOaLocation W20226920232 @default.
- W2022692023 hasConcept C109523444 @default.
- W2022692023 hasConcept C111919701 @default.
- W2022692023 hasConcept C114373084 @default.
- W2022692023 hasConcept C124790011 @default.
- W2022692023 hasConcept C178790620 @default.
- W2022692023 hasConcept C178910836 @default.
- W2022692023 hasConcept C185592680 @default.
- W2022692023 hasConcept C193042331 @default.
- W2022692023 hasConcept C202751555 @default.
- W2022692023 hasConcept C21951064 @default.
- W2022692023 hasConcept C2775958869 @default.
- W2022692023 hasConcept C2779281246 @default.
- W2022692023 hasConcept C2780263894 @default.
- W2022692023 hasConcept C2780557392 @default.
- W2022692023 hasConcept C2781076698 @default.
- W2022692023 hasConcept C41008148 @default.
- W2022692023 hasConcept C535196362 @default.
- W2022692023 hasConcept C55493867 @default.
- W2022692023 hasConcept C71240020 @default.
- W2022692023 hasConceptScore W2022692023C109523444 @default.
- W2022692023 hasConceptScore W2022692023C111919701 @default.
- W2022692023 hasConceptScore W2022692023C114373084 @default.
- W2022692023 hasConceptScore W2022692023C124790011 @default.
- W2022692023 hasConceptScore W2022692023C178790620 @default.
- W2022692023 hasConceptScore W2022692023C178910836 @default.
- W2022692023 hasConceptScore W2022692023C185592680 @default.
- W2022692023 hasConceptScore W2022692023C193042331 @default.
- W2022692023 hasConceptScore W2022692023C202751555 @default.
- W2022692023 hasConceptScore W2022692023C21951064 @default.
- W2022692023 hasConceptScore W2022692023C2775958869 @default.
- W2022692023 hasConceptScore W2022692023C2779281246 @default.
- W2022692023 hasConceptScore W2022692023C2780263894 @default.
- W2022692023 hasConceptScore W2022692023C2780557392 @default.
- W2022692023 hasConceptScore W2022692023C2781076698 @default.
- W2022692023 hasConceptScore W2022692023C41008148 @default.
- W2022692023 hasConceptScore W2022692023C535196362 @default.
- W2022692023 hasConceptScore W2022692023C55493867 @default.