FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022693844> ?p ?o ?g. }

• W2022693844 endingPage "312" @default.
• W2022693844 startingPage "305" @default.
• W2022693844 abstract "Our study elucidates some mechanisms of contractions or relaxations of isolated porcine left anterior descending coronary artery (LAD) induced by two peptides from the honeybee venom, melittin and apamin. Contractions or relaxations were measured on relaxed or precontracted arteries, respectively. Melittin at lower concentrations (0.1-10 microg/ml) induced transient relaxation, and contraction at higher concentrations (>or=7 microg/ml). The removing of the endothelium diminished the melittin-induced relaxation but did not affect the maximal contraction. The inhibition of prostaglandin and nitric oxide (NO) synthesis (by indomethacin and by N-omega-Nitro-l-arginine, respectively) and the use of K(+) channel inhibitors (apamin and charybdotoxin) showed that melittin evoked relaxation via an endothelium-dependent mechanism (NO production), and by activation of charybdotoxin-sensitive K(+) channels of smooth muscle. Apamin alone did not affect contraction or relaxation, but the inhibition of NO and prostanoid production revealed the involvement of apamin-sensitive K(+) channels of smooth muscle in melittin-induced relaxation. Our data show that melittin and apamin could affect contractility of porcine LAD at concentrations similar to those encountered in multiple honeybee stings in humans. Melittin could directly affect contractility of porcine LAD, whereas apamin acts as a modulator of the relaxant response to melittin." @default.
• W2022693844 created "2016-06-24" @default.
• W2022693844 creator A5038675241 @default.
• W2022693844 creator A5038734235 @default.
• W2022693844 creator A5059447113 @default.
• W2022693844 creator A5062632796 @default.
• W2022693844 date "2010-09-01" @default.
• W2022693844 modified "2023-10-18" @default.
• W2022693844 title "Mechanisms of changes in coronary arterial tone induced by bee venom toxins" @default.
• W2022693844 cites W117310571 @default.
• W2022693844 cites W1511858967 @default.
• W2022693844 cites W1529540653 @default.
• W2022693844 cites W1753089048 @default.
• W2022693844 cites W1904956466 @default.
• W2022693844 cites W1968135647 @default.
• W2022693844 cites W1968783833 @default.
• W2022693844 cites W1971839194 @default.
• W2022693844 cites W1974795129 @default.
• W2022693844 cites W1977307193 @default.
• W2022693844 cites W1979106984 @default.
• W2022693844 cites W1985705824 @default.
• W2022693844 cites W2006947460 @default.
• W2022693844 cites W2012012271 @default.
• W2022693844 cites W2012185701 @default.
• W2022693844 cites W2012907151 @default.
• W2022693844 cites W2015222002 @default.
• W2022693844 cites W2018675171 @default.
• W2022693844 cites W2021783313 @default.
• W2022693844 cites W2025408367 @default.
• W2022693844 cites W2044646390 @default.
• W2022693844 cites W2045293221 @default.
• W2022693844 cites W2051328736 @default.
• W2022693844 cites W2064489455 @default.
• W2022693844 cites W2066807657 @default.
• W2022693844 cites W2072725632 @default.
• W2022693844 cites W2075477567 @default.
• W2022693844 cites W2076052556 @default.
• W2022693844 cites W2086907102 @default.
• W2022693844 cites W2088734315 @default.
• W2022693844 cites W2090283944 @default.
• W2022693844 cites W2094562301 @default.
• W2022693844 cites W2108964501 @default.
• W2022693844 cites W2115153703 @default.
• W2022693844 cites W2115563064 @default.
• W2022693844 cites W2131236495 @default.
• W2022693844 cites W2150931388 @default.
• W2022693844 cites W2169182236 @default.
• W2022693844 cites W2169464781 @default.
• W2022693844 cites W2267087189 @default.
• W2022693844 cites W2274474673 @default.
• W2022693844 cites W2277317702 @default.
• W2022693844 cites W2405542103 @default.
• W2022693844 cites W2414177303 @default.
• W2022693844 cites W2417840604 @default.
• W2022693844 cites W50040476 @default.
• W2022693844 cites W8996059 @default.
• W2022693844 doi "https://doi.org/10.1016/j.toxicon.2010.03.010" @default.
• W2022693844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20307563" @default.
• W2022693844 hasPublicationYear "2010" @default.
• W2022693844 type Work @default.
• W2022693844 sameAs 2022693844 @default.
• W2022693844 citedByCount "5" @default.
• W2022693844 countsByYear W20226938442012 @default.
• W2022693844 countsByYear W20226938442013 @default.
• W2022693844 countsByYear W20226938442015 @default.
• W2022693844 crossrefType "journal-article" @default.
• W2022693844 hasAuthorship W2022693844A5038675241 @default.
• W2022693844 hasAuthorship W2022693844A5038734235 @default.
• W2022693844 hasAuthorship W2022693844A5059447113 @default.
• W2022693844 hasAuthorship W2022693844A5062632796 @default.
• W2022693844 hasConcept C120770815 @default.
• W2022693844 hasConcept C12554922 @default.
• W2022693844 hasConcept C126322002 @default.
• W2022693844 hasConcept C134018914 @default.
• W2022693844 hasConcept C163415756 @default.
• W2022693844 hasConcept C185592680 @default.
• W2022693844 hasConcept C2776050358 @default.
• W2022693844 hasConcept C2776919887 @default.
• W2022693844 hasConcept C2778001312 @default.
• W2022693844 hasConcept C2779281246 @default.
• W2022693844 hasConcept C2780419564 @default.
• W2022693844 hasConcept C39133596 @default.
• W2022693844 hasConcept C519581460 @default.
• W2022693844 hasConcept C55493867 @default.
• W2022693844 hasConcept C71924100 @default.
• W2022693844 hasConcept C83743174 @default.
• W2022693844 hasConcept C86803240 @default.
• W2022693844 hasConcept C98274493 @default.
• W2022693844 hasConceptScore W2022693844C120770815 @default.
• W2022693844 hasConceptScore W2022693844C12554922 @default.
• W2022693844 hasConceptScore W2022693844C126322002 @default.
• W2022693844 hasConceptScore W2022693844C134018914 @default.
• W2022693844 hasConceptScore W2022693844C163415756 @default.
• W2022693844 hasConceptScore W2022693844C185592680 @default.
• W2022693844 hasConceptScore W2022693844C2776050358 @default.
• W2022693844 hasConceptScore W2022693844C2776919887 @default.
• W2022693844 hasConceptScore W2022693844C2778001312 @default.
• W2022693844 hasConceptScore W2022693844C2779281246 @default.

• next