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- W2022694857 abstract "Trisomy of chromosome 12 has been frequently described in various neoplasms, particularly in tumors of the female genitourinary tract. Fluorescence in situ hybridization with a centromeric repetitive DNA probe, specific for chromosome 12, was done to detect such cytogenic changes on frozen-tissue sections from 10 cases of ovarian sex cord stromal tumors. The case series was composed by granulosa cell tumors (four cases), fibromas (four cases), thecoma (one case), and Sertoli-Leydig cell tumor (one case). In granulosa cell tumors, the range of trisomy was 12 to 32% and in fibromas 8 to 22%, whereas in the single case of thecoma trisomy was present in 8% and in the Sertoli-Leydig cell tumor in 4% of the nuclei examined. These results represent an additional series of cases of trisomy 12 in ovarian neoplasms, namely, in ovarian sex cord stromal tumors." @default.
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- W2022694857 date "1993-01-01" @default.
- W2022694857 modified "2023-09-24" @default.
- W2022694857 title "Detection of Trisomy 12 on Ovarian Sex Cord Stromal Tumors by Fluorescence In Situ Hybridization" @default.
- W2022694857 doi "https://doi.org/10.1097/00019606-199300020-00015" @default.
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