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- W2022695672 abstract "Recent research suggests that manic-depressive illness is associated with a membrane abnormality which is detectable in peripheral tissues. Using fluorescence spectroscopy, the cellular membrane dynamics of intact erythrocytes and lymphocytes from manic-depressive patients and controls were studied in a double blind fashion. A cross-sectional analysis of membrane dynamics was obtained by using flourescent probes with known affinity for specific regions of cell membranes. This preliminary study demonstrates alterations in the hydrocarbon region of erythrocyte membranes and the cell surface of lymphocytes in patients with manic-depressive illness. These abnormalities appear to be independent of clinical symptomatology and medication. The membrane abnormality demonstrated by flourescence spectroscopy may provide clues to the molecular pathophysiology in manic-depressive illness, as well as a method of diagnosis in presymptomatic patients." @default.
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- W2022695672 title "Membrane biophysical studies of lymphocytes and erythrocytes in manic-depressive illness" @default.
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- W2022695672 doi "https://doi.org/10.1016/0165-0327(82)90008-8" @default.
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