FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022696064> ?p ?o ?g. }

• W2022696064 endingPage "6114" @default.
• W2022696064 startingPage "6106" @default.
• W2022696064 abstract "Abstract A new biomolecular device for investigating the interactions of ligands with constrained DNA quadruplex topologies, using surface plasmon resonance (SPR), is reported. Biomolecular systems containing an intermolecular‐like G‐quadruplex motif 1 (parallel G‐quadruplex conformation), an intramolecular G‐quadruplex 2 , and a duplex DNA 3 have been designed and developed. The method is based on the concept of template‐assembled synthetic G‐quadruplex (TASQ), whereby quadruplex DNA structures are assembled on a template that allows precise control of the parallel G‐quadruplex conformation. Various known G‐quadruplex ligands have been used to investigate the affinities of ligands for intermolecular 1 and intramolecular 2 DNA quadruplexes. As anticipated, ligands displaying a π‐stacking binding mode showed a higher binding affinity for intermolecular‐like G‐quadruplexes 1 , whereas ligands with other binding modes (groove and/or loop binding) showed no significant difference in their binding affinities for the two quadruplexes 1 or 2 . In addition, the present method has also provided information about the selectivity of ligands for G‐quadruplex DNA over the duplex DNA. A numerical parameter, termed the G‐quadruplex binding mode index (G4‐BMI), has been introduced to express the difference in the affinities of ligands for intermolecular G‐quadruplex 1 against intramolecular G‐quadruplex 2 . The G‐quadruplex binding mode index (G4‐BMI) of a ligand is defined as follows: G4‐BMI= K D intra / K D inter , where K D intra is the dissociation constant for intramolecular G‐quadruplex 2 and K D inter is the dissociation constant for intermolecular G‐quadruplex 1 . In summary, the present work has demonstrated that the use of parallel‐constrained quadruplex topology provides more precise information about the binding modes of ligands." @default.
• W2022696064 created "2016-06-24" @default.
• W2022696064 creator A5000847014 @default.
• W2022696064 creator A5015588191 @default.
• W2022696064 creator A5019985028 @default.
• W2022696064 creator A5032063935 @default.
• W2022696064 creator A5059072908 @default.
• W2022696064 creator A5070341309 @default.
• W2022696064 creator A5071622051 @default.
• W2022696064 creator A5072356033 @default.
• W2022696064 creator A5051639564 @default.
• W2022696064 date "2010-05-14" @default.
• W2022696064 modified "2023-10-18" @default.
• W2022696064 title "Template-Assembled Synthetic G-Quadruplex (TASQ): A Useful System for Investigating the Interactions of Ligands with Constrained Quadruplex Topologies" @default.
• W2022696064 cites W1810809543 @default.
• W2022696064 cites W1967361517 @default.
• W2022696064 cites W1968221949 @default.
• W2022696064 cites W1969453135 @default.
• W2022696064 cites W1972969946 @default.
• W2022696064 cites W1976845115 @default.
• W2022696064 cites W1978502771 @default.
• W2022696064 cites W1980382899 @default.
• W2022696064 cites W1980822832 @default.
• W2022696064 cites W1980849347 @default.
• W2022696064 cites W1983168758 @default.
• W2022696064 cites W1983338915 @default.
• W2022696064 cites W1990635146 @default.
• W2022696064 cites W1991590162 @default.
• W2022696064 cites W1996101871 @default.
• W2022696064 cites W1998434054 @default.
• W2022696064 cites W1998919565 @default.
• W2022696064 cites W2000929500 @default.
• W2022696064 cites W2003484228 @default.
• W2022696064 cites W2004833536 @default.
• W2022696064 cites W2013852630 @default.
• W2022696064 cites W2016636515 @default.
• W2022696064 cites W2018104916 @default.
• W2022696064 cites W2018639298 @default.
• W2022696064 cites W2020008177 @default.
• W2022696064 cites W2024462771 @default.
• W2022696064 cites W2025248257 @default.
• W2022696064 cites W2030609351 @default.
• W2022696064 cites W2035502190 @default.
• W2022696064 cites W2037144426 @default.
• W2022696064 cites W2037727453 @default.
• W2022696064 cites W2046295130 @default.
• W2022696064 cites W2049742274 @default.
• W2022696064 cites W2050913592 @default.
• W2022696064 cites W2052370215 @default.
• W2022696064 cites W2053166926 @default.
• W2022696064 cites W2059113563 @default.
• W2022696064 cites W2059871945 @default.
• W2022696064 cites W2060386011 @default.
• W2022696064 cites W2062451058 @default.
• W2022696064 cites W2067184067 @default.
• W2022696064 cites W2073722866 @default.
• W2022696064 cites W2075529035 @default.
• W2022696064 cites W2076335297 @default.
• W2022696064 cites W2076956316 @default.
• W2022696064 cites W2077316773 @default.
• W2022696064 cites W2079204043 @default.
• W2022696064 cites W2080661557 @default.
• W2022696064 cites W2085004169 @default.
• W2022696064 cites W2088456802 @default.
• W2022696064 cites W2089598395 @default.
• W2022696064 cites W2090885487 @default.
• W2022696064 cites W2092324565 @default.
• W2022696064 cites W2092452241 @default.
• W2022696064 cites W2092599205 @default.
• W2022696064 cites W2101616756 @default.
• W2022696064 cites W2105182287 @default.
• W2022696064 cites W2115639078 @default.
• W2022696064 cites W2123525790 @default.
• W2022696064 cites W2141520007 @default.
• W2022696064 cites W2147643191 @default.
• W2022696064 cites W2147909833 @default.
• W2022696064 cites W2148417602 @default.
• W2022696064 cites W2154265691 @default.
• W2022696064 cites W2156104806 @default.
• W2022696064 cites W2158693186 @default.
• W2022696064 cites W2159960424 @default.
• W2022696064 cites W2169745877 @default.
• W2022696064 cites W2171830519 @default.
• W2022696064 cites W2951024110 @default.
• W2022696064 cites W4236397421 @default.
• W2022696064 cites W4237540956 @default.
• W2022696064 cites W4249024724 @default.
• W2022696064 doi "https://doi.org/10.1002/chem.200903456" @default.
• W2022696064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20397247" @default.
• W2022696064 hasPublicationYear "2010" @default.
• W2022696064 type Work @default.
• W2022696064 sameAs 2022696064 @default.
• W2022696064 citedByCount "58" @default.
• W2022696064 countsByYear W20226960642012 @default.
• W2022696064 countsByYear W20226960642013 @default.
• W2022696064 countsByYear W20226960642014 @default.
• W2022696064 countsByYear W20226960642015 @default.
• W2022696064 countsByYear W20226960642016 @default.

• next