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• W2022697156 abstract "Multiple sequence alignment (MSA) of DNA, RNA, and protein sequences is one of the most essential techniques in the fields of molecular biology, computational biology, and bioinformatics. Next-generation sequencing technologies are changing the biology landscape, flooding the databases with massive amounts of raw sequence data. MSA of ever-increasing sequence data sets is becoming a significant bottleneck. In order to realise the promise of MSA for large-scale sequence data sets, it is necessary for existing MSA algorithms to be run in a parallelised fashion with the sequence data distributed over a computing cluster or server farm. Combining MSA algorithms with cloud computing technologies is therefore likely to improve the speed, quality, and capability for MSA to handle large numbers of sequences. In this review, multiple sequence alignments are discussed, with a specific focus on the ClustalW and Clustal Omega algorithms. Cloud computing technologies and concepts are outlined, and the next generation of cloud base MSA algorithms is introduced." @default.
• W2022697156 created "2016-06-24" @default.
• W2022697156 creator A5035931588 @default.
• W2022697156 creator A5081206407 @default.
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• W2022697156 date "2013-08-14" @default.
• W2022697156 modified "2023-10-18" @default.
• W2022697156 title "An Overview of Multiple Sequence Alignments and Cloud Computing in Bioinformatics" @default.
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• W2022697156 doi "https://doi.org/10.1155/2013/615630" @default.
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