FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022697357> ?p ?o ?g. }

• W2022697357 endingPage "386" @default.
• W2022697357 startingPage "376" @default.
• W2022697357 abstract "Oxidative stress results in protein oxidation and is involved in the pathogenesis of lung diseases such as chronic obstructive pulmonary disorder (COPD). Sulfiredoxin-1 (Srx1) catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation. This study examined the mechanism of transcriptional regulation of Srx1 and its possible protective role during oxidative stress associated with COPD. Nrf2, a transcription factor known to influence susceptibility to pulmonary diseases, upregulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs of mice. Disruption of Nrf2 signaling by genetic knockout in mice or RNAi in cells downregulated the expression of Srx1. In silico analysis of the 5'-promoter-flanking region of Srx1 identified multiple antioxidant-response elements (AREs) that are highly conserved. Reporter and chromatin-immunoprecipitation assays demonstrated that ARE1 at -228 is critical for the Nrf2-mediated response. Attenuation of Srx1 expression with RNAi potentiated the toxicity of hydrogen peroxide (H2O2), whereas overexpression of Srx1 protected against H2O2-mediated cell death in vitro. Immunoblot analysis revealed dramatic decreases in Srx1 expression in lungs from patients with COPD relative to nonemphysematous lungs together with a decline in Nrf2 protein. Thus, Srx1, a key Nrf2-regulated gene, contributes to protection against oxidative injury in the lung." @default.
• W2022697357 created "2016-06-24" @default.
• W2022697357 creator A5025811477 @default.
• W2022697357 creator A5044321008 @default.
• W2022697357 creator A5045890628 @default.
• W2022697357 creator A5048650670 @default.
• W2022697357 creator A5054202326 @default.
• W2022697357 creator A5067454062 @default.
• W2022697357 creator A5067971569 @default.
• W2022697357 creator A5072089972 @default.
• W2022697357 creator A5081578838 @default.
• W2022697357 creator A5082803074 @default.
• W2022697357 creator A5082807323 @default.
• W2022697357 date "2009-02-01" @default.
• W2022697357 modified "2023-10-17" @default.
• W2022697357 title "Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs" @default.
• W2022697357 cites W1604748982 @default.
• W2022697357 cites W1967925595 @default.
• W2022697357 cites W1969770714 @default.
• W2022697357 cites W1973191433 @default.
• W2022697357 cites W1976136891 @default.
• W2022697357 cites W1977804319 @default.
• W2022697357 cites W1984454286 @default.
• W2022697357 cites W1985776151 @default.
• W2022697357 cites W1991631628 @default.
• W2022697357 cites W1992673961 @default.
• W2022697357 cites W1993058298 @default.
• W2022697357 cites W2000017694 @default.
• W2022697357 cites W2001051081 @default.
• W2022697357 cites W2002483552 @default.
• W2022697357 cites W2008035030 @default.
• W2022697357 cites W2019940278 @default.
• W2022697357 cites W2022727685 @default.
• W2022697357 cites W2026987279 @default.
• W2022697357 cites W2031679199 @default.
• W2022697357 cites W2038411014 @default.
• W2022697357 cites W2039105541 @default.
• W2022697357 cites W2048650447 @default.
• W2022697357 cites W2049713754 @default.
• W2022697357 cites W2052521727 @default.
• W2022697357 cites W2053401639 @default.
• W2022697357 cites W2079434650 @default.
• W2022697357 cites W2083287953 @default.
• W2022697357 cites W2091421796 @default.
• W2022697357 cites W2092449641 @default.
• W2022697357 cites W2094026727 @default.
• W2022697357 cites W2095835362 @default.
• W2022697357 cites W2098039543 @default.
• W2022697357 cites W2115846243 @default.
• W2022697357 cites W2117560139 @default.
• W2022697357 cites W2122716433 @default.
• W2022697357 cites W2125828034 @default.
• W2022697357 cites W2127361574 @default.
• W2022697357 cites W2127823826 @default.
• W2022697357 cites W2131917260 @default.
• W2022697357 cites W2136923459 @default.
• W2022697357 cites W2138336750 @default.
• W2022697357 cites W2142655750 @default.
• W2022697357 cites W2144714650 @default.
• W2022697357 cites W2145142496 @default.
• W2022697357 cites W2146558971 @default.
• W2022697357 cites W2146883699 @default.
• W2022697357 cites W2157000129 @default.
• W2022697357 cites W2157983067 @default.
• W2022697357 cites W2161446823 @default.
• W2022697357 cites W4234756901 @default.
• W2022697357 cites W4240237951 @default.
• W2022697357 cites W4292166591 @default.
• W2022697357 doi "https://doi.org/10.1016/j.freeradbiomed.2008.10.026" @default.
• W2022697357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2828157" @default.
• W2022697357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19027064" @default.
• W2022697357 hasPublicationYear "2009" @default.
• W2022697357 type Work @default.
• W2022697357 sameAs 2022697357 @default.
• W2022697357 citedByCount "114" @default.
• W2022697357 countsByYear W20226973572012 @default.
• W2022697357 countsByYear W20226973572013 @default.
• W2022697357 countsByYear W20226973572014 @default.
• W2022697357 countsByYear W20226973572015 @default.
• W2022697357 countsByYear W20226973572016 @default.
• W2022697357 countsByYear W20226973572017 @default.
• W2022697357 countsByYear W20226973572018 @default.
• W2022697357 countsByYear W20226973572019 @default.
• W2022697357 countsByYear W20226973572020 @default.
• W2022697357 countsByYear W20226973572021 @default.
• W2022697357 countsByYear W20226973572022 @default.
• W2022697357 countsByYear W20226973572023 @default.
• W2022697357 crossrefType "journal-article" @default.
• W2022697357 hasAuthorship W2022697357A5025811477 @default.
• W2022697357 hasAuthorship W2022697357A5044321008 @default.
• W2022697357 hasAuthorship W2022697357A5045890628 @default.
• W2022697357 hasAuthorship W2022697357A5048650670 @default.
• W2022697357 hasAuthorship W2022697357A5054202326 @default.
• W2022697357 hasAuthorship W2022697357A5067454062 @default.
• W2022697357 hasAuthorship W2022697357A5067971569 @default.
• W2022697357 hasAuthorship W2022697357A5072089972 @default.
• W2022697357 hasAuthorship W2022697357A5081578838 @default.
• W2022697357 hasAuthorship W2022697357A5082803074 @default.

• next